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Mashup Score: 1
Hereditary alpha-tryptasemia (HαT) is an autosomal dominant genetic trait found in 4% to 6% of the general population and defined by excess copies of alpha-tryptase at TPSAB1. Elevated basal serum tryptase (sBT >8 ng/mL) is a defining feature of HαT and appears to result from increased pro-alpha-tryptase synthesis and secretion rather than mast cell activation. It is estimated that approximately…
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Mashup Score: 1Prevalence of alpha-gal sensitization among Kentucky timber harvesters and forestry and wildlife practitioners - 3 year(s) ago
It has been discovered that people develop an allergy to an oligosaccharide galactose-α-1,3-galactose, also called alpha-gal, after experiencing tick bites.1-3 Allergic reactions typically occur after eating meat from mammals that contain alpha-gal or are exposed to products made from mammals.3,4 An association between tick bites and this allergy has been described in studies that detected serum…
Categories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 0
Hereditary alpha-tryptasemia (HαT) is an autosomal dominant genetic trait found in 4-6% of the general population and defined by excess copies of alpha-tryptase at TPSAB1. Elevated basal serum tryptase (sBT > 8 ng/mL) is a defining feature of HαT and appears to result from increased pro-alpha-tryptase synthesis and secretion rather than mast cell activation. It is estimated that approximately one…
Categories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 1Prevalence of alpha-gal sensitization among Kentucky timber harvesters and forestry and wildlife practitioners - 3 year(s) ago
It has been discovered that people develop an allergy to an oligosaccharide galactose-α-1,3-galactose, also called alpha-gal, after experiencing tick bites.1-3 Allergic reactions typically occur after eating meat from mammals that contain alpha-gal or are exposed to products made from mammals.3,4 An association between tick bites and this allergy has been described in studies that detected serum…
Categories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 1
Hereditary alpha-tryptasemia (HAT) is a genetic trait caused by an increased alpha-tryptase tryptase alpha/beta 1 gene copy number. Basal serum mast cell tryptase (MCT) level is typically greater than or equal to 8.0 ng/mL.
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Mashup Score: 2Platelet-derived growth factor receptor-alpha-positive myeloid neoplasm presenting as eosinophilic gastrointestinal disease - 4 year(s) ago
Eosinophilic gastrointestinal diseases (EGIDs) are single-organ hypereosinophilic syndromes (HESs) characterized by eosinophilic inflammation involving any segment of the gastrointestinal (GI) tract and include eosinophilic esophagitis , eosinophilic gastritis, eosinophilic gastroenteritis, and eosinophilic colitis. Peripheral eosinophilia (≥500/mm3) is common in patients with EGID, and some…
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Mashup Score: 5
Hereditary Alpha-Tryptasemia (HAT) is a genetic trait caused by an increased alpha-tryptase TPSAB1 gene copy number. Basal serum mast cell tryptase is typically ≥8.0ng/ml.
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Mashup Score: 1Usefulness of testing for hereditary alpha tryptasemia in symptomatic patients with elevated tryptase - 4 year(s) ago
Alpha- and beta-tryptases are mast cell–derived serine proteases encoded by the genes TPSB2 and TPSAB1.1,2 Basal serum tryptase (BST) is elevated in 4% to 6% of Western populations.3 Rarely, this is caused by systemic mastocytosis (SM), and more commonly, by hereditary alpha tryptasemia (HαT), an autosomal dominant trait resulting from increased TPSAB1 copy number encoding alpha-tryptase. SM and…
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Mashup Score: 2A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation | Circulation Research - 4 year(s) ago
Rationale: The heart undergoes dramatic developmental changes during the prenatal to postnatal transition, including maturation of cardiac myocyte energy metabolic and contractile machinery. Deline…
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Tolerance of porcine pancreatic enzymes despite positive skin testing in alpha-gal allergy - 4 year(s) ago
In endemic areas around the world, galactose-alpha-1,3-galactose (alpha-gal) sensitivity has emerged as an etiology of mammalian meat allergy that is causally associated with bites from sensitizing ticks.1 Alpha-gal syndrome (AGS) typically presents with delayed anaphylaxis after consumption of mammalian meat, and less commonly with similar reactions to mammalian milks and gelatin.1…
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In Current Issue! The #Genetic #Basis and Clinical Impact of #Hereditary #Alpha- #Tryptasemia https://t.co/JI7sdGIv0r https://t.co/XU97nWHAnG