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Mashup Score: 9Development of intravenously administered synthetic RNA virus immunotherapy for the treatment of cancer - Nature Communications - 3 year(s) ago
The development of neutralizing antibodies can limit the therapeutic effectiveness of systemically administered oncolytic viruses (OV). Here, to enable repeated intravenous administration, the authors report the development of synthetic RNA viruses formulated within lipid nanoparticles, showing anti-tumor efficacy even in the presence of OV neutralizing antibodies.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0
Discover the current landscape of oncolytic virus development in the latest review article from Future Oncology.
Source: Oncology CentralCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Oncolytic viruses: challenges and considerations in an evolving clinical landscape | Future Oncology - 3 year(s) ago
Despite advances in treatment, cancer remains a leading cause of death worldwide. Although treatment strategies are continually progressing, cancers have evolved many mechanisms for evading therapies and the host immune system. Oncolytic viruses (OVs) could provide a much-needed option for cancers that are resistant to existing treatments. OVs can be engineered to specifically target and kill…
Source: Future OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 4Optimizing Oncolytic Viral Design to Enhance Antitumor Efficacy: Progress and Challenges - PubMed - 5 year(s) ago
The field of oncolytic virotherapy has seen remarkable advancements in last two decades, leading to approval of the first oncolytic immuno-virotherapy, Talimogene Laherparepvec, for the treatment of melanoma. A plethora of preclinical and clinical studies have demonstrated excellent safety profiles …
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet
Development of synthetic RNA viruses for cancer therapy. https://t.co/FJcgugfGrr @OncorusInc #oncolyticviruses #immunotherapy #cancer #SyntheticRNAvirus #CancerResearch @natrescancer https://t.co/ElNGMUmIoc