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Mashup Score: 2How genome doubling helps cancer develop - 1 year(s) ago
Researchers at EPFL and UNIL have uncovered a new way in which cancer can develop: whole genome doubling (WGD) changes the way DNA is organized in the 3D space, leading to the activation of oncogenes that drive cancer growth.
Source: EurekAlert!Categories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0
POH1/Rpn11/PSMD14 is a highly conserved protein in eukaryotes from unicellular organisms to human and has a crucial role in cellular homoeostasis. It is a subunit of the regulatory particle of the proteasome, where it acts as an intrinsic deubiquitinase removing polyubiquitin chains from substrate proteins. This function is not only coupled to the translocation of substrates into the core of the…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
POH1/Rpn11/PSMD14: a journey from basic research in fission yeast to a prognostic marker and a druggable target in cancer cells Read for free: https://t.co/jtaG70f65G #Drugdevelopment #Molecularmedicine #Oncogenes https://t.co/ARZMiuvdN2
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Mashup Score: 0HIF-1α stimulates the progression of oesophageal squamous cell carcinoma by activating the Wnt/β-catenin signalling pathway - 2 year(s) ago
This study aimed to clarify the significance of the crosstalk between hypoxia-inducible factor-1α (HIF-1α) and the Wnt/β-catenin pathway in oesophageal squamous cell carcinoma (ESCC). The oncogenic role of HIF-1α in ESCC was investigated using in vitro and in vivo assays. The clinicopathological significance of HIF-1α, β-catenin and TCF4/TCF7L2 in ESCC were evaluated using quantitative real-time…
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
HIF-1α stimulates the progression of oesophageal squamous cell carcinoma by activating the Wnt/β-catenin signalling pathway Read for free using #SharedIt: https://t.co/sNvsMANiAZ #Cancermicroenvironment #Oncogenes https://t.co/Libzdf2Ja5
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Mashup Score: 1
Patients with metastatic bladder cancer have very poor prognosis and predictive biomarkers are urgently needed for early clinical detection and intervention. In this study, we evaluate the effect and mechanism of Suprabasin (SBSN) on bladder cancer metastasis. A tissue array was used to detect SBSN expression by immunohistochemistry. A tumour-bearing mouse model was used for metastasis evaluation…
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3 signalling Read for free using #SharedIt: https://t.co/XPXGjrxLUo #Bladdercancer #Oncogenes https://t.co/ct0v4HHVy6
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Mashup Score: 0Viral and cellular oncogenes promote immune evasion - Oncogene - 2 year(s) ago
Thirteen percent of cancers worldwide are associated with viral infections. While many human oncogenic viruses are widely endemic, very few infected individuals develop cancer. This raises the question why oncogenic viruses encode viral oncogenes if they can replicate and spread between human hosts without causing cancer. Interestingly, viral infection triggers innate immune signaling pathways…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In our latest issue @philiplabvandy & co-workers review the ways viral and cellular #oncogenes play a dual role in #carcinogenesis to circumvent cell cycle checkpoints and evade immune responses 🔬 https://t.co/azsfqiI27z
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Mashup Score: 15
Welcome! You are invited to join a webinar: Frontiers in Cardiovascular Science Seminar – Chinmay M. Trivedi, MD, PhD. After registering, you will receive a confirmation email about joining the webinar.
Source: Zoom Video CommunicationsCategories: Cardiologists, Latest HeadlinesTweet-
Please join @StanfordCVI seminar on Tue 9/14, 1-2pm PST. Speaker is Dr. Chinmay Trivedi @UMass_Medicine on #oncogenes in #cardiac and #vascular diseases. Zoom: https://t.co/4PrlOWObpV PW: 092021 @StanfordDeptMed @StanCVFellows @BCVSearlyCareer @Stanford_ChEMH @vascularbiology https://t.co/guoFQGvuF9
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Mashup Score: 1Enabling oncogenes - 3 year(s) ago
Melanoma can arise only from cells with a permissive chromatin landscape
Source: ScienceCategories: Healthcare Professionals, Latest HeadlinesTweet-
Enabling #oncogenes: https://t.co/FKxgjNjkSt Developmental #chromatin programs determine oncogenic competence in #melanoma: https://t.co/qLOztrRSzo "These data indicate that developmental chromatin programs are a determinant of how cells respond to DNA #mutations." https://t.co/NBLacZARAU
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Mashup Score: 0
Genome-wide association studies (GWASes) have identified many noncoding germline single-nucleotide polymorphisms (SNPs) that are associated with an increased risk of developing cancer. However, how these SNPs affect cancer risk is still largely unknown. We used a systems biology approach to analyse the regulatory role of cancer-risk SNPs in thirteen tissues. By using data from the Genotype-Tissue…
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Our 2nd most talked about paper is "Nongenic cancer-risk SNPs affect #oncogenes, tumour-suppressor genes, and immune function" by @johnquackenbush @Maud089 @mkuijjer @HarvardBiostats and colleagues Read the research here: https://t.co/4IhubF5mKX https://t.co/7dYshJQmSb
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Mashup Score: 1Scientists ID gene responsible for deadly glioblastoma - 4 year(s) ago
The discovery of the oncogene responsible for glioblastoma could be the brain cancer’s Achilles’ heel, one researcher says.
Source: ScienceDailyCategories: Healthcare Professionals, Latest HeadlinesTweet-
Scientists ID gene responsible for deadly #glioblastoma: https://t.co/hVK6xBmFCb #glioma #Actin #cytoskeleton #AVIL #FOXM1 #LIN28B @NatureComms : https://t.co/2YQIyI2lj2 "In this day and age, many people thought that all the significant #oncogenes have been discovered, .." https://t.co/zDM6jKKvkx
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Mashup Score: 0Identifying novel oncogenic RET mutations and characterising their sensitivity to RET-specific inhibitors - 4 year(s) ago
Background Rearranged during transfection ( RET ) is a well-known proto-oncogene. Multiple RET oncogenic alterations have been identified, including fusions and mutations. Although RET fusions have been reported in multiple cancers, RET mutations were mainly found in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma. RET mutations in other cancers were underinvestigated and…
Source: Journal of Medical GeneticsCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Identifying novel oncogenic RET mutations and characterising their sensitivity to RET-specific inhibitors https://t.co/37NhSaJf5V #retmutations #oncogenes #cancergenetics #cancerresearch #medicalresearch
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Researchers have uncovered a new way in which #cancer can develop: whole genome doubling (WGD) changes the way #DNA is organized in the #3D space, leading to the activation of #oncogenes that drive cancer growth @EPFL_en #cancerresearch https://t.co/Q98KWuBH0B