• Mashup Score: 2

    AbstractAims. Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite significant progress in understanding the genetic aetiologies of

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    • Serine biosynthesis as a novel therapeutic target for DCM Phenotypic screening of iPSC-derived #cardiomyocytes suggests that modulation of serine biosynthesis pathway may be a potential novel therapeutic target for genetic #DCM. https://t.co/7J4eqLcYiA #EHJ @ESC_Journals https://t.co/ipkKUxkgwm

  • Mashup Score: 1

    Heart failure encompasses a heterogeneous set of clinical features that converge on impaired cardiac contractile function1,2 and presents a growing public health concern. Previous work has highlighted changes in both transcription and protein expression in failing hearts3,4, but may overlook molecular changes in less prevalent cell types. Here we identify extensive molecular alterations in…

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    • Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy | Nature #DCM #HCM https://t.co/JK9uDYgbXS

  • Mashup Score: 1

    February 11, 2022 – Black patients diagnosed with dilated cardiomyopathy (DCM) of unknown cause are more likely to have family members at risk of developing the heart muscle disease than families of white patients, according to results of a multi-site study led by researchers at The Ohio State University Wexner Medical Center and College of Medicine. Researchers studied the prevalence and risk of…

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    • @DAICeditor @OSUWexMed #Researchers estimated that 30% of patients with #DCM seen at a typical advanced #heartfailure program in the U.S. had at least one first-degree family member with DCM: https://t.co/SkbizZdpjz