• Mashup Score: 8

    In the mating response in yeast, pheromone stimulation initiates a MAPK signaling cascade that alleviates the repression of the transcription factor Ste12 by Dig1 and Dig2, resulting in transcriptional changes, and that activates a factor called Far1, which promotes Ste12 degradation. Pomeroy et al. found that pheromone-induced transcriptional regulation showed persistence after pheromone removal…

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    • Using a predictive model of gene expression, researchers establish how distinct elements of signaling pathways coordinate responses to pheromones in mating #yeast cells. @SciSignal #SystemsBiology ($) https://t.co/kFgZ2JARaC https://t.co/rsCECTnlMs

  • Mashup Score: 37

    In the mating response in yeast, pheromone stimulation initiates a MAPK signaling cascade that alleviates the repression of the transcription factor Ste12 by Dig1 and Dig2, resulting in transcriptional changes, and that activates a factor called Far1, which promotes Ste12 degradation. Pomeroy et al. found that pheromone-induced transcriptional regulation showed persistence after pheromone removal…

    Tweet Tweets with this article
    • Using a predictive model of gene expression, researchers establish how distinct elements of signaling pathways coordinate responses to pheromones in mating #yeast cells. @SciSignal #SystemsBiology ($) https://t.co/kFgZ2JARaC https://t.co/DZZrTrniOC

  • Mashup Score: 7

    Omics techniques generate large, multidimensional data that are amenable to analysis by new informatics approaches alongside conventional statistical methods. Systems theories, including network analysis and machine learning, are well placed for analysing these data but must be applied with an understanding of the relevant biological and computational theories. Through applying these techniques…

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    • New #Review! Systems biology in cardiovascular disease: a multiomics approach. Mayr and colleagues describe techniques and sources of #omics data and highlight exemplars of #systemsbiology multiomics approaches in #cardiovascular research https://t.co/IezhZCIPwD @Vascular_Prot https://t.co/4y1sStK7al

  • Mashup Score: 6

    Volume 20 Issue 4, April 2020

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    • Our April issue, out NOW! Featuring articles on tumour cell-autonomous signalling after #radiotherapy; #CD8 #Tcell states in human cancer; cancer #systemsbiology & #TumourHeterogeneity and evolutionary trade-offs of #cancer. Have a look: https://t.co/gCTpj2jU4s @NatResCancer https://t.co/WmoqYAHIE8

  • Mashup Score: 27

    COVID-19 represents a global crisis, yet major knowledge gaps remain about human immunity to SARS-CoV-2. We analyzed immune responses in 76 COVID-19 patients and 69 healthy individuals from Hong Kong and Atlanta. In PBMCs of COVID-19 patients, there was reduced expression of HLA-DR and pro-inflammatory cytokines by myeloid cells, and impaired mTOR-signaling and IFN-α production by plasmacytoid…

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    • .@Stanford researchers who used a #SystemsBiology approach to study host immune responses in mild and severe #COVID19 identified immune proteins that correlate with disease severity and could inform therapies against #COVID19. https://t.co/ocAEzbux9k

  • Mashup Score: 1

    COVID-19 represents a global crisis, yet major knowledge gaps remain about human immunity to SARS-CoV-2. We analyzed immune responses in 76 COVID-19 patients and 69 healthy individuals from Hong Kong and Atlanta. In PBMCs of COVID-19 patients, there was reduced expression of HLA-DR and pro-inflammatory cytokines by myeloid cells, and impaired mTOR-signaling and IFN-α production by plasmacytoid…

    Tweet Tweets with this article
    • .@Stanford researchers who used a #SystemsBiology approach to study host immune responses in mild and severe #COVID19 identified immune proteins that correlate with disease severity and could inform therapies against #COVID19. https://t.co/ocAEzbM80S https://t.co/4rFmmf8yxF

  • Mashup Score: 2

    This Analysis surveys several major cancer systems biology approaches with attention to how well their resulting network maps cover, and enhance, our knowledge of cancer pathways.

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    • A census of pathway maps in cancer #systemsbiology https://t.co/bmTsjKTRX1 @NatureRevCancer #Cancer #NetworkMedicine #NetworkBiology #Biomarker The increasing molecularization of cancer clinical translation: https://t.co/L6uB2Vh7PW

  • Mashup Score: 1

    The kidney is a complex organ responsible for maintaining multiple aspects of homeostasis in the human body. The combination of distinct, yet interrelated, molecular functions across different cell types make the delineation of factors associated with loss or decline in kidney function challenging. Consequently, there has been a paucity of new diagnostic markers and treatment options becoming…

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    • A #SystemsBiology approach to understanding the kidney leverages recent advances in computational technology and methods to integrate diverse sets of data https://t.co/ML3dAoIyYr https://t.co/fRvPTh9kLZ