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Mashup Score: 10Follistatin From hiPSC-Cardiomyocytes Promotes Myocyte Proliferation in Pigs With Postinfarction LV Remodeling | Circulation Research - 6 day(s) ago
BACKGROUND: When human induced pluripotent stem cells (hiPSCs) that CCND2-OE (overexpressed cyclin-D2) were differentiated into cardiomyocytes (CCND2-OEhiPSC-CMs) and administered to the infarcted hearts of immunodeficient mice, the cells proliferated after administration and repopulated >50% of the scar. Here, we knocked out human leukocyte antigen class I and class II expression in CCND2-OEhiPSC-CMs (KO/OEhiPSC-CMs) to reduce the cells’ immunogenicity and then assessed the therapeutic efficacy of KO/OEhiPSC-CMs for the treatment of myocardial infarction. METHODS: KO/OEhiPSC-CM and wild-type hiPSC-CM (WThiPSC-CM) spheroids were differentiated in shaking flasks, purified, characterized, and intramyocardially injected into pigs after ischemia/reperfusion injury; control animals were injected with basal medium. Cardiac function was evaluated via cardiac magnetic resonance imaging, and cardiomyocyte proliferation was assessed via immunostaining and single-nucleus RNA sequencing. RESULTS:
Source: www.ahajournals.orgCategories: General Medicine News, General NewsTweet
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Mashup Score: 8Disease trajectories following myocardial infarction: insights from process mining of 145 million hospitalisation episodes - 1 month(s) ago
These results provide an opportunity for early intervention targets for survivors of MI—such as increased focus on the psychological and behavioural pathways—to mitigate ongoing adverse disease trajectories, multimorbidity, and premature mortality.
Source: www.thelancet.comCategories: General Medicine News, CardiologistsTweet-
By process mining 145 million hospitalisations we identified 28799 unique sequences of disease accrual, occurring more frequently & with higher mortality following hospitalisation for #heartattack than matched controls. @eBioMedicine https://t.co/ZzS8cHNHnn
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Mashup Score: 26History of COVID-19 found to double long-term risk of heart attack, stroke and death - 3 month(s) ago
A history of COVID-19 can double the risk of heart attack, stroke or death according to new research led by Cleveland Clinic and the University of Southern California.
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet-
History of COVID-19 found to double long-term risk of #heartAttack, stroke and death https://t.co/jUSMET9NBN
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Mashup Score: 53First aid for heart attack: Cardiologist Deepak Krishnamurthy explains what to do | Watch - 4 month(s) ago
In the video series, Dr Krishnamurthy explained the critical aspects of recognising the heart attack, first aid for it, hospital selection, treatment of heart attack, and physical activity and medication after heart attack.
Source: www.livemint.comCategories: General Medicine News, CardiologistsTweet-
#HeartAttack https://t.co/y0ZGMS7pjU
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Mashup Score: 13
The patient-tailored, medical decision support ARTEMIS-POC algorithm applied with a single POC hs-cTnI measurement allows for very rapid, safe, and more efficient direct rule-out of myocardial infarction than guideline-recommended pathways. It has the potential to expedite the safe discharge of low-risk patients from the emergency department including early presenters with symptom onset less than 3 h at the time of admission and might open new opportunities for the triage of patients with suspected myocardial infarction even in ambulatory, preclinical, or geographically isolated care settings.
Source: www.thelancet.comCategories: General Medicine News, CardiologistsTweet-
An improved algorithm using point-of-care hs troponin to rapidly rule-out #heartattack @LancetDigitalH https://t.co/AWR1uAEQbD
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Mashup Score: 29Research team discovers how Copaxone protects the heart muscle and improves its function after heart attack - 5 month(s) ago
In the late 1960s, three Weizmann Institute of Science researchers developed several protein-like molecules, called copolymers, that they believed would produce a disease similar to multiple sclerosis …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet-
Research team discovers how Copaxone protects the heart muscle and improves its function after #heartAttack @NatureCVR https://t.co/jZWls4UGdT
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Mashup Score: 27
Platelets are circulating cell fragments known to clump up and form blood clots that stop bleeding in injured vessels. Cardiologists have long known that platelets can become “hyperreactive” to cause …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet-
Blood platelet score detects previously unmeasured risk of #heartAttack and stroke @nyulangone @NatureComms https://t.co/Xy8OcGEmWm
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Mashup Score: 18
AbstractBackground. Older people less frequently receive invasive coronary angiography (ICA) for NSTEMI than younger patients. We describe care, ICA data,
Source: academic.oup.comCategories: General Medicine News, CardiologistsTweet-
Our study across 59 countries found people aged ≥75 years with NSTEMI #heartattack , compared with younger patients, less often received invasive coronary angio & guideline-recommended care, & had worse short-term outcomes @Age_and_Ageing https://t.co/mvEaRPvWWA
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Mashup Score: 12
BackgroundA growing population of patients with chronic kidney disease (CKD) presents with non–ST‐segment–elevation myocardial infarction, although little is known about their longer‐term mortality…
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Impact of Chronic Kidney Disease on the Processes of Care & Long‐Term Mortality of NSTEMI #heartattack :Nationwide Cohort Study @JAHA_AHA by @mmamas1973 & team https://t.co/16yLFVBgXn
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Mashup Score: 12
BackgroundA growing population of patients with chronic kidney disease (CKD) presents with non–ST‐segment–elevation myocardial infarction, although little is known about their longer‐term mortality…
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Impact of Chronic Kidney Disease on the Processes of Care & Long‐Term Mortality of NSTEMI #heartattack :Nationwide Cohort Study @JAHA_AHA by @mmamas1973 & team https://t.co/16yLFVBgXn
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#HeartAttack recovery in pigs improved with heart muscle cell spheroids from human-induced pluripotent stem cells, enhancing endogenous cell proliferation and reducing infarct size. Potential for clinical translation. https://t.co/2uecw3jHht https://t.co/f7dKkT2XPN