• Mashup Score: 2

    Recent findings are challenging the classical hematopoietic model in which long-term hematopoietic stem cells (LT-HSC) are the base of the hematopoietic system. Clonal dynamics analysis of the hematopoietic system indicate that LT-HSC are not the main contributors of normal hemapoiesis in physiological conditions and the hematopoietic system is mainly maintained by multipotent progenitors (MPPs,…

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    • Collaborating with @roshana_t @BigSpinLab @CarrerasIJC to show a #chromatin binding function for IΚBα that is #Polycomb repression complex 2 #PRC2 - dependent and determines activity of #hematopoietic stem cells #HSCs, @biorxivpreprint pre-print here: https://t.co/CQxOFRnHl8 https://t.co/YucfaXCbzN

  • Mashup Score: 1

    Abstract. Recently, screens for mediators of resistance to FLT3 and ABL kinase inhibitors in leukemia resulted in the discovery of LZTR1 as an adaptor of a Cullin-3 RING E3 ubiquitin ligase complex responsible for degradation of RAS GTPases. In parallel, dysregulated LZTR1 expression via aberrant splicing and mutations were identified in clonal hematopoietic conditions. Here we identify that loss…

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    • #ICYMI: Impaired Proteolysis of Non-Canonical RAS Proteins Drives Clonal #Hematopoietic Transformation, by @_SisiChen, @AbdelWahablab et al. https://t.co/wIEb5VfH8P @RSVedula @Antonio_CuevasN @castel_pau @MSKCancerCenter @DanaFarber @UCSFCancer @nyulangone https://t.co/NisCHasdTO