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Mashup Score: 9Tracking the evolution of esophageal squamous cell carcinoma under dynamic immune selection by multi-omics sequencing - Nature Communications - 1 year(s) ago
It is essential to understand heterogeneity and evolution at different omics levels in oesophageal squamous cell carcinoma (ESCC). Here, the authors use multi-omics to analyse heterogeneity and evolution in ESCC patient samples, and characterise the levels of immune infiltration as well as selective pressure from the tumour microenvironment.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 2
ASCO GU 2023 study design for the EVOLUTION trial, phase II study of 177Lu-PSMA-617 in combination with ipilimumab and nivolumab versus 177Lu-PSMA-617 alone in patients with metastatic castration-resistant prostate cancer (mCRPC), EVOLUTION trial.
Source: www.urotoday.comCategories: General Medicine News, Latest HeadlinesTweet-
#EVOLUTION phase II study of radionuclide 177Lu-PSMA-617 vs 177Lu-PSMA-617 in Combination with Ipilimumab and Nivolumab for men with #mCRPC (ANZUP 2001). Presented by @SandhuShahneen @PeterMacCC. @ASCO #GU23 written coverage by @rksayyid @UofT > https://t.co/3gayqlwJWL https://t.co/0vS7Pf4H0C
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Mashup Score: 5Study clarifies mystery of crocodilian hemoglobin - 1 year(s) ago
The crocodilian edition of hemoglobins — the scuba tanks of the blood — work so well that crocs can go hours without air. The hyper-efficiency of that adaptation has led some biologists to wonder why, of all the jawed vertebrates, crocodilians were the lone group to hit on such an optimal solution to making the most of a breath. After resurrecting the hemoglobin of ancient crocodilian ancestors,…
Source: EurekAlert!Categories: General Medicine News, Latest HeadlinesTweet-
Experiments on ancient #proteins find #mutations more numerous, nuanced than once thought @UNLincoln #evolution #hemoglobin #evolutionarygenetics https://t.co/WU4orNjhER
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Mashup Score: 1
As part of our 5-year strategy, we aim to exploit our understanding of cancer’s complexity, ecosystems and evolution to create innovative new ways to target the disease – drawing on ideas from across the ICR’s discovery science.
Source: www.icr.ac.ukCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Our new strategy will exploit our understanding of #Cancer's complexity, ecosystems and #Evolution to create innovative ways to target the disease – drawing on ideas from across our #DiscoveryScience. Read more on how we will target weaknesses in cancer: https://t.co/rZis4zIco1 https://t.co/7O4qMDdqyR
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Mashup Score: 3It would take 23 million years for evolution to replace Madagascar’s endangered mammals - 1 year(s) ago
90% of the plants and animals on Madagascar are found nowhere else on Earth, but this treasure trove of evolution is under serious threat due to habitat loss, over-hunting, and climate change. In this study, researchers examined how long it took Madagascar’s unique modern mammal species to emerge and estimated how long it would take for a similarly complex set of new mammal species to evolve in…
Source: EurekAlert!Categories: General Medicine News, Latest HeadlinesTweet-
It would take 23 million years for #evolution to replace #Madagascar’s #endangered mammals @FieldMuseum #extinction #evolutionarygenetics #animalscience https://t.co/JIlttTSall
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Mashup Score: 0Genes - 1 year(s) ago
Listen to this episode from Talking With Cancer on Spotify. Katie is feeling like one of the family at the ICR. She was thrilled to speak to another one of their fascinating researchers, Professor Trevor Graham who has moved his lab over from Bart’s, looking at the evolution of cancer genes. He shares his knowledge around how cancer genes evolve and how and why they can become drug resistant. He…
Source: SpotifyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
🎧 On the latest episode of #TalkingWithCancer, Professor @trevoragraham, Director of our Centre for #Evolution and #Cancer (@CEC_ICR), shares more on his work on understanding #CancerEvolution in #BowelCancer. Listen here: https://t.co/qm9lpdezkF https://t.co/GlTGRUHUFj
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Mashup Score: 3The clever glue keeping the cell’s moving parts connected - 1 year(s) ago
Proteins in the cell can form tiny liquid droplets that act as a smart molecular glue, discover researchers. Clinging to the ends of filaments called microtubules, this smart liquid ensures the nucleus is correctly positioned for cell division. The findings explain the long-standing mystery of how moving protein structures of the cell’s machinery are coupled together.
Source: EurekAlert!Categories: General Medicine News, Latest HeadlinesTweet-
Optimized by nature over 100 million years of #evolution, this smart liquid provides a crucial coupling that ensures #celldivision correctly proceeds @psich_en #proteininteractions #microtubules #discoveryresearch #structuralbiology https://t.co/Lj8k04bbBq
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Mashup Score: 0Source: academic.oup.comCategories: Genetics, Latest HeadlinesTweet
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Iyengar and Wagner perform directed #evolution of GFP under low and high cellular concentrations of Hsp90, revealing that the role of a chaperone for adaptive evolution depends on the organism and the trait being studied. #GENETICS | https://t.co/LDsPWkkkhv https://t.co/jjuSiR1V1K
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Mashup Score: 0Spatial biology of cancer evolution - Nature Reviews Genetics - 1 year(s) ago
In this Review, the authors discuss our latest understanding of the spatial aspects of cancer evolution, including the roles of cancer subclonal structure, tissue architecture, and interactions between cancer cells and diverse cell types of the microenvironment at local and distant sites.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Thoughtful review on how spatial #tech including #cycif can advance our knowledge of tumor #evolution. Thousands of archival tumor blocks await https://t.co/oKezadY3ru
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Mashup Score: 2
Discovery of world’s oldest DNA breaks record by one million years Two-million-year-old DNA has been identified for the first time – opening a ‘game-changing’ new chapter in the history of evolution. Microscopic fragments of environmental DNA were found in Ice Age sediment in northern Greenland. Using cutting-edge technology, researchers discovered the fragments are one million years older…
Source: EurekAlert!Categories: General Medicine News, Latest HeadlinesTweet-
Two-million-year-old #DNA has been identified for the first time - opening a ‘game-changing’ new chapter in the history of #evolution @stjohnscam #sediment #animalresearch #discoveryresearch https://t.co/5bdtaLM2BR
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#MultiOmics analysis of #EsophagealCancer characterises #heterogeneity, #evolution, #immune infiltration across sites, and selective pressure from the tumour #microenvironment #CancerResearch @natrescancer https://t.co/QuGC704GcA https://t.co/n2rdZ3xygd