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    is article was to critically review the evidence from clinical development studies to date on the efficacy and safety of new RNA-based therapeutics for targeted lowering of Lp(a). PubMed/MEDLINE, Scopus, Web of Science, and ClinicalTrials.gov were searched without any language or date restriction up to November 5, 2022, and a total of 12 publications and 22 trial records were included. Several drugs were found that are currently in various stages of clinical development, such as the antisense oligonucleotide pelacarsen and the small interfering RNA molecule olpasiran and drugs coded as SLN360 and LY3819469. Among them, pelacarsen has progressed the most, currently reaching phase 3. All these drugs have so far shown satisfactory pharmacokinetic properties, consistently high and stable, dose-dependent efficacy in lowering Lp(a) even by more than 90%, with an acceptable safety profile in subjects with highly elevated Lp(a). In addition, reports of early clinical trials with pelacarsen imp

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    La Lp(a)Publié le 20 juin 2023- Durée : 00:06:24Dr Pierre Sabouret, Cardiologue à Paris Attention, pour des raisons réglementaires ce site est réservé aux professionnels de santé. pour voir la suite, inscrivez-vous gratuitement. Si vous êtes déjà inscrit,connectez vous : Se connecter Si vous n’êtes pas encore inscrit au site,inscrivez-vous gratuitement : Je m’inscris

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    • All that you want to know about Lp(a) without asking at #AXISTV https://t.co/dGdqKu0RPt #LLT #lipids