-
Mashup Score: 5Study clarifies mystery of crocodilian hemoglobin - 1 year(s) ago
The crocodilian edition of hemoglobins — the scuba tanks of the blood — work so well that crocs can go hours without air. The hyper-efficiency of that adaptation has led some biologists to wonder why, of all the jawed vertebrates, crocodilians were the lone group to hit on such an optimal solution to making the most of a breath. After resurrecting the hemoglobin of ancient crocodilian ancestors,…
Source: EurekAlert!Categories: General Medicine News, Latest HeadlinesTweet
-
Mashup Score: 9Control-independent mosaic single nucleotide variant detection with DeepMosaic - Nature Biotechnology - 1 year(s) ago
A deep learning model detects low frequency mosaic variants with improved accuracy.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
New #computer program 'learns' to identify mosaic #mutations that cause disease @ucsandiego @NatureBiotech https://t.co/jF199GWJ8w https://t.co/yyv8yy9gmk
-
-
Mashup Score: 1Study Opens Door to Cancer Research in the ‘Dark Matter’ of the Genome | Dana-Farber Cancer Institute - 1 year(s) ago
Published: May 31, 2022Key Takeaways: Mutations in non-protein-coding regions of the genome – the “dark matter” of the genome – have been difficult to link to cancer. A new study provides a blueprint for future research into the role of mutations across the genome and their possible link to cancer. When a dam collapses because … Read more
Source: Dana-Farber Cancer InstituteCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
A new study provides a blueprint for future research into the role of #mutations across the #genome and their possible link to #cancer. https://t.co/XznLvsBnl6
-
-
Mashup Score: 0Pathogenic Germline Variants Seen in Older Patients With MDS More Frequently Than Expected | ASH Clinical News | American Society of Hematology - 2 year(s) ago
Skip Nav Destination October 27, 2022 Patients of all ages with myelodysplastic syndromes (MDS) who underwent related allogeneic hematopoietic cell transplantation (alloHCT) have a greater frequency of pathogenic germline mutations…
Source: ashpublications.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
Patients of all ages with #MDS who had undergone related alloHCT were found to have a greater frequency of pathogenic #germline #mutations than was previously known https://t.co/cB3xx1MMV2
-
-
Mashup Score: 4
Abstract. Purpose: Large-scale sequencing efforts have established that cancer-associated genetic alterations are highly diverse, posing a challenge to the identification of variants that regulate complex phenotypes like radiation sensitivity. The impact of the vast majority of rare or common genetic variants on the sensitivity of cancers to radiotherapy remains largely unknown. Experimental…
Categories: General Medicine News, Latest HeadlinesTweet-
Exploring how gene #mutations in tumors impact radiation sensitivity @northwesternu https://t.co/CRUnp7Bk8z https://t.co/DLi9L88joB
-
-
Mashup Score: 0Wolters Kluwer Health - 2 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
All patients diagnosed with #lungcancer should be considered for #germlinetesting, according to a new #study on the prevalence and spectrum of pathogenic germline variants (PGVs) in patients diagnosed with lung cancer: https://t.co/f6iSCwhsCE #mutations #OncNews https://t.co/EFLdYJb4t8
-
-
Mashup Score: 16The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness - Scientific Reports - 2 year(s) ago
During COVID-19 pandemic, mutations of SARS-CoV-2 produce new strains that can be more infectious or evade vaccines. Viral RNA mutations can arise from misincorporation by RNA-polymerases and modification by host factors. Analysis of SARS-CoV-2 sequence from patients showed a strong bias toward C-to-U mutation, suggesting a potential mutational role by host APOBEC cytosine deaminases that possess…
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
COVID-19 #mutations accelerated by virus-fighting enzyme in #humancells, according to new research @USC @SciReports https://t.co/Z2bbTGIc5H https://t.co/Ah0O9j7TgW
-
-
Mashup Score: 0Wolters Kluwer Health - 2 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
It was previously thought that p53 and PI3K/Akt were separate and regulated by different #cellularsignals. Recently, however, a team at @UWMadison found a direct link between the two #mutations that could lead to more effective #treatments: https://t.co/RBgYoktvVO https://t.co/sElv3XQuXN
-
-
Mashup Score: 0Advancing precision medicines for ocular disorders: Diagnostic genomics to tailored therapies - 2 year(s) ago
Successful sequencing of the human genome and evolving functional knowledge of gene products has taken genomic medicine to the forefront, soon combining broadly with traditional diagnostics, therapeutics, and prognostics in patients. Recent years have witnessed an extraordinary leap in our understanding of ocular diseases and their respective genetic underpinnings. As we are entering the age of…
Source: FrontiersCategories: Hem/Oncs, Latest HeadlinesTweet-
Gene therapy strategies for inherited diseases of the eye. This schematic represents the potential therapeutic approaches that #gene #therapy offers various #retinal diseases. Read the review: #Mutations #Retina #NEI @NIH @genome_gov #PrecisionMedicine https://t.co/aex41mDZgs https://t.co/UX9j7z8aHY
-
-
Mashup Score: 14Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity - Nature Aging - 2 year(s) ago
Somatic mutations accumulate with age; however, the role they have in cardiac aging is unclear. Here Choudhury et al. describe the somatic mutation landscape of human heart muscle cells by single-cell whole-genome sequencing and report mutational signatures indicative of increased oxidative DNA damage and failed repair.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
The aging #heart accumulates #mutations—while losing the ability to repair them @bostonchildrens @NatureAging https://t.co/aGUiHoag67 https://t.co/Qrv8GK16fK
-
Experiments on ancient #proteins find #mutations more numerous, nuanced than once thought @UNLincoln #evolution #hemoglobin #evolutionarygenetics https://t.co/WU4orNjhER