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Mashup Score: 1Direct and Indirect Regulators of Epithelial–Mesenchymal Transition–Mediated Immunosuppression in Breast Carcinomas - 3 year(s) ago
The epithelial-to-mesenchymal transition, which conveys epithelial (E) carcinoma cells to quasi-mesenchymal (qM) states, enables them to metastasize and acquire resistance to certain treatments. Murine tumors composed of qM mammary carcinoma cells assemble an immunosuppressive tumor microenvironment (TME) and develop resistance to anti-CTLA4 immune-checkpoint blockade (ICB) therapy, unlike their…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 8
This Perspective outlines the connections of epithelial–mesenchymal transition programmes to the stem cell state in both normal and cancer stem cells and discusses emerging concepts related to the heterogeneous and plastic cell states generated by an epithelial–mesenchymal transition that influence our understanding of cancer stem cell biology and cancer metastasis.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 4Volume 21 Issue 5, May 2021 - 3 year(s) ago
Volume 21 Issue 5, May 2021
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. A developmental programme known as epithelial-to-mesenchymal transition (EMT) plays a critical role during metastasis, promoting the loss of polarity and cell–cell adhesion and the acquisition of motile, stem-cell characteristics. Cells undergoing EMT or the reverse mesenchymal-to-epithelial…
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1ACMT - Overview - 3 year(s) ago
The ACMT Total Tox Course is a comprehensive review of the scope of emergency toxicology and will include cutting-edge interventions and management options for poisoned patients. Prominent experts in medical toxicology and emergency medicine will lead the course. The 3-day course (register for 1 day, 2 days, or all 3) will focus on medical toxicology…
Source: www.acmt.netCategories: Emergency Medicine, Latest HeadlinesTweet
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Mashup Score: 2Paramedics for Mental Health? - 3 year(s) ago
An innovative program sends mental health first responders out onto the streets.
Source: Psychiatric TimesCategories: Latest Headlines, PsychiatryTweet
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Mashup Score: 2
Long noncoding RNAs (LncRNAs) are essential epigenetic regulators with critical roles in tumor initiation and malignant progression; however, the mechanism by which aberrantly expressed lncRNA RP11-84E24.3 regulates the pathogenesis of glioma is not fully understood. Here, we investigate the function of lncRNA RP11-84E24.3 in glioma onset and progression as well as identify a molecular pathway…
Source: Journal of Neuro-OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0FDA Approves Philips HeartStart AEDs - 4 year(s) ago
The FDA has granted premarket approval for the Philips HeartStart FR3 and HeartStart FRx automated external defibrillators and accessories.
Categories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0Zeb2 drives invasive and microbiota-dependent colon carcinoma - 4 year(s) ago
Van Loo and colleagues report that loss of the Zeb2 regulator of epithelial-to-mesenchymal transition from the intestinal epithelium leads to inflammation, increased intestinal permeability and colorectal cancer development, which is enhanced by the resident intestinal microbiome.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2All-black ambulance service inspired today's EMS system - Scope - 4 year(s) ago
The Freedom House Ambulance Service helped establish the national training model for EMS programs, but abruptly shut down in 1975.
Source: ScopeCategories: Healthcare ProfessionalsTweet-
All-black ambulance service inspired today's EMS system | @MattEdwardsMD https://t.co/XbzySDDdr9 Pittsburgh's Freedom house ambulance project helped establish national training model for emergency medical service programs. #EMT #BlackHistoryMonth cc: @KPobgyndoc @yayayarndiva https://t.co/FCo7pYPo5w
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From the May issue: Direct and Indirect Regulators of #EpithelialMesenchymalTransition (#EMT)-mediated #Immunosuppression in Breast Carcinomas by Robert A. Weinberg and colleagues. @DongreAnushka @WhiteheadInst @MIT #BreastCancer #Immunology https://t.co/oX30HXNmww https://t.co/z2R8eQI9TA