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Mashup Score: 5Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort - 7 month(s) ago
Background Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurogenerative disease caused by combined genetic susceptibilities and environmental exposures. Identifying and validating these exposures are of paramount importance to modify disease risk. We previously reported that persistent organic pollutants (POPs) associate with ALS risk and survival and aimed to replicate these findings in a new cohort. Method Participants with and without ALS recruited in Michigan provided plasma samples for POPs analysis by isotope dilution with triple quadrupole mass spectrometry. ORs for risk models and hazard ratios for survival models were calculated for individual POPs. POP mixtures were represented by environmental risk scores (ERS), a summation of total exposures, to evaluate the association with risk (ERSrisk) and survival (ERSsurvival). Results Samples from 164 ALS and 105 control participants were analysed. Several individual POPs significantly associated with ALS, including 8
Source: jnnp.bmj.comCategories: General Medicine News, General NewsTweet
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Mashup Score: 0Incorporating Genetic Testing Into the Care of Patients With Amyotrophic Lateral Sclerosis/Frontotemporal Degeneration Spectrum Disorders - 7 month(s) ago
Purpose of Review Amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) spectrum disorders have a strong genetic component. Genetic counselors are a limited resource, and therefore, other providers must be prepared to integrate genetic testing into their practice. Recent Findings Recent ALS/FTD studies have demonstrated that lack of family history does not preclude a genetic etiology. The benefits of a genetic diagnosis have expanded to include the potential to treat; thus, genetic testing is increasingly recommended to be offered to all persons with ALS/FTD. Summary Offering genetic testing to persons with ALS/FTD spectrum disorders should be part of routine clinical neurologic care. All genetic testing should include discussion about the medical and psychosocial implications of testing for the patient and family members. Neurologists should be prepared to facilitate this process and recognize when referral to a genetic counselor is indicated.
Source: cp.neurology.orgCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 3European regulators consider appeal over Amylyx ALS drug - 7 month(s) ago
This week, European regulators are considering an appeal from Amylyx Pharmaceuticals after initially recommending against approving the company’s ALS treatment.
Source: www.statnews.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0
Nuro announced that a teenager with amyotrophic lateral sclerosis (ALS) regained some communication ability with its technology.
Source: www.massdevice.comCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 2
A panel of independent advisers to the FDA voted against a polarizing potential treatment for ALS on Wednesday, concluding that the medicine’s supporting data did not meet the standard for approval.
Source: www.statnews.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1FDA Panel Overwhelmingly Rejects ALS Cell Therapy - 8 month(s) ago
Echoing concerns from agency reviewers, advisors can’t find evidence of efficacy
Source: www.medpagetoday.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0Patient Story - 8 month(s) ago
In the fall of 2004, while at work Urbiha experienced some health symptoms affecting her left hand and arm that she initially thought might be part of the aging process.
Source: www.henryford.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0
Agency scientists flagged numerous issues with Brainstorm’s stem cell treatment ahead of a high-profile Wednesday meeting of expert FDA advisers.
Source: www.healthcaredive.comCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 4Incorporating Genetic Testing Into the Care of Patients With Amyotrophic Lateral Sclerosis/Frontotemporal Degeneration Spectrum Disorders - 8 month(s) ago
Purpose of Review Amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) spectrum disorders have a strong genetic component. Genetic counselors are a limited resource, and therefore, other providers must be prepared to integrate genetic testing into their practice. Recent Findings Recent ALS/FTD studies have demonstrated that lack of family history does not preclude a genetic etiology. The benefits of a genetic diagnosis have expanded to include the potential to treat; thus, genetic testing is increasingly recommended to be offered to all persons with ALS/FTD. Summary Offering genetic testing to persons with ALS/FTD spectrum disorders should be part of routine clinical neurologic care. All genetic testing should include discussion about the medical and psychosocial implications of testing for the patient and family members. Neurologists should be prepared to facilitate this process and recognize when referral to a genetic counselor is indicated.
Source: cp.neurology.orgCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 2Pharmalittle: FDA to furlough one-fifth of staff if government shuts down; FDA cites 'grossly deficient' data for ALS drug - 8 month(s) ago
If U.S. lawmakers are unable to prevent a government shutdown by Oct. 1, the FDA will have to furlough almost one-fifth of its staff.
Source: www.statnews.comCategories: General Medicine News, Latest HeadlinesTweet
Drawing a tube of blood could assess #ALS risk from environmental toxin exposure @umich https://t.co/Eu6ZDnFSuo https://t.co/nCDSNVkdT9