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    Minimal residual disease (MRD) entered the scientific lexicon in 1973, with the promise of immunotherapy to reduce tumour burden so that only MRD remained.1 The term has since taken on a different meaning in multiple myeloma to denote the persistence of low-level disease.

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    • MRD-guided treatment cessation in multiple myeloma - @bdermanmd #bmtsm #mmsm @TheLancetHaem https://t.co/WhV2MXTJnx

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    The primary goal of the initial treatment in systemic light chain amyloidosis is to obtain a rapid and profound haematological response as safely as possible, coupled with supportive care by a multidisciplinary team. The treatment landscape has evolved with the introduction of highly effective therapies targeting the plasma cell clones, which can attain high rates of haematological complete response with minimal treatment-related morbidity and mortality. Consequently, the role of high-dose melphalan followed by autologous haematopoietic cell transplantation (HDM-AHCT) is being analysed, particularly considering the absence of randomised controlled trial data supporting its superiority over standard-dose therapies in systemic light chain amyloidosis treatment.

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    • Role of autologous haematopoietic cell transplantation in the treatment of systemic light chain amyloidosis in the era of anti-CD38 monoclonal antibodies @rajshekharucms @MorieGertz #bmtsm #mmsm https://t.co/2QSsVcmDgw