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Mashup Score: 0Pathogenic Germline Mutations Far More Common in Lung Cancer Than Previously Thought - 2 year(s) ago
New research presented during the August ASCO Plenary Series showed that about 1 of every 7 patients with lung cancer harbored a pathogenic germline mutation—the vast majority of which were clinically actionable.
Source: ASCO Daily NewsCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Point/Counterpoint: Is It Time for Universal Germline Genetic Testing for all GI Cancers? - 2 year(s) ago
Use of germline genetic testing among patients with cancer is increasing because of (1) the availability of multigene panel tests that include multiple cancer susceptibility genes in a single test, (2) decreased costs of these tests and improvements in insurance coverage, and (3) US Food and Drug Administration–approval of genotype-directed therapies such as poly(ADP-ribose) polymerase inhibitors…
Source: Journal of Clinical OncologyCategories: Hem/Oncs, Latest HeadlinesTweet-
I'll just leave this right here re universal #germline testing (at least in GI cancers) So much of the literature, rightly, focuses on the "pros," but there are real-world considerations that often get forgotten in the excitement to "test everyone" https://t.co/5tTFzhK7L1 https://t.co/cYo6pvDqx1
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Mashup Score: 1Program Guide – ASCO Meeting Program Guide - 2 year(s) ago
AuthorsSteven SorscherWake Forest School of Medicine, Winston-Salem, NCSteven Sorscher, Jaclyn LoPiccolo, Elaine Chen, Brandie Heald, Scott T. Michalski, Sarah M. Nielsen, Robert Luke Nussbaum, Renato G. Martins, Edward D. EsplinOrganizationsWake Forest School of Medicine, Winston-Salem, NC, Dana–Farber Cancer Institute, Boston, MA, Invitae, San Francisco, CA, University of Washington, Seattle,…
Source: meetings.asco.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
‼️ The August #ASCOPlenarySeries abstract on pathogenic #germline variants in pts w #lungcancer is now available. 📺 Tune in to the live presentation by Dr. Renato Martins TOMORROW, 8/16, @ 3 PM ET View abstract ➡️ https://t.co/mUJGlAgUGC #lcsm @OncoAlert @VCUMassey https://t.co/hXL7iAscb6
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Mashup Score: 4The impact of rare germline variants on human somatic mutation processes - Nature Communications - 2 year(s) ago
The impact of germline variants on somatic alterations in cancer remains to be explored in large-scale datasets. Here, the authors study the association of rare germline variants with somatic mutational processes in more than 15,000 tumors, and reveal that damaging variants in newly-identifed genes are prevalent in the population.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Study of rare #germline variants in more than 15,000 #tumours reveals their impact on #somatic mutational processes and their prevalence in the population #CancerResearch by @Mischan11 @FranSupek @BenLehner @CRGenomica @IRBBarcelona @natrescancer https://t.co/LTKLi1NCQt https://t.co/9LQhNOobbq
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Mashup Score: 12Germline Findings Among Tumors From Cancer Types Lacking Hereditary Testing Guidelines - 2 year(s) ago
This cross-sectional study examines the prevalence of germline findings in patients undergoing tumor/normal matched sequencing among cancer types lacking guidelines.
Source: jamanetwork.comCategories: Latest Headlines, Oncologists1Tweet-
RT @ADesaiMD: "#Germline Findings Among #Cancer Types Lacking Hereditary Testing Guidelines" https://t.co/G11gWz8aJw @JAMANetworkOpen @MDA…
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Mashup Score: 11Germline Findings Among Tumors From Cancer Types Lacking Hereditary Testing Guidelines - 2 year(s) ago
This cross-sectional study examines the prevalence of germline findings in patients undergoing tumor/normal matched sequencing among cancer types lacking guidelines.
Source: jamanetwork.comCategories: Latest Headlines, UrologyTweet-
RT @ADesaiMD: "#Germline Findings Among #Cancer Types Lacking Hereditary Testing Guidelines" https://t.co/G11gWz8aJw @JAMANetworkOpen @MDA…
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Mashup Score: 9Germline Findings Among Tumors From Cancer Types Lacking Hereditary Testing Guidelines - 2 year(s) ago
This cross-sectional study examines the prevalence of germline findings in patients undergoing tumor/normal matched sequencing among cancer types lacking guidelines.
Source: jamanetwork.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @ADesaiMD: "#Germline Findings Among #Cancer Types Lacking Hereditary Testing Guidelines" https://t.co/G11gWz8aJw @JAMANetworkOpen @MDA…
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Mashup Score: 6Germline Findings Among Tumors From Cancer Types Lacking Hereditary Testing Guidelines - 2 year(s) ago
This cross-sectional study examines the prevalence of germline findings in patients undergoing tumor/normal matched sequencing among cancer types lacking guidelines.
Source: jamanetwork.comCategories: Latest Headlines, Oncologists1Tweet-
RT @ADesaiMD: "#Germline Findings Among #Cancer Types Lacking Hereditary Testing Guidelines" https://t.co/G11gWz8aJw @JAMANetworkOpen @MDA…
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Mashup Score: 2Germline Findings Among Tumors From Cancer Types Lacking Hereditary Testing Guidelines - 2 year(s) ago
This cross-sectional study examines the prevalence of germline findings in patients undergoing tumor/normal matched sequencing among cancer types lacking guidelines.
Source: jamanetwork.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @ADesaiMD: "#Germline Findings Among #Cancer Types Lacking Hereditary Testing Guidelines" https://t.co/G11gWz8aJw @JAMANetworkOpen @MDA…
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Mashup Score: 4
FDA approves olaparib for adjuvant treatment of high-risk early breast cancer
Categories: Hem/Oncs, Latest HeadlinesTweet-
This is great news for #BRCA carriers with high-risk early #BreastCancer with important clinical implications including widespread #germline testing (and all its associated organizational issues) @OncoAlert #bcsm #olaparib @FDAOncology @US_FDA https://t.co/E1eqGKSUkJ https://t.co/0WbcEyWofB
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❗ #ASCODailyNews covers the latest #ASCOPlenarySeries study: About 1 of every 7 pts w/ lung cancer harbored a pathogenic #germline mutation, suggesting germline testing should be considered, along with exploration of targeted therapies: https://t.co/QN2hBoXJLd #lcsm