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Mashup Score: 0
Pantothenate kinase–associated neurodegeneration (PKAN) is an incurable rare genetic disorder of children and young adults caused by mutations in the PANK2 gene, which encodes an enzyme critical for the biosynthesis of coenzyme A. Although PKAN affects only a small number of patients, it shares several hallmarks of more common neurodegenerative diseases of older adults such as Alzheimer’s disease…
Source: Journal of Biological ChemistryCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 0Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases - 3 year(s) ago
Aptamers are oligonucleotides selected from large pools of random sequences based on their affinity for bioactive molecules and are used in similar ways to antibodies. Aptamers provide several advantages over antibodies, including their small size, facile, large-scale chemical synthesis, high stability, and low immunogenicity. Amyloidogenic proteins, whose aggregation is relevant to…
Source: Journal of Biological ChemistryCategories: Latest Headlines, NeurologyTweet-
#JBCReviews | In view of the development of these techniques and resources, here Murakami et al. review anti-amyloid aptamers, highlighting preclinical application to #CNS therapy — @UCLAHealthNews @uclachem #neuro https://t.co/xBFdojmqZd
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Mashup Score: 0The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain - 3 year(s) ago
The complement cascade is a key component of the innate immune system that is rapidly recruited through a cascade of enzymatic reactions to enable the recognition and clearance of pathogens and promote tissue repair. Despite its well-understood role in immunology, recent studies have highlighted new and unexpected roles of the complement cascade in neuroimmune interaction and in the regulation of…
Source: Journal of Biological ChemistryCategories: Latest Headlines, NeurologyTweet-
Here, Warwick et al. review mechanisms of neuronal and complement signaling crosstalk which regulate synaptic plasticity and neuronal excitability ― #JBCReviews @IowaMed @uiowa @uihealthcare #neuro #neurodegeneration #neuroimmunology https://t.co/P19Osthphe
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Mashup Score: 1The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain - 3 year(s) ago
The complement cascade is a key component of the innate immune system that is rapidly recruited through a cascade of enzymatic reactions to enable the recognition and clearance of pathogens and promote tissue repair. Despite its well-understood role in immunology, recent studies have highlighted new and unexpected roles of the complement cascade in neuroimmune interaction and in the regulation of…
Source: Journal of Biological ChemistryCategories: Allergy-Immunology, Latest HeadlinesTweet-
Here, Warwick et al. review mechanisms of neuronal and complement signaling crosstalk which regulate synaptic plasticity and neuronal excitability ― #JBCReviews @IowaMed @uiowa @uihealthcare #neuro #neurodegeneration #neuroimmunology https://t.co/F9idvNyuxR
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#JBCReviews | Redesigning therapies for pantothenate kinase-associated #neurodegeneration | Munshi et al. summarize their knowledge of #PKAN and demonstrate how it forms the backdrop to new avenues of research — @YaleMed #neuro #genetherapy https://t.co/m4NIAreRl8