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Mashup Score: 18Characterizing the Racial Discrepancy in Hypoxemia Detection in VV-ECMO: An ELSO Registry Analysis - 6 month(s) ago
Importance: Skin pigmentation influences peripheral oxygen saturation (SpO2) measured by pulse oximetry compared to the arterial saturation of oxygen (SaO2) measured via arterial blood gas analysis. However, data on SpO2-SaO2 discrepancy are …
Source: www.researchsquare.comCategories: General Medicine News, Critical CareTweet
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Mashup Score: 0Home - 6 month(s) ago
Research Square is a preprint platform that makes research communication faster, fairer, and more useful.
Source: www.researchsquare.comCategories: General Medicine News, CardiologistsTweet-
Have you ever conducted peer reviews for Research Square? If you ever reviewed for them, do you find their payments ($50 per review completed in a few days) appropriate? https://t.co/L9HVac57am @researchsquare
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Mashup Score: 2Phase I Trial Evaluating Locoregionally-delivered IL13Rα2-targeting CAR T Cells in High-Grade Glioma - 6 month(s) ago
Chimeric antigen receptor (CAR) T cell therapy is at early stages of clinical testing for solid tumors. We report here a completed phase I trial (NCT02208362) evaluating locoregional delivery of IL13Rα2-targeted CAR T cells in 65 patients with recurrent high-grade glioma, the majority being re…
Source: www.researchsquare.comCategories: General Medicine News, Hem/OncsTweet-
As a quick side bar, this CAR and the intraventricular approach were first deployed in an adult trial led by Christine Brown which you can check out here: https://t.co/MCFYT1BNyN. A lot of learnings from the adult trail were applied to what has been done in the pediatric trial.
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Mashup Score: 17Human milk affects TLR4 activation and LPS-induced cytokine expression in Caco-2 intestinal epithelial cells - 7 month(s) ago
Background: Human milk (HM) components affect immune cell toll-like receptor 4 (TLR4) signaling. However, studies examining the immunomodulatory impacts of HM on TLR4 signaling in intestinal epithelial cells (IECs) are limited. Methods: This study utili…
Source: www.researchsquare.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Exciting research on the role of human milk by our very own @crpizzarello. See #preprint on @researchsquare: Human milk affects TLR4 activation and LPS-induced cytokine expression in Caco-2 intestinal epithelial cells https://t.co/aag2di2z52
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Mashup Score: 2Quantitative errors in the Cochrane review on "Physical interventions to interrupt or reduce the spread of respiratory viruses" - 7 month(s) ago
The COVID-19 pandemic has brought a heightened sense of urgency in the scientific community regarding the need to advance understanding and prevention of pathogen transmission, particularly concerning infectious airborne particles and the utility of various preventive strategies in reducing the r…
Source: www.researchsquare.comCategories: General Medicine News, Hem/OncsTweet-
Quantitative errors in the @cochranecollab review on "Physical interventions to interrupt or reduce the spread of respiratory viruses" https://t.co/PtzHkJckgX via @nntaleb et al https://t.co/nsAVTxFp7L
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Mashup Score: 10A Lifestyle Modification Program for Secondary Prevention of Atrial Fibrillation: A Pilot Study - 7 month(s) ago
Background Lifestyle modification programs, such as cardiac rehabilitation, may reduce atrial fibrillation (AF) burden and improve quality of life (QOL), but remain unproven. The objective of this pilot study was to assess feasibility, acceptability, and preliminary effectiveness of a…
Source: www.researchsquare.comCategories: Cardiologists, Latest HeadlinesTweet-
Obesity is a potentially causal risk factor for atrial fibrillation. @JeffAshburner describes our new lifestyle modification program @MGHHeartHealth for overweight pts w symptomatic AF. After 12w in single arm, wt ↓ & AF burden/Sx also ↓ https://t.co/rFGQtZNbQC @researchsquare https://t.co/OAlzX6wBGK
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Mashup Score: 1Knowledge, attitudes and practices about research misconduct among medical residents in Southwest China: a cross-sectional study - 7 month(s) ago
Background With the emergence of numerous scientific outputs, growing attention are paid to research misconduct. This study aimed to investigate knowledge, attitudes and practices about research misconduct among medical residents in Southwest China.Methods A cross-sect…
Source: www.researchsquare.comCategories: Cardiologists, Latest HeadlinesTweet-
This study shew a high self-reported rate of research misconduct among residents, and research misconduct knowledge and perceived consequences for research misconduct were necessary to be improved https://t.co/gonzJ2Xvd5
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Mashup Score: 23
RAS oncogenes (collectively NRAS, HRAS, and especially KRAS) are among the most frequently mutated genes in cancer, with common driver mutations occurring at codons 12, 13 and 611. Small molecule inhibitors of the KRASG12C oncoprotein have demon…
Source: www.researchsquare.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RMC-6236 is a RASMULTI(ON) inhibitor from Revolution Medicines currently in clinical trials in KRAS-mutated solid cancers. RevMed has recently posted the preprint of the related preclinical compound RMC-7977: https://t.co/xUMOwqCxrV - RMC-7977 demonstrated potent preclinical… https://t.co/LYAIVqMVbP https://t.co/QfQW6Xy6xk
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Mashup Score: 3Fluvoxamine restores TFEB-mediated autophagy through Sigma-1R-controlled POM121 expression - 11 month(s) ago
Expansion of the GGGGCC-RNA repeat is a known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two conditions that currently have no cure. Recent studies have shown that activation of the Sigma-1 receptor plays an important role in providing neuroprotection, part…
Source: www.researchsquare.comCategories: Latest Headlines, Rare DiseaseTweet-
RT @Rothstein_Lab: Fluvoxamine restores TFEB-mediated autophagy through Sigma-1R-controlled POM121 expression https://t.co/ClloJcSh50
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Mashup Score: 3The bat-borne influenza A virus H9N2 exhibits a set of unexpected pre-pandemic features - 12 month(s) ago
An Old-World bat H9N2 influenza A virus (IAV) identified in Egypt exhibits high replication and transmission potential in ferrets, efficient infection of human lung explant cultures and marked escape from the antiviral activity of MxA. Together with low antigenic similarity to N2 of seasonal huma…
Source: www.researchsquare.comCategories: Infectious Disease, Latest HeadlinesTweet-
Excited to see this work out as a preprint - heard about it a while ago, another surprising virus finding from bats and frankly a bit worrying too. The bat-borne influenza A virus H9N2 exhibits a set of unexpected pre-pandemic features https://t.co/tAFaKNatWQ
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⚖️ Racial discrepancy in detecting hypoxemia in VV #ECMO, ELSO Registry analysis demonstrating that Hispanic & Black pts experienced occult hypoxemia more than White pts. ⚠️Carefully monitor SaO2 during #ECLS, especially if high EBF & lactates #FOAMcc 🔓 https://t.co/2uuEo3cMZS https://t.co/r7th5Uq6C3