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Mashup Score: 23
There is a new awareness of the widespread nature of metabolic dysfunction–associated steatotic liver disease (MASLD) and its connection to cardiovascular disease (CVD). This has catalyzed collaboration between cardiologists, hepatologists, endocrinologists, and the wider multidisciplinary team to address the need for earlier identification of those with MASLD who are at increased risk for CVD. The overlap in the pathophysiologic processes and parallel prevalence of CVD, metabolic syndrome, and MASLD highlight the multisystem consequences of poor cardiovascular–liver–metabolic health. Metabolic dysfunction and associated insulin resistance, together with the predilection for ectopic fat deposition in the liver and surrounding tissues, are associated with elevated risk of endothelial dysfunction, systemic inflammatory response, and ectopic fat deposition in the epicardium. This complex pathophysiology can accelerate atherogenic dyslipidemia, atherogenesis, diastolic dysfunction, valvula
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 23
There is a new awareness of the widespread nature of metabolic dysfunction–associated steatotic liver disease (MASLD) and its connection to cardiovascular disease (CVD). This has catalyzed collaboration between cardiologists, hepatologists, endocrinologists, and the wider multidisciplinary team to address the need for earlier identification of those with MASLD who are at increased risk for CVD. The overlap in the pathophysiologic processes and parallel prevalence of CVD, metabolic syndrome, and MASLD highlight the multisystem consequences of poor cardiovascular–liver–metabolic health. Metabolic dysfunction and associated insulin resistance, together with the predilection for ectopic fat deposition in the liver and surrounding tissues, are associated with elevated risk of endothelial dysfunction, systemic inflammatory response, and ectopic fat deposition in the epicardium. This complex pathophysiology can accelerate atherogenic dyslipidemia, atherogenesis, diastolic dysfunction, valvula
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
#InDepth Recommendations for Screening, Diagnosis and Management of Metabolic Dysfunction Associated Steatotic Liver Disease in CVD https://t.co/eB87sHFx4b https://t.co/pZOGzMzyPF
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Mashup Score: 11Aortic Stenosis and Coronary Artery Disease: Decision-Making Between Surgical and Transcatheter Management | Circulation - 24 day(s) ago
Aortic stenosis (AS) and coronary artery disease (CAD) frequently coexist and share pathophysiological mechanisms. The proportion of patients with AS and CAD requiring revascularization varies widely because of uncertainty about best clinical practices. Although combined surgical aortic valve replacement and coronary artery bypass grafting has been the standard of care, management options in patients with AS and CAD requiring revascularization have expanded with the advent of transcatheter aortic valve replacement (TAVR). Potential alternative treatment pathways include revascularization before TAVR, concomitant TAVR and percutaneous coronary intervention, percutaneous coronary intervention after TAVR and deferred percutaneous coronary intervention or hybrid procedures. Selection depends on underlying disease severity, antithrombotic treatment strategies, clinical presentation, and symptom evolution after TAVR. In patients undergoing surgical aortic valve replacement, the addition of c
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
An #inDepth review of the evidence supporting treatment decisions in patients with aortic stenosis and coronary artery disease @DaijiroTomii @ThomPilgrim https://t.co/zcRFkIpegc https://t.co/ZLuoHJwT3A
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Mashup Score: 8
Guidelines help to facilitate treatment decisions based on available evidence, and also to provide recommendations in areas of uncertainty. In this paper, we compare the recommendations for stroke workup and secondary prevention of ischemic stroke and transient ischemic attack of the American Heart Association (AHA)/American Stroke Association (ASA) with the European Stroke Organization (ESO) guidelines. The primary aim of this paper is to offer clinicians guidance by identifying areas where there is consensus and where consensus is lacking, in the absence or presence of high-level evidence. We compared AHA/ASA with the ESO guideline recommendations for 7 different topics related to diagnostic stroke workup and secondary prevention. We categorized the recommendations based on class and level of evidence to determine whether there were relevant differences in the ratings of evidence that the guidelines used for its recommendations. Finally, we summarized major topics of agreement and di
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
#InDepth - Comparison of American and European guidelines for diagnostic workup and secondary prevention of ischemic stroke. https://t.co/pkcQ0C7qRS https://t.co/I07nkRFvHS
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Mashup Score: 8Omega-3 Fatty Acids and Arrhythmias | Circulation - 5 month(s) ago
The pro- and antiarrhythmic effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been extensively studied in preclinical and human trials. Despite early evidence of an antiarrhythmic role of n-3 PUFA in the prevention of sudden cardiac death and postoperative and persistent atrial fibrillation (AF), subsequent well-designed randomized trials have largely not shown an antiarrhythmic benefit. Two trials that tested moderate and high-dose n-3 PUFA demonstrated a reduction in sudden cardiac death, but these findings have not been widely replicated, and the potential of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to reduce arrhythmic death in combination, or as monotherapy, remains uncertain. The accumulated clinical evidence does not support supplementation of n-3 PUFA for postoperative AF or secondary prevention of AF. Several large, contemporary, randomized controlled trials of high-dose n-3 PUFA for primary or secondary cardiovascular prevention have demonstrat
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet-
#InDepth: The pro- and anti-arrhythmic risks of omega-3 fatty acids: critical questions on formulations, dose ranges, and patient subgroups. https://t.co/AwOaNnDpjr https://t.co/xvDXJbMcYr
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Mashup Score: 5
Defining mechanisms of cardiomyocyte proliferation should guide the understanding of endogenous cardiac regeneration and could lead to novel treatments for diseases such as myocardial infarction. In
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet-
#InDepth: Metabolic reprogramming: a byproduct or a driver of cardiomyocyte proliferation? https://t.co/tiVHRPzv02
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Mashup Score: 45Evolving Contemporary Management of Atrial Fibrillation in Hypertrophic Cardiomyopathy - 1 year(s) ago
Atrial fibrillation (AF) is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM) with clinical and subclinical episodes occurring in nearly one-half of patients. AF in HCM histor
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet-
#InDepth: Evolving Contemporary Management of Atrial Fibrillation in Hypertrophic Cardiomyopathy https://t.co/WExXPXqByi https://t.co/7L2vNoj1mD
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Mashup Score: 45Evolving Contemporary Management of Atrial Fibrillation in Hypertrophic Cardiomyopathy - 1 year(s) ago
Atrial fibrillation (AF) is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM) with clinical and subclinical episodes occurring in nearly one-half of patients. AF in HCM histor
Source: www.ahajournals.orgCategories: General Medicine News, Cardiology News and JournTweet-
#InDepth: Evolving Contemporary Management of Atrial Fibrillation in Hypertrophic Cardiomyopathy https://t.co/WExXPXqByi https://t.co/7L2vNoj1mD
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Mashup Score: 8
The number of heart transplants performed annually in the United States and worldwide continues to increase, but there has been little change in graft longevity and patient survival over the past 2 d
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet-
#InDepth How can molecular diagnostics be used to improve outcomes in heart transplantation? @KiranKhush1 @laurentrubymd @Annette_HLA @PalakShahMD #AHAJournals https://t.co/kA4QREtzrR https://t.co/ofTw3ypy1s
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Mashup Score: 7GLP-1 Receptor Agonists for the Reduction of Atherosclerotic Cardiovascular Risk in Patients With Type 2 Diabetes - 2 year(s) ago
Patients with type 2 diabetes are at high risk for development of cardiovascular disease, including myocardial infarction, stroke, heart failure, and cardiovascular death. Multiple large cardiovascul
Source: CirculationCategories: Cardiology News and Journals, Latest HeadlinesTweet-
#InDepth: Learn about the cardiovascular effects of #GLP1RA in this comprehensive review: Mechanisms, trial results and practical aspects #AHAJournals https://t.co/6eeQsEA7D2 https://t.co/ZPwbI8KTfW
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#InDepth Recommendations for Screening, Diagnosis and Management of Metabolic Dysfunction Associated Steatotic Liver Disease in CVD https://t.co/eB87sHFx4b https://t.co/pZOGzMzyPF