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    Osteoarthritis (OA) pain involves peripheral and central neural pathways, as well as interactions between multiple cell types and soluble mediators.1 Although therapeutic targeting of peripheral OA pain pathways might prove simpler and be associated with fewer side effects, the complexity of OA pain means that it will likely be the case that what works for one patient will be inefficacious for another. Consequently, it is important to further our understanding of OA pain mechanisms to develop new treatments and thus expand the clinician’s therapeutic arsenal.

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    The ‘Emperor’s New Clothes’ is a classic Danish tale written by Hans Christian Andersen. The story has been translated into over 100 languages. In brief, the plot is about a vain Emperor who loves spending the state’s money on expensive clothing. A couple of swindlers posing as weavers are offering the Emperor clothes made of the most delicate fabric that is said to be visible only to those who are fit for their office and not incompetent. The Emperor hires the swindlers, who set up their looms and pretend to weave.

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    • RT @rheum_cat: Comment in @OACJournal - exercise in OA as a retelling of the fable, The Emperor's New Clothes? https://t.co/CQ1CUYzpw5 ht…

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    EDITORIALRecreational running is not bad for healthy people’s joints — it is time to study the safety of running in people with osteoarthritisJ.-F. Esculier,C. BartonPublished online: November 15, 2022p135-137Full-Text HTMLPDF COMMENTARIESAll that glistens is not goldP. Richette,A. LatourtePublished online: October 25, 2022p138-139Full-Text HTMLPDF Evidence…

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    • Our #EditorsChoice papers chosen by @ProfDavidHunter and @AM_Malf are free to read during the month of February 🤩 📖 Check out these papers and the full issue at https://t.co/oXOio2VgZL @Baumbach_Linda https://t.co/EJyBVO9RB0

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    Acknowledgement to Reviewers 2022D. Hunter,A.-M. MalfaitPublished online: November 24, 2022p1-5Full-Text HTMLPDF EDITORIALSDisentangling the molecular interplays between subchondral bone and articular cartilage in estrogen deficiency-induced osteoarthritisSantos Castañeda,Esther F. Vicente-RabanedaPublished online: September 27, 2022p6-8Full-Text HTMLPDF …

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    • The January issue of OAC is now online! 🦴 Osteoarthritis bone marrow lesions 🔬 Changes of the subchondral bone microchannel network in early #osteoarthritis 🦵🏻 Patellofemoral contact forces and knee gait mechanics following ACL reconstruction ➡️https://t.co/s2Q46E4zf6 https://t.co/poohU8avSg

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    EDITORIALWaiting for orthopedic surgery — are we underestimating the impacts on people with advanced osteoarthritis?I.N. AckermanPublished online: September 02, 2022p1545-1546Full-Text HTMLPDF FUNDAMENTALS OF OACellular therapy and tissue engineering for cartilage repairA. Zelinka,A.J. Roelofs,R.A. Kandel,C. De BariPublished online: September 19, 2022p1547-1560Open AccessFull-Text…

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    • Read the #EditorsChoice papers chosen by @ProfDavidHunter and @AM_Malf for free in the Dec issue ⏰ Impact of waiting time for ortho consults on pain levels @rhiannon_patten 🐁 Subchondral bone structure + synovial fluid metabolism in mice @hislop_brady https://t.co/TqvW5QXAv1 https://t.co/IyAmFJTAqK

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    EDITORIALSCausal inference from observational data and target trial emulationS.R. Jafarzadeh,T. NeogiPublished online: September 01, 2022p1415-1417Full-Text HTMLPDF Metformin as a potential disease-modifying agent in osteoarthritis: the present and the futureR.W.S. SitPublished online: August 24, 2022p1418-1419Full-Text HTMLPDF REVIEWSSystematic ReviewsDoes…

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    • The November issue of OAC is now online! This month's #EditorsChoice papers are: 🦴 A prospective study using [18F]sodium fluoride PET-MRI to detect bone changes 🧬 Phosphoproteonomics reveals BRAF-ERK1/2 as potential signaling pathway in OA https://t.co/TqvW5QXAv1 https://t.co/T5wUq5jHpY

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    REVIEWSNarrative reviewThe relationship between meniscal pathologies, cartilage loss, joint replacement and pain in knee osteoarthritis: a systematic reviewA. Ghouri,S. Muzumdar,A.J. Barr,…C. Murdoch,S.R. Kingsbury,P.G. ConaghanPublished online: August 10, 2022p1287-1327Open AccessFull-Text HTMLPDF Supplemental MaterialsORIGINAL PAPERSBasic and translational researchBiglycan…

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    • 🚨The October issue of OAC is now online 🚨 This month's #EditorsChoice papers are: 💊 Time trends in NSAID and opioid use following total hip replacement 🐭 Time course and localization of NGF expression during knee #osteoarthritis in rats Read➡️ https://t.co/TqvW5Rfbmz https://t.co/F80JpCF5YI

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    EDITORIALSEditorial for ‘Quantitative T2 and T1ρ mapping are sensitive to ischemic injury to the epiphyseal cartilage in an in vivo piglet model of Legg-Calvé-Perthes disease’A.F. Lombardi,E.Y. Chang,J. DuPublished online: July 05, 2022p1155-1156Full-Text HTMLPDF As the prevalence of obesity increases, rationing arthritis care is not the answerA. Brown,B. RaviPublished online:…

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    • Our #EditorsChoice papers chosen by @ProfDavidHunter and @AM_Malf are free to read, but only for the month of September! ⭐️ Check them out in the current issue⤵️ https://t.co/s2Q46E574E https://t.co/hEC3xLNy6P