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Mashup Score: 6The causal relationship between gut microbiota and constipation: a two-sample Mendelian randomization study - BMC Gastroenterology - 5 month(s) ago
Background Constipation is one of the most common gastrointestinal disorders afflicting the population, with recent observational studies implicating dysfunction of the gut microbiota in constipation. Despite observational studies indicating a relationship, a clear causality remains unclear. This study aims to use two-sample Mendelian randomization (MR) to establish a clearer causal relationship between the two. Methods A two-sample Mendelian randomization (MR) study was performed using the gut microbiota summary Genome-Wide Association Studies (GWAS) statistics from MiBioGen consortium (n = 13,266) and constipation GWAS summary statistics from the IEU OpenGWAS database. The causality between gut microbiota and constipation is primarily analyzed using the inverse-variance weighted (IVW) method and reinforced by an additional four methods, including MR-Egger, Weighted Median, Simple Mode, and Weighted Mode. Finally, funnel plot, heterogeneity test, horizontal pleiotropy test, and leave-
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Mashup Score: 6The causal relationship between gut microbiota and constipation: a two-sample Mendelian randomization study - BMC Gastroenterology - 6 month(s) ago
Background Constipation is one of the most common gastrointestinal disorders afflicting the population, with recent observational studies implicating dysfunction of the gut microbiota in constipation. Despite observational studies indicating a relationship, a clear causality remains unclear. This study aims to use two-sample Mendelian randomization (MR) to establish a clearer causal relationship between the two. Methods A two-sample Mendelian randomization (MR) study was performed using the gut microbiota summary Genome-Wide Association Studies (GWAS) statistics from MiBioGen consortium (n = 13,266) and constipation GWAS summary statistics from the IEU OpenGWAS database. The causality between gut microbiota and constipation is primarily analyzed using the inverse-variance weighted (IVW) method and reinforced by an additional four methods, including MR-Egger, Weighted Median, Simple Mode, and Weighted Mode. Finally, funnel plot, heterogeneity test, horizontal pleiotropy test, and leave-
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A study published in #BMCGastroEnterol discusses specific microbe families associated with constipation, which affords fresh insights into the pathogenesis of the disease and the possibility of developing treatment strategies. https://t.co/obsj4466H2
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Mashup Score: 2Morning light treatment for inflammatory bowel disease: a clinical trial - BMC Gastroenterology - 9 month(s) ago
Background Inflammatory bowel disease (IBD) affects over 3 million Americans and has a relapsing and remitting course with up to 30% of patients experiencing exacerbations each year despite the availability of immune targeted therapies. An urgent need exists to develop adjunctive treatment approaches to better manage IBD symptoms and disease activity. Circadian disruption is associated with increased disease activity and may be an important modifiable treatment target for IBD. Morning light treatment, which advances and stabilizes circadian timing, may have the potential to improve IBD symptoms and disease activity, but no studies have explored these potential therapeutic benefits in IBD. Therefore, in this study, we aim to test the effectiveness of morning light treatment for patients with IBD. Methods We will recruit sixty-eight individuals with biopsy-proven IBD and clinical symptoms and randomize them to 4-weeks of morning light treatment or 4-weeks of treatment as usual (TAU), wit
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Morning light treatment may be an acceptable, feasible, and effective adjunctive treatment for individuals with active inflammatory bowel disease, finds a Study Protocol published in #BMCGastroEnterol https://t.co/E7X2sY7jdL
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Mashup Score: 4The association between dietary vitamin B1 intake and constipation: a population-based study - BMC Gastroenterology - 9 month(s) ago
Background Numerous researches have indicated a correlation between the intake of dietary micronutrients and the occurrence of constipation. Nevertheless, the correlation between constipation and vitamin B1 remains uninvestigated. The main aim of this research was to examine the association between chronic constipation and the consumption of vitamin B1 in the diet among adult participants of the National Health and Nutrition Examination Survey (NHANES). Methods This study used data from the NHANES, a survey on health and nutrition conducted between 2005 and 2010. The respondents’ dietary information was gathered by utilizing the 24-hour dietary records. Various statistical analyses, such as multiple logistic regression, subgroup analysis, and curve-fitting analysis, were employed to investigate the correlation between dietary intake of vitamin B1 and chronic constipation. Results In the trial, there were 10,371 participants, out of which 1,123 individuals (10.8%) were identified as hav
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A study published in #BMCGastroEnterol suggests that enhanced intake of vitamin B1 through diet may improve intestinal motility and alleviate constipation symptoms. https://t.co/y8wojNZD5p
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Mashup Score: 1Exploring the association between dietary fiber intake and hepatic steatosis: insights from NHANES - BMC Gastroenterology - 9 month(s) ago
Purpose The link between dietary fiber intake and Non-alcoholic fatty liver disease (NAFLD) is under exploration, yielding inconsistent findings. Considering the limitations of previous research and the significance of dietary fiber in hepatic steatosis, this study investigates the association between dietary fiber intake and Controlled Attenuation Parameter (CAP) among 5935 participants from the National Health and Nutrition Examination Survey (NHANES). Materials and methods Multivariable regression was used to evaluate the association between dietary fiber intake and CAP. Smoothed curve fitting and threshold effect analysis techniques were applied to illustrate non-linear relationships. Results After adjusting for other variables, a negative correlation emerged between dietary fiber intake and CAP. Subgroup analysis by gender and race/ethnicity revealed a sustained negative association between dietary fiber intake and CAP among females and Whites. Additionally, an inverted U-shaped r
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A study published in #BMCGastroEnterol indicates that in the majority of Americans, there is an inverse relationship between dietary fiber intake and hepatic steatosis. https://t.co/46f4g8fwNL
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Mashup Score: 1Dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis: evaluation by elastography/Fibroscan - BMC Gastroenterology - 10 month(s) ago
One of the proposed mechanisms by which nutrition influences the progression of hepatic steatosis to fibrosis is inflammation. The study investigated how the inflammatory potential of the diet affects the risk of liver damage in patients with nonalcoholic fatty liver disease (NAFLD), a condition where fat accumulates in the liver. This cross-sectional study included 170 outpatients with newly diagnosed NAFLD. This study used a device called Fibroscan® to measure the degree of liver fibrosis, which is the scarring of the liver tissue due to chronic inflammation. The study also used a tool called the Dietary Inflammatory Index (DII) to measure the inflammatory potential of the diet based on the intake of different foods and nutrients. In the findings of the study, patients with more severe fat accumulation in the liver (hepatic steatosis) had higher DII scores, meaning they had more inflammatory diets. The study also found that higher DII scores were associated with higher weight and bod
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A study published in #BMCGastroEnterol suggests that eating less inflammatory foods may help prevent or slow down the progression of hepatic steatosis and liver in patients with nonalcoholic fatty liver disease. https://t.co/kQAX2wryVf
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Mashup Score: 2A comprehensive study on non-cancer-related mortality risk factors in elderly gastric cancer patients post-curative surgery - BMC Gastroenterology - 12 month(s) ago
Background The increasing incidence of gastric cancer in the elderly underscores the need for an in-depth understanding of the challenges and risks associated with surgical interventions in this demographic. This study aims to investigate the risk factors and prognostic indicators for non-cancer-related mortality following curative surgery in elderly gastric cancer patients. Methods This retrospective analysis examined 684 patients with pathological Stage I—III gastric cancer who underwent curative resection between January 2012 and December 2021. The study focused on patients aged 70 years and above, evaluating various clinical and pathological variables. Univariate analysis was utilized to identify potential risk factors with to non-cancer-related mortality and to access prognostic outcomes. Results Out of the initial 684 patients, 244 elderly patients were included in the analysis, with 33 succumbing to non-cancer-related causes. Univariate analysis identified advanced age (≥ 80 yea
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A study published in #BMCGastroEnterol finds that advanced age (80 and above), high comorbidity index score, and lower BMI (less than 18.5) elevate the risk of non-cancer-related mortality in elderly gastric cancer patients post surgery. https://t.co/be8hMaiLOO
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Mashup Score: 0
Background and aims Anxiety and depression symptoms are common in IBD population, both adult and pediatric patients. Increased psychological distress might contribute to initiation and switching to biologic therapy in adult patients with IBD or other chronic inflammatory diseases. Aim of the present study are to evaluate anxiety and depression symptoms in IBD pediatric patients with disease remission and investigate their role in initiation or switching to biologic therapy. Methods We performed a retrospective analysis on IBD pediatric patients, assessing for anxiety (GAD-7) and depression (PHQ-9) symptoms. Demographic and disease characteristics were obtained from medical records. Results Eighty-six patients [31 (36%) females – mean age = 15.6 (SD = 2.8) years] were included. Patients scored above cut-off (> 10) on PHQ-9 and GAD-7 were 17 (19.7%) and 18 (20.9%), respectively. No differences were found between UC and CD patients. Baseline clinically relevant depression symptoms were si
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A study published in #BMCGastroEnterol finds that anxiety and depression symptoms are common in the pediatric inflammatory bowel disease population, even with disease remission, and such patients are at increased risk of switching to biologic therapy. https://t.co/8uqpJ9VWUL
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Mashup Score: 0
Background and aims Anxiety and depression symptoms are common in IBD population, both adult and pediatric patients. Increased psychological distress might contribute to initiation and switching to biologic therapy in adult patients with IBD or other chronic inflammatory diseases. Aim of the present study are to evaluate anxiety and depression symptoms in IBD pediatric patients with disease remission and investigate their role in initiation or switching to biologic therapy. Methods We performed a retrospective analysis on IBD pediatric patients, assessing for anxiety (GAD-7) and depression (PHQ-9) symptoms. Demographic and disease characteristics were obtained from medical records. Results Eighty-six patients [31 (36%) females – mean age = 15.6 (SD = 2.8) years] were included. Patients scored above cut-off (> 10) on PHQ-9 and GAD-7 were 17 (19.7%) and 18 (20.9%), respectively. No differences were found between UC and CD patients. Baseline clinically relevant depression symptoms were si
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A study published in #BMCGastroEnterol finds that anxiety and depression symptoms are common in the pediatric inflammatory bowel disease population, even with disease remission, and such patients are at increased risk of switching to biologic therapy. https://t.co/8uqpJ9VWUL
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Mashup Score: 0Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review - BMC Gastroenterology - 1 year(s) ago
Gastrointestinal Tuberculosis (GITB) and Crohn’s disease (CD) are both chronic granulomatous diseases with a predilection to involve primarily the terminal ileum. GITB is often considered a disease of the developing world, while CD and inflammatory bowel disease are considered a disease of the developed world. But in recent times, the epidemiology of both diseases has changed. Differentiating GITB from CD is of immense clinical importance as the management of both diseases differs. While GITB needs anti-tubercular therapy (ATT), CD needs immunosuppressive therapy. Misdiagnosis or a delay in diagnosis can lead to catastrophic consequences. Most of the clinical features, endoscopic findings, and imaging features are not pathognomonic for either of these two conditions. The definitive diagnosis of GITB can be clinched only in a fraction of cases with microbiological positivity (acid-fast bacilli, mycobacterial culture, or PCR-based tests). In most cases, the diagnosis is often based on co
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A Review published in #BMCGastroEnterol summarizes the evidence and strategies for distinguishing gastrointestinal tuberculosis from Crohn’s disease. https://t.co/0bg2Bk4kx5
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A study published in #BMCGastroEnterol discusses specific microbe families associated with constipation, which affords fresh insights into the pathogenesis of the disease and the possibility of developing treatment strategies. https://t.co/obsj4466H2