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Mashup Score: 34NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer - 15 hour(s) ago
PURPOSE The anti-NECTIN4 antibody-drug conjugate enfortumab vedotin (EV) is approved for patients with metastatic urothelial cancer (mUC). However, durable benefit is only achieved in a small, yet uncharacterized patient subset. NECTIN4 is located on chromosome 1q23.3, and 1q23.3 gains represent frequent copy number variations (CNVs) in urothelial cancer. Here, we aimed to evaluate NECTIN4 amplifications as a genomic biomarker to predict EV response in patients with mUC. MATERIALS AND METHODS We established a NECTIN4-specific fluorescence in situ hybridization (FISH) assay to assess the predictive value of NECTIN4 CNVs in a multicenter EV-treated mUC patient cohort (mUC-EV, n = 108). CNVs were correlated with membranous NECTIN4 protein expression, EV treatment responses, and outcomes. We also assessed the prognostic value of NECTIN4 CNVs measured in metastatic biopsies of non–EV-treated mUC (mUC-non-EV, n = 103). Furthermore, we queried The Cancer Genome Atlas (TCGA) data sets (10,712
Source: ascopubs.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 34NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer - 1 day(s) ago
PURPOSE The anti-NECTIN4 antibody-drug conjugate enfortumab vedotin (EV) is approved for patients with metastatic urothelial cancer (mUC). However, durable benefit is only achieved in a small, yet uncharacterized patient subset. NECTIN4 is located on chromosome 1q23.3, and 1q23.3 gains represent frequent copy number variations (CNVs) in urothelial cancer. Here, we aimed to evaluate NECTIN4 amplifications as a genomic biomarker to predict EV response in patients with mUC. MATERIALS AND METHODS We established a NECTIN4-specific fluorescence in situ hybridization (FISH) assay to assess the predictive value of NECTIN4 CNVs in a multicenter EV-treated mUC patient cohort (mUC-EV, n = 108). CNVs were correlated with membranous NECTIN4 protein expression, EV treatment responses, and outcomes. We also assessed the prognostic value of NECTIN4 CNVs measured in metastatic biopsies of non–EV-treated mUC (mUC-non-EV, n = 103). Furthermore, we queried The Cancer Genome Atlas (TCGA) data sets (10,712
Source: ascopubs.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 34NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer - 1 day(s) ago
PURPOSE The anti-NECTIN4 antibody-drug conjugate enfortumab vedotin (EV) is approved for patients with metastatic urothelial cancer (mUC). However, durable benefit is only achieved in a small, yet uncharacterized patient subset. NECTIN4 is located on chromosome 1q23.3, and 1q23.3 gains represent frequent copy number variations (CNVs) in urothelial cancer. Here, we aimed to evaluate NECTIN4 amplifications as a genomic biomarker to predict EV response in patients with mUC. MATERIALS AND METHODS We established a NECTIN4-specific fluorescence in situ hybridization (FISH) assay to assess the predictive value of NECTIN4 CNVs in a multicenter EV-treated mUC patient cohort (mUC-EV, n = 108). CNVs were correlated with membranous NECTIN4 protein expression, EV treatment responses, and outcomes. We also assessed the prognostic value of NECTIN4 CNVs measured in metastatic biopsies of non–EV-treated mUC (mUC-non-EV, n = 103). Furthermore, we queried The Cancer Genome Atlas (TCGA) data sets (10,712
Source: ascopubs.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2Journalistic interventions matter: Understanding how Americans perceive fact-checking labels | HKS Misinformation Review - 2 day(s) ago
While algorithms and crowdsourcing have been increasingly used to debunk or label misinformation on social media, such tasks might be most effective when performed by professional fact checkers or journalists. Drawing on a national survey (N = 1,003), we found that U.S. adults evaluated fact-checking labels created by professional fact checkers as more effective than labels by algorithms and
Source: misinforeview.hks.harvard.eduCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1Why do so many of America’s white evangelicals support Putin? - ABC Religion & Ethics - 7 day(s) ago
Evangelicals make up one quarter of all American voters. Hence the stances they adopt matter to America’s domestic and international politics. Not only did 84 per cent of white evangelicals vote for Donald Trump in 2020, but many evangelical leaders have voiced support for Vladimir Putin for nearly a decade. Why? Those who believe that America’s white evangelicals have embraced Putin due to some fundamentalist proclivity for authoritarianism have the story backwards.
Source: www.abc.net.auCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3Timothy Edward Quill, M.D. | UR Medicine - 7 day(s) ago
The University of Rochester Medical Center (URMC) is one of the nation’s leading academic medical centers. It forms the centerpiece of the University of Rochester’s health research, teaching and patient care missions. The University of Rochester Medical Center is a private, coeducational, nonsectarian, and nonprofit research university.
Source: www.urmc.rochester.eduCategories: General Medicine News, Hem/OncsTweet-
@Dr_RShatsky @EnriqueSoto8 @JournalCancer @acsglobal @YoungSIOG @SIOGorg @marklewismd @WilliamDale_MD @ConquerCancerFd @cityofhope Rebecca, I found the same 🙏🏻🙏🏻🙏🏻 The way to counter it, genius lesson from #pallcare legend Tim Quill👇: Elicit in detail what’s most important to patient👉then explain how various choices may impact it, in front of family👉Family listen better @gary_lyman https://t.co/CvI6spdzcC
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Mashup Score: 4
Johnson laid down the gauntlet to the critics in his own party, noting that “history judges us for what we do.”
Source: www.newsweek.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 987A Test of Strength - 12 day(s) ago
Biden stands with America’s allies. Trump doesn’t.
Source: www.theatlantic.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3Somatic mutation rates scale with lifespan across mammals - 15 day(s) ago
Nature – Whole-genome sequencing is used to analyse the landscape of somatic mutation in intestinal crypts from 16 mammalian species, revealing that rates of somatic mutation inversely scale with…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 239FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity - 3 month(s) ago
Nature Communications – Neutrophils are versatile immune cells that may also serve as antigen-presenting cells (APC). Here the authors show that engaging FcγRs on neutrophils with immune…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
RT @Markuseckstein3: We are happy to share our new study published today @JCO_ASCO (👉 https://t.co/NJtUVRVJ0Q) on the role of NECTIN4 ampli…