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Mashup Score: 26Single-cell profiling reveals kidney CD163+ dendritic cell participation in human lupus nephritis - 3 month(s) ago
Objectives The current work aimed to provide a comprehensive single-cell landscape of lupus nephritis (LN) kidneys, including immune and non-immune cells, identify disease-associated cell populations and unravel their participation within the kidney microenvironment. Methods Single-cell RNA and T cell receptor sequencing were performed on renal biopsy tissues from 40 patients with LN and 6 healthy donors as controls. Matched peripheral blood samples from seven LN patients were also sequenced. Multiplex immunohistochemical analysis was performed on an independent cohort of 60 patients and validated using flow cytometric characterisation of human kidney tissues and in vitro assays. Results We uncovered a notable enrichment of CD163+ dendritic cells (DC3s) in LN kidneys, which exhibited a positive correlation with the severity of LN. In contrast to their counterparts in blood, DC3s in LN kidney displayed activated and highly proinflammatory phenotype. DC3s showed strong interactions with
Source: ard.bmj.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 6Proximity extension assay proteomics and renal single cell transcriptomics uncover novel urinary biomarkers for active lupus nephritis - 3 month(s) ago
To identify urinary biomarkers that can distinguish active renal involvement in Lupus Nephritis (LN), a severe manifestation of systemic lupus erythem…
Source: www.sciencedirect.comCategories: General Medicine News, General HCPsTweet-
New biomarkers for active #lupusNephritis discovered https://t.co/IYk1JTazXS https://t.co/gkRH3o7h7w
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Mashup Score: 77Pathogenic cellular and molecular mediators in lupus nephritis - 3 month(s) ago
Nature Reviews Nephrology – This Review examines the contribution of innate and adaptive immune cells to the pathogenesis of lupus nephritis, including new insights into the molecular mechanisms…
Source: www.nature.comCategories: General Medicine News, CardiologistsTweet-
RT @NatRevNeph: Overview of pathogenic mechanisms in #LupusNephritis and potential therapeutic targets. https://t.co/vz3kru7T3c https://t.…
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Mashup Score: 293Pathogenic cellular and molecular mediators in lupus nephritis - Nature Reviews Nephrology - 3 month(s) ago
This Review examines the contribution of innate and adaptive immune cells to the pathogenesis of lupus nephritis, including new insights into the molecular mechanisms that drive this disease, such as recognition of endogenous chromatin by endosomal and cytosolic nucleic acid sensors.
Source: www.nature.comCategories: General Medicine News, NephrologyTweet-
Overview of pathogenic mechanisms in #LupusNephritis and potential therapeutic targets. https://t.co/vz3kru7T3c https://t.co/lKGs9j6Mhk
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Mashup Score: 1Managing Lupus Nephritis: Importance of Immunosuppression and Mitigation of Tissue Fibrosis | Lupus Science and Medicine Podcast - 6 month(s) ago
Dr. Anna Wolska from the Lupus Foundation of America interviews Drs. Ana Malvar and Brad Rovin. They discuss using repeat tissue biopsies to understand progression of lupus nephritis over time. They offer conjecture that both immunosuppression as well as mitigation of tissue fibrosis, resulting from inflammatory resolution, are needed in order to preserve kidney function and prevent progression to kidney failure. Read the related article – http://dx.doi.org/10.1136/lupus-2023-000932
Source: lupusbmj.podbean.comCategories: Latest Headlines, RheumatologyTweet-
New Podcast on LSM: #Lupus #LupusNephritis #Fibrosis #SLE #Autoimmunity @LupusOrg https://t.co/mNf04jGGfR
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Mashup Score: 0Managing Lupus Nephritis: Importance of Immunosuppression and Mitigation of Tissue Fibrosis | Lupus Science and Medicine Podcast - 7 month(s) ago
Dr. Anna Wolska from the Lupus Foundation of America interviews Drs. Ana Malvar and Brad Rovin. They discuss using repeat tissue biopsies to understand progression of lupus nephritis over time. They offer conjecture that both immunosuppression as well as mitigation of tissue fibrosis, resulting from inflammatory resolution, are needed in order to preserve kidney function and prevent progression to kidney failure. Read the related article – http://dx.doi.org/10.1136/lupus-2023-000932
Source: lupusbmj.podbean.comCategories: Latest Headlines, RheumatologyTweet-
New Podcast on LSM: #Lupus #LupusNephritis #Fibrosis #SLE #Autoimmunity @LupusOrg https://t.co/mNf04jGGfR
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Mashup Score: 1Managing Lupus Nephritis: Importance of Immunosuppression and Mitigation of Tissue Fibrosis | Lupus Science and Medicine Podcast - 7 month(s) ago
Dr. Anna Wolska from the Lupus Foundation of America interviews Drs. Ana Malvar and Brad Rovin. They discuss using repeat tissue biopsies to understand progression of lupus nephritis over time. They offer conjecture that both immunosuppression as well as mitigation of tissue fibrosis, resulting from inflammatory resolution, are needed in order to preserve kidney function and prevent progression to kidney failure. Read the related article – http://dx.doi.org/10.1136/lupus-2023-000932
Source: lupusbmj.podbean.comCategories: Latest Headlines, RheumatologyTweet-
New Podcast on LSM: #Lupus #LupusNephritis #Fibrosis #SLE #Autoimmunity @LupusOrg https://t.co/mNf04jGGfR
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Mashup Score: 0ACR Journals on Air Podcast - 7 month(s) ago
Listen to ACR Journals on Air, the ACR’s newest podcast series featuring interviews, commentary, and analysis on research from our three peer-reviewed journals: Arthritis & Rheumatology, Arthritis Care & Research, and ACR Open Rheumatology.
Source: rheumatology.orgCategories: Latest Headlines, RheumatologyTweet-
What is the pLCI & how did podcast guest @JoyceChangMD encourage its adoption in the #pedsrheum community? Plus, how she developed a population management strategy for young people with #lupusnephritis. Listen → https://t.co/xX94rJ9yJy @ACR_Journals https://t.co/zwINSlguJ4
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Mashup Score: 0
A study suggests that strains of ruminococcus (blautia) gnavus (RG) seen in the gut microbiome of patients in active lupus nephritis might be drivers of disease flares and highlight the possible pathogenic qualities of specific strains.
Source: AJMCCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A study suggests that strains of ruminococcus (blautia) gnavus seen in the gut microbiome of patients in active #LupusNephritis might be drivers of disease flares and highlight the possible pathogenic qualities of specific strains. https://t.co/uJquaIbVBd
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Mashup Score: 0Lupus Clinical Practice Guideline - 10 month(s) ago
Read American College of Rheumatology recommendations for the treatment and management of lupus.
Source: rheumatology.orgCategories: Latest Headlines, RheumatologyTweet-
Final Call for Letters of Interest—Those who wish to partner with the ACR on a clinical practice guideline project that was broadened from #lupusnephritis to all of #lupus are encouraged to submit letters of interest by Wednesday, July 5. Details → https://t.co/CQjnXHo3Uz https://t.co/is9V7k1Q3p
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Single cell profiling revealed new clues on #lupus #nephritis: ▶️ novel subset of dendritic cells uncovered (DC3) ▶️ activated and proinflammatory phenotype ▶️ linked to T cell polarisation ▶️ potential biomarker of treatment response 🔗 https://t.co/H3TeC6oa4M https://t.co/b9CAP5Pi7x