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    Metabolic comorbidities heightened risk for adverse liver-related events among patients with chronic hepatitis B virus, with the highest risk found among patients with multiple comorbidities, according to research. “The leading causes of death among patients with chronic HBV (CHB) are hepatocellular carcinoma and liver cirrhosis-related complications,” Lesley A. Patmore, MD, from the

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    Objective Therapeutic strategies silencing and reducing the hepatitis B virus (HBV) reservoir, the covalently closed circular DNA (cccDNA), have the potential to cure chronic HBV infection. We aimed to investigate the impact of small interferring RNA (siRNA) targeting all HBV transcripts or pegylated interferon-α (peg-IFNα) on the viral regulatory HBx protein and the structural maintenance of…

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    • Excellent #GUTImage from the paper on "Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo" via https://t.co/BIg2YtZUEF @emadelomar #HBV #HepatitisBvirus #TherapeuticShutdown #LiverTwitter https://t.co/dmL2hlRrJ3