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Mashup Score: 0A spatially resolved atlas of the human lung characterizes a gland-associated immune niche - PubMed - 2 year(s) ago
Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the human lung, but their spatial context is less well defined. To (re)define tissue architecture of lung and airways, we profiled five proximal-to-distal locations of healthy human lungs in depth using multi-om …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 1
Summary:Tumor-specific cytotoxic T cells unleashed by the blockade of immune checkpoints have to overcome a hostile tumor microenvironment (TME). They start from very small numbers of T cells with tumor antigen specificity and, despite expansion, likely remain at a numerical disadvantage to the tumor cells they target. To overcome these obstacles, we propose that T cells need to change the TME to…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Perspective: When #cancercells become the enablers of an antitumor #immune response, by Toni Ribas, @nickhaining, and Ton Schumacher. https://t.co/C85Z0yxiBY @UCLAJCCC @ArsenalBio @NKI_nl —Cancer Discovery top tweets of 2022 https://t.co/JDrqCf2ix2
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Mashup Score: 0
Inappropriate accumulation of alveolar macrophages (AMs) and subsequent excessive production of immune responses play critical roles in the pathogenesis of acute lung injury (ALI), but the core negative regulators governing innate signaling in AMs are ill defined. We have previously shown that singl …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet-
Regulation of CD18 stability by SIGIRR-modulated ubiquitination: New insights into the relationship between #innate #immune #response and #acute #lung #injury https://t.co/tlVfkFia8C https://t.co/U95U9rIPb6
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Mashup Score: 0Disseminated BCG disease with defective immune metabolism caused by protein kinase C-delta deficiency - 2 year(s) ago
Protein kinase C-delta encoded by gene PRKCD is a unique member of the protein kinase C family, expressed in all types of tissues, and functions as a key molecule in maintaining immune homeostasis.1 It plays regulatory roles in B-cell signaling, autoimmunity, growth, apoptosis, and differentiation of a variety of cell types.1-3 Since 2013, 17 patients from 10 families have been reported with…
Categories: Allergy-Immunology, Latest HeadlinesTweet-
In Current Issue! Disseminated #BCG #disease with #defective #immune #metabolism caused by #protein #kinase #C- #delta #deficiency https://t.co/B96NVIAU7P https://t.co/xRWxAH8C46
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Mashup Score: 0
IntroductionThe emergence of multiple variants of concerns (VOCs) with higher number of Spike mutations have led to enhanced immune escape by the SARS-CoV-2. With the increasing number of vaccination breakthrough (VBT) infections, it is important to understand the possible reason/s of the breakthrough infections.MethodsWe performed transcriptome sequencing of 57 VBT and unvaccinated COVID-19…
Source: FrontiersCategories: Latest Headlines, PulmonologyTweet-
Transcriptomic #study reveals lncRNA-mediated downregulation of innate #immune and #inflammatory response in the #SARS-CoV-2 #vaccination breakthrough infections https://t.co/r0MhhF8qjX https://t.co/MVLdoMEckd
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Mashup Score: 0Call for papers - The Journal of Heart and Lung Transplantation | ScienceDirect.com by Elsevier - 2 year(s) ago
Read the latest articles of The Journal of Heart and Lung Transplantation at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
Source: www.sciencedirect.comCategories: Cardiology News and Journals, Latest HeadlinesTweet-
❓ Do you conduct research on #immune sensitization or #biomarkers in #thoracic organ #transplantation? 📥Submit your work BY 31 DECEMBER to the forthcoming #JHLT special issue at https://t.co/Q5kAXT90Cv #HeartTx #LungTx #ImmuneSensitization #Immunology https://t.co/DlNyeN7yiq
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Mashup Score: 2Characterizing the role of the immune microenvironment in multiple myeloma progression at a single-cell level - 2 year(s) ago
Key Points. MM progression from precursor stages show alterations in the immune microenvironment including changes within B and T cells and macrophages.Intrinsi
Source: American Society of HematologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Characterizing the role of the #immune microenvironment in multiple #myeloma progression at a #singlecell level #mmsm https://t.co/3dG3rawo2Z https://t.co/2UJlzQ317h
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Mashup Score: 0Immune Profiling of Peripheral Blood Mononuclear Cells at Pancreas Acute Rejection Episodes in Kidney-Pancreas Transplant Recipients - 2 year(s) ago
Profiling of circulating immune cells provides valuable insight to the pathophysiology of acute rejection in organ transplantation. Herein we characterized the peripheral blood mononuclear cells in simultaneous kidney-pancreas transplant recipients. We conducted a retrospective analysis in a biopsy-matched cohort (n = 67) and compared patients with biopsy proven acute rejection (BPAR; 41%) to…
Source: FrontiersCategories: Latest Headlines, TransplantationTweet-
#Immune #cell #profiling in #SPK recipients: T cell frequencies in peripheral blood correlate with #pancreas #acute #rejection episodes, and variations prior to transplantation are associated with early #AR @CucchiariD @FritzDiekmann @PVentura_Aguiar https://t.co/3W9zM9T7H6 https://t.co/pRqkFoFkFb
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Mashup Score: 2
Background: Inflammation resolution and cardiac repair initiation after myocardial infarction (MI) require timely activation of reparative signals. Histone lactylation confers macrophage homeostatic
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Wang & colleagues demonstrate that the #epigenetic modification histone lactylation facilitates #transcription of reparative genes, thus favoring the establishment of #immune homeostasis and improving cardiac function post-#MI. Learn more at https://t.co/lfaTPrOLCu https://t.co/jfb8K2GIYi
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Mashup Score: 3Call for papers - The Journal of Heart and Lung Transplantation | ScienceDirect.com by Elsevier - 2 year(s) ago
Read the latest articles of The Journal of Heart and Lung Transplantation at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
Source: www.sciencedirect.comCategories: Cardiology News and Journals, Latest HeadlinesTweet-
❓ Do you conduct research on #immune sensitization or #biomarkers in #thoracic organ #transplantation? 📥Submit your work to the forthcoming #JHLT special issue at https://t.co/Q5kAXSRXAv #HeartTx #LungTx #ImmuneSensitization #Immunology https://t.co/COxOjcWIRh
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A spatially resolved atlas of the #human #lung characterizes a #gland- #associated #immune #niche https://t.co/8EyPa7mXS8 https://t.co/62nxD30VNf