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Mashup Score: 0Phase III clinical trial of autologous CD34 + cell transplantation to accelerate fracture nonunion repair - BMC Medicine - 7 month(s) ago
Background We previously demonstrated that CD34 + cell transplantation in animals healed intractable fractures via osteogenesis and vasculogenesis; we also demonstrated the safety and efficacy of this cell therapy in an earlier phase I/II clinical trial conducted on seven patients with fracture nonunion. Herein, we present the results of a phase III clinical trial conducted to confirm the results of the previous phase studies using a larger cohort of patients. Methods CD34 + cells were mobilized via administration of granulocyte colony-stimulating factor, harvested using leukapheresis, and isolated using magnetic cell sorting. Autologous CD34 + cells were transplanted in 15 patients with tibia nonunion and 10 patients with femur nonunion, who were followed up for 52 weeks post transplantation. The main outcome was a reduction in time to heal the tibia in nonunion patients compared with that in historical control patients. We calculated the required number of patients as 15 based on the
Source: bmcmedicine.biomedcentral.comCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 0Assumptions of Patient Perceptions Create Unnecessary Barriers to Palliative Care | ASH Clinical News | American Society of Hematology - 10 month(s) ago
Skip Nav Destination June 1, 2023 Khylia Marshall is a freelance journalist based in Tucson, Arizona. Palliative care (PC) remains underused both during and after treatment despite established benefits, including improved quality of…
Source: ashpublications.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0What are CAR-T Cell Therapies? - 10 month(s) ago
What are CAR-T Cell Therapies?Friends of Cancer Research
Source: YouTubeCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 12023 Global Life Sciences Outlook - 11 month(s) ago
The COVID-19 pandemic magnified the importance of digital advances as companies raced to meet the demand for new testing, vaccines, and treatments to combat the pandemic. However, with increased competition, a shifting regulatory landscape, and growing demands from patients and health care providers, life sciences companies face significant challenges and must find ways to differentiate…
Source: DeloitteCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 4Magnetic-activated cell sorting identifies a unique lung microbiome community - Microbiome - 11 month(s) ago
Background The advent of culture-independent, next-generation DNA sequencing has led to the discovery of distinct lung bacterial communities. Studies of lung microbiome taxonomy often reveal only subtle differences between health and disease, but host recognition and response may distinguish the members of similar bacterial communities in different populations. Magnetic-activated cell sorting has…
Source: BioMed CentralCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0
Anorexia is experienced by most people with lung cancer during the course of their disease and treatment. Anorexia reduces response to chemotherapy and the ability of patients to cope with, and complete their treatment leading to greater morbidity, poorer prognosis and outcomes. Despite the significant importance of cancer-related anorexia, current therapies are limited, have marginal benefits…
Source: journals.plos.orgCategories: Latest Headlines, PulmonologyTweet-
Phase II, double blind, #placebo controlled, multi-site #study to #evaluate the #safety, #feasibility and desirability of conducting a phase III study of #anamorelin for #anorexia in people with small #cell #lung #cancer: A study protocol (LUANA trial) https://t.co/e5M3sl9XgQ https://t.co/j49rPiNKCl
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Mashup Score: 4
Welcome! You are invited to join a webinar: Frontiers in Cardiovascular Science Seminar. After registering, you will receive a confirmation email about joining the webinar.
Source: ZoomCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 0Cell & Gene Therapies - Friends of Cancer Research - 12 month(s) ago
Quick Links Sign Up for Updates Solutions Register for the May 22nd Event Register Today for our upcoming hybrid meeting on May 22nd, The Next Generation of Cellular Therapies: A Blueprint to Accelerate Development. Cell and gene therapies are emerging therapies that represent a new treatment paradigm for many diseases including cancer. Friends of Cancer Research (Friends) supports…
Source: Friends of Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Muscle-invasive bladder cancer (BLCA) is an aggressive disease. Consensus BLCA transcriptomic subtypes have been proposed, with two major Luminal and Basal subgroups, presenting distinct molecular and clinical characteristics. However, how these distinct subtypes are regulated remains unclear. We hypothesized that epigenetic activation of distinct super-enhancers could drive the transcriptional…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0A twist of fate led to regenerative medicine » Center for Regenerative Biotherapeutics - 1 year(s) ago
A chance meeting on a student shuttle bus put Wenchun Qu, M.D., Ph.D., on a new direction that years later […]
Categories: General Medicine Journals and Societies, Latest HeadlinesTweet
A Phase III #clinicaltrial of autologous #CD34+ #cell #transplantation accelerates time to radiological #fracture nonunion repair by 2.8 times. https://t.co/HOZhbSWtyZ Kuroda, Niikura et al. from @KobeU_Global report of interest to @MSKmedBMC #orthotwitter #stemcell https://t.co/9EdmYzRowI