unique individual cases cannot be underestimated. These individual case stories that tell compelling presentations and outcomes can be helpful.The opportunity to oversee these submissions to the research topic within gastrointestinal cancers was of interest to me since it brings to focus a diverse array of case reports. Often, these are what the National Cancer Institute (NCI) calls the “exceptional responders”. 1 It brings to light these patients with unique cancers and exceptional clinical outcomes. Figure 1 illustrates how each patient from diverse backgrounds and different cancers with their treatment journey typifies an individual story. And needs to be viewed as such.If we look at the spectrum of these individual reports, some are deep, brisk, durable, and sometimes curative outcomes to different kinds of novel therapies. Some are new or off-label usage of drugs for actionable markers in histologies or cancer types or settings for which they still are not approved by regulatory a