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    Background and Objectives: The roles of Lewy body (LB) and separately of cerebrovascular disease (CVD) pathologies in the severity of parkinsonian signs are well recognized in old age. We investigated whether the two pathologies act synergistically to further potentiate the severity of parkinsonism beyond their separate effects. Methods: We employed postmortem data of decedents from 3…

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    • Via @GreenJournal: Atherosclerosis and macroscopic infarcts may interact with #LewyBody pathology, increasing the severity of #parkinsonism beyond their additive effects in older patients: https://t.co/XJJ4GntmN6 #neurotwitter #dementia @AANMember https://t.co/URLFII5tg4

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    Newcastle University, Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, United Kingdom.  Telephone: (0191) 208 1310 © 2017 Newcastle University

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    • #Lewybody #dementia is a multi-system disease that includes #Depression #Psychosis and physical symptoms similar to #Parkinsonsdisease. Don't miss the signs, access @NIHRcommunity funded DIAMOND-Lewy via @UniofNewcastle here https://t.co/ZR5OFNyyPD #BGSconf https://t.co/6I05bAAVPc

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    Background and Objectives. Patients with Lewy body disease (LBD) often show a co-occurring Alzheimer’s disease (AD) pathology. Cerebrospinal fluid (CSF) biomarkers allow the detection in vivo of AD-related pathological hallmarks included in the AT(N) classification system. Here, we aimed to investigate whether CSF biomarkers of synaptic and neuro-axonal damage are correlated with the presence of…

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    • Via @GreenJournal: Patients with #LewyBody disease/A+T+ and those with #Alzheimers had significantly higher cerebrospinal fluid levels of synaptic and neuro-axonal biomarkers than patients with Lewy body disease/A-T- and controls: https://t.co/i3fiisQI8O #neurotwitter @AANMember https://t.co/5gJNfDMUTc

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    I am writing to share a story with you, specifically for you. My hope is that it will help you understand your patients along with their spouses and caregivers a little more. And as for the research you do, perhaps this will add a few more faces behind the why you do what you do. I am sure there are already so many.

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    • The terrorist inside my husband's brain Susan Schneider Williams, remembering Robin Williams in @GreenJournal https://t.co/OoqMvZYJ6a #lewybody

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    Background and Objectives 123I-meta-iodobenzyl-guanidine (123I-MIBG) myocardial scintigraphy is used as a diagnostic imaging test to differentiate Lewy body diseases (LBDs), including Parkinson disease and dementia with Lewy bodies, from other similar diseases. However, this imaging test lacks validation of its diagnostic accuracy against the gold standard. Our aim was to validate the diagnostic…

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    • This study provides Class II evidence that 123I-MIBG myocardial scintigraphy accurately identifies patients with #LewyBody disease. Read the open access article now: https://t.co/EitaWlPMu3 #NeuroTwitter #Neurology https://t.co/LFxOFgBGOJ

  • Mashup Score: 3

    Background and Objectives: 123I-meta-iodobenzyl-guanidine (123I-MIBG) myocardial scintigraphy is employed as a diagnostic imaging test to differentiate Lewy body diseases (LBDs), including Parkinson’s disease and dementia with Lewy bodies, from other similar diseases. However, its diagnostic accuracy lacks validation compared with that of the gold standard. We aimed to validate the diagnostic…

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    • This clinicopathological validation study revealed that 123I-meta-iodobenzyl-guanidine myocardial scintigraphy could robustly differentiate #LewyBody diseases from similar diseases. Learn more: https://t.co/814WRknFTM #NeuroTwitter https://t.co/D5Iglx07Wi