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Mashup Score: 13Overcoming Hypoxia-Induced Apoptotic Resistance through Combinatorial Inhibition of GSK-3β and CDK1 - 5 month(s) ago
Findings elucidate a novel therapeutic strategy to overcome the inherent resistance of hypoxic cancer cells to cell death, by targeting two kinases not previously linked to cell death protection in hypoxic tumor microenvironments.
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 6Milademetan Plus ONC201 Could Represent Synergistic Combination in MDM2-overexpressing Solid Tumors - 7 month(s) ago
Ilyas Sahin, MD, details the preclinical findings from the study and highlighted how these data could help inform future studies for the treatment of patients with MDM2-overexpressing solid tumors.
Source: www.onclive.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Milademetan Plus ONC201 Could Represent Synergistic Combination in MDM2-overexpressing Solid Tumors https://t.co/GAtN0CZ5Po #eldeirylab #LegorretaCancerCenter @andrewgeorge00 @ilyassahinMD @shengliang15 @PinhoSchwermann @frandicris @BrownUCancer @BrownMedicine @BrownUniversity… https://t.co/dfQ2uiAaQk
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Mashup Score: 2
NKG2D-CAR T cells selectively eliminate senescent cells in aged animal models.
Source: www.science.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
Great presentation by @BrownUniversity rising senior undergraduate student Connor Purcell at #eldeirylab meeting this morning of recent paper in @ScienceTM NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates https://t.co/fh5eNWlvNj @BrownUCancer… https://t.co/LpAlraLKWF https://t.co/bXVO0yrjeZ
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Mashup Score: 0
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that has been implicated in numerous oncogenic processes. GSK-3 inhibitor elraglusib (9-ING-41) has shown promising preclinical and clinical antitumor activity across multiple tumor types. Despite promising early-phase clinical trial re …
Source: PubMedCategories: Latest Headlines, Oncologists2Tweet-
Our paper is now published @BrownUCancer #eldeirylab @BrownMedicine @BrownUPathoGP GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies & Synergizes with Anti-PD-L1 in Murine Model of Colorectal Cancer https://t.co/IWrucIU88e
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Mashup Score: 0Log in or sign up to view - 10 month(s) ago
See posts, photos and more on Facebook.
Source: www.facebook.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Spent some time on the bay with lab colleagues and collaborators #eldeirylab at The Warren Alpert Medical School of Brown University https://t.co/EIqSZVn8Ni
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Mashup Score: 0Swift & Sons | American Steakhouse | West Loop, Chicago IL - 11 month(s) ago
Swift & Sons is Chicago’s premier steakhouse with a modern twist.
Source: www.swiftandsonschicago.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Great to meet colleagues from O’Hara Pharmaceutical Co. In Japan at Swift & Sons https://t.co/28Unvn8ca1 to discuss collaboration with @BrownUCancer and #eldeirylab https://t.co/UiKrCgVowN
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Mashup Score: 3Give Now - 12 month(s) ago
Commit Your Gift Cancer Center Director’s Discretionary Fund Please enter an amount greater than $5.00 Gift Selection Select…
Source: bbis.advancement.brown.eduCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @weldeiry: Support cancer research in beautiful Rhode Island @BrownUCancer @BrownMedicine #eldeirylab https://t.co/3NPwP8PuIA https://t.…
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Mashup Score: 0The Role of Soluble Immune Checkpoints in Cancer Immunotherapy - 1 year(s) ago
Immune checkpoints (ICPs) are critical regulators of the immune system and are essential for self-tolerance and the prevention of chronic autoimmune inflammation. Soluble immune checkpoints (sICPs) are shed or secreted by multiple cell types including immune cells,…
Source: SpringerLinkCategories: Latest Headlines, Oncologists2Tweet-
Sharing chapter by amazing PhD student Kelsey Huntington @BrownUPathoGP #eldeirylab @BrownUCancer @BrownMedicine @BrownUniversity @BrownOncology @BrownHemOnc @BrownPhysicians @BrownUResearch The Role of Soluble Immune Checkpoints in Cancer Immunotherapy https://t.co/ogtPUEoEpO
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Mashup Score: 0
Penn State’s THON has raised yet another jaw-dropping amount of money.
Source: apple.newsCategories: Hem/Oncs, Latest HeadlinesTweet-
Another amazing year for THON - see how much they raised this year! https://t.co/vWqsNtsViU @BrownUCancer #HoiPolloi @ShiOnaCo @cailieburns @LauraKalafarski #eldeirylab @BrownMedicine @BrownUniversity @andrewgeorge00 @frandicris @carlsen_lindsey @BrownOncology @LanlanZhou… https://t.co/KXPOFKMRoR
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Mashup Score: 3Temozolomide combined with ipilimumab plus nivolumab enhances T cell killing of MGMT-expressing, MSS colorectal cancer cells - PubMed - 1 year(s) ago
Colorectal cancer (CRC) is the third most frequently diagnosed cancer and third-deadliest cancer globally. Over 95% of patients with metastatic CRC have tumors that are microsatellite stable (MSS) and do not respond to immune checkpoint inhibitors (ICI). Results from the 2022 MAYA clinical trial sug …
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
Sharing our preclinical results on colon cancer immunotherapy #eldeirylab @carlsen_lindsey @BrownUCancer Temozolomide combined with ipilimumab plus nivolumab enhances T cell killing of MGMT-expressing, MSS colorectal cancer cells - PubMed https://t.co/NmY4IM3wxI
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Reminded of a classic paper from the #eldeirylab that was ahead of its time👇 Overcoming Hypoxia-Induced Apoptotic Resistance through Combinatorial Inhibition of GSK-3β and CDK1 https://t.co/srOwmkzJON