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    COVID-19 has infected humans worldwide, causing millions of deaths or prolonged symptoms in survivors. The transient or persistent symptoms after SARS-CoV-2 infection have been defined as post-COVID-19 conditions (PCC). We conducted a study of 151 Brazilian PCC patients to analyze symptoms and immunoglobulin profiles, taking into account gender, vaccination, hospitalization and age. Fatigue and…

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    • The detection of #IgA antibodies against #SARSCoV2 may be an immunological signature to predict #LongCOVID, especially in adults and the elderly. https://t.co/5u9g3zP6vx #PASC https://t.co/CpK7TS2KtD

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    Objective We have reported previously that the IRAK4 inhibitor PF06426779 given to ubiquitin-binding-defective ABIN1[D485N] mice at 6 weeks of age prevents the major facets of lupus that develop 10 weeks later. The present study was undertaken to investigate whether PF06426779 could reverse the lupus phenotype when administered to 13-week-old ABIN1[D485N] mice that had already developed symptoms…

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    • IRAK4 inhibitor #reverses #splenomegaly, neutrophil numbers, rise in serum & glomerular #IgA levels in mice that developed #lupus & prevents further increases splenic TFH & #GerminalCentre Bcell numbers #IgG1 & #IgE concentration & kidney & liver pathology https://t.co/JvqrpYSsOg