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    The GioTag study assessed how drugs called afatinib and osimertinib affected people with non-small cell lung cancer (NSCLC) who had mutations in the epidermal growth factor receptor (EGFR) gene. Resistance mutations in our genes can lead to resistance to specific treatments, meaning that drugs no longer work. Patients in the current study all initially received afatinib treatment before they…

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    • Find out about the GioTag study, exploring sequential #Afatinib + #Osimertinib in #EGFR #NSCLC , in this #PLSP from @FutureOncol_FSG https://t.co/WceovZTUZW https://t.co/rv30fcjHun

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    The GioTag study assessed how drugs called afatinib and osimertinib affected people with non-small cell lung cancer (NSCLC) who had mutations in the epidermal growth factor receptor (EGFR) gene. Resistance mutations in our genes can lead to resistance to specific treatments, meaning that drugs no longer work. Patients in the current study all initially received afatinib treatment before they…

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    • Don't miss out on reading this Plain Language Summary of the #GioTag study on sequential #Afatinib + #Osimertinib in #EGFR #NSCLC https://t.co/wrhvmmxRzc #LCAM #lcsm #lungcancerawarenessmonth https://t.co/LWRx1ywuLA

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    Current clinical trials of combined EGFR-tyrosine kinase inhibitors (TKI) and immune checkpoint blockade (ICB) therapies show no additional effect. This raises questions regarding whether EGFR-TKIs attenuate ICB-enhanced CD8+ T lymphocyte function. Here we show that the EGFR-TKI afatinib suppresses CD8+ T lymphocyte proliferation, and we identify CAD, a key enzyme of de novo pyrimidine…

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    • Study by Tu et al reveals EGFR tyrosine kinase inhibitor #afatinib has immunomodulatory effects on CD8+ T lymphocytes which may help guide treatment timing for combined targeted therapy and #immunotherapy. https://t.co/iUWjnoutF0 https://t.co/GhtieSK6rO

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    At Oncology Central we are dedicated to advancing oncology by publishing trusted, engaging and insightful resources for the global oncology community.

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    • Discover more about the use of #Afatinib for the treatment of #NSCLC #LungCancer harboring uncommon EGFR mutations in the latest @VJofBiomedicine Publication Perspective: https://t.co/SwcjKcSkbY