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Mashup Score: 1
Tissue homeostasis and the emergence of disease are controlled by changes in the proportions of resident and recruited cells, their organization into cellular neighbourhoods, and their interactions with acellular tissue components. Highly multiplexed tissue profiling (spatial omics)[1][1] makes it possible to study this microenvironment in situ , usually in 4-5 micron thick sections (the standard histopathology format)[2][2]. Microscopy-based tissue profiling is commonly performed at a resolution sufficient to determine cell types but not to detect subtle morphological features associated with cytoskeletal reorganisation, juxtracrine signalling, or membrane trafficking[3][3]. Here we describe a high-resolution 3D imaging approach able to characterize a wide variety of organelles and structures at sub-micron scale while simultaneously quantifying millimetre-scale spatial features. This approach combines cyclic immunofluorescence (CyCIF) imaging[4][4] of over 50 markers with confocal mic
Source: www.biorxiv.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 38Starting Your Independent Research Laboratory - 25 day(s) ago
Correspondence to: Adrian Liston, PhD, Email Immunology Programme, The Babraham Institute, Cambridge, United Kingdom (A.L.). Département de Microbiologie, Infectiologie et Immunologie, Université de Montré al, Montreal, Quebec, Canada (S.L.). Opening up an independent research laboratory is the culmination of a decade or more of investment. Many of us dream of independence, the ability to guide new trainees and explore our own scientific passions. Some of us naively think we know how a laboratory runs
Source: www.ahajournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3Roswell Park Teams Report Latest Findings on Obesity & Cancer, Other High-Priority Research at AACR 2024 - 29 day(s) ago
Researchers from Roswell Park Comprehensive Cancer Center will share their latest findings with colleagues from around the world at the 2024 annual meeting of the American Association for Cancer Research (AACR) in San Diego, California, April 5-10. The event attracts more than 21,000 professionals from the oncology field, as well as patients, survivors and advocates.
Source: www.roswellpark.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3
In a zebrafish model of human cutaneous and acral melanomas, CRKL amplification causes tumours to favour a fin location, indicating that tumour location is determined by both the driver oncogenes and the pre-existing positional identity gene program.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0
Image information and view/download options.
Source: visualsonline.cancer.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 6To Fulfill Its Social Mission, Harvard Must Resist Social Pressures | Opinion | The Harvard Crimson - 4 month(s) ago
To Fulfill Its Social Mission, Harvard Must Resist Social Pressures | Opinion | The Harvard Crimson
Source: www.thecrimson.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Additivity predicts the efficacy of most approved combination therapies for advanced cancer - Nature Cancer - 5 month(s) ago
Palmer and colleagues present a computational model of drug additivity that can predict clinical efficacy for the majority of combination therapy trials in advanced cancer that led to US Food and Drug Administration approvals between 1995–2020.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Dana-Farber blindsided Brigham and Women’s. The blowback will be strong. - The Boston Globe - 8 month(s) ago
Brigham leaders were sure they had a deal to extend their partnership with the famed cancer institute. Then Dana-Farber bolted and struck a deal with Beth Israel Deaconess.
Source: www.bostonglobe.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Does triple-negative breast cancer (TNBC) subtyping inform on chances of achieving a pathologic complete response (pCR) and on the potential benefits of adding carboplatin to standard neoadjuvant chemotherapy?This prespecified secondary analysis of a …
Source: www.ncbi.nlm.nih.govCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0A joyous blood donation by two leaders who toiled to change the nation’s antiquated rules - The Boston Globe - 8 month(s) ago
New rules announced earlier this summer that open blood donation to millions of gay and bisexual men recently went into effect.
Source: www.bostonglobe.comCategories: Hem/Oncs, Latest HeadlinesTweet
Just look at this mind-blowing work from Clarence Yapp @sorger_peter @SantagataLab being presented at the plenary https://t.co/Ay0Nzxk7sZ