Nature – Cryo-electron microscopy structures of apolipoprotein B100 (apoB100) in complex with the LDL receptor (LDLR) provide insight into binding interfaces and explain how mutations in apoB100 or…
Imlunestrant is a next-generation, brain-penetrant, oral selective estrogen-receptor (ER) degrader that delivers continuous ER inhibition, even in cancers with mutations in the gene encoding ERα…
As health insurers use AI to deny more claims, startups are turning to AI to make it easier to appeal denials, which often go uncontested.
Objectives This study aimed to explore the prevalence of medication non-adherence and influence of symptom perception and various barriers on medication adherence among Thai Muslim…
Doctors from Syria who work for the NHS have told The BMJ about “Holocaust-like” scenes that have unfolded at the liberated Saydnaya military prison 18…
Nature Neuroscience – Reward signaling via dopamine is most commonly thought of as acting through neurons expressing either D1 or D2 dopamine receptors. Enriquez-Traba et…
Nature Neuroscience – Ventral striatal dopamine D3 and D1 receptors regulate motivation and reinforcement, respectively, through dissociable physiological actions.
Falnikar et al. report that the nucleoporin Nup153, a binding partner of microtubule motor protein Kif1a, originally identified in a proteomic study, recruits Kif1a to the…
Background Sleep is essential for the recovery of patients with disorders of consciousness (DoC). However, few approaches targeting sleep were applied. Melatonin has been shown…
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This review focuses on DRESS, a serious drug-induced T-cell–mediated condition with marked cutaneous and systemic effects.
