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Mashup Score: 9
Anterior cruciate ligament (ACL) injuries are a major problem in the pediatric and adolescent populations. Some of these injuries are only partial; yet, there is limited data to inform clinical treatment of such partial tears. It is unknown how injury partial injury impacts long-term degenerative changes in the joint relative to complete injury. In this study, we hypothesized that partial (anteromedial (AM) or posterolateral (PL) bundle) tears would result in small levels of instability and degeneration relative to complete ACL tears and that the degree of degeneration would associate with joint instability.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 11A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine - 1 month(s) ago
Investigational cell therapies have been developed as disease-modifying agents for the treatment of osteoarthritis (OA), including those that inducibly respond to inflammatory factors driving OA progression. However, dysregulated inflammatory cascades do not specifically signify the presence of OA. Here, we deploy a synthetic receptor platform that regulates cell behaviors in an arthritis-specific fashion to confine transgene expression to sites of cartilage degeneration.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
The #BasicScience #EditorsChoice for #February is this cutting edge work from @jbrunger's lab! Read about how @bonlwalton deployed a synthetic receptor platform that regulates cell behaviors here: https://t.co/KUHeyxo4Pr https://t.co/DLqSeFkibi
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Mashup Score: 14Assessment of whole cartilage surface damage in an osteoarthritis rat model: The Cartilage Roughness Score (CRS) utilizing microcomputed tomography - 1 month(s) ago
This study aims to establish an accurate and robust imaging biomarker for pre-clinical osteoarthritis (OA) research, focusing on early detection of cartilage surface degeneration.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
Check this out ➡️ This study by Kauppinen et al. aims to establish an accurate and robust imaging biomarker for pre-clinical OA research, focusing on early detection of cartilage surface degeneration. Learn more 🔗 https://t.co/kpuYsMnISL https://t.co/nY3KsWJnl6
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Mashup Score: 2H3K9me3 loss and ERVs activation as hallmarks for osteoarthritis progression and knee joint aging - 1 month(s) ago
This study aims to link aberrant endogenous retroviruses (ERVs) activation and osteoarthritis (OA) progression by comparing the chromatin accessibility and transcriptomic landscapes of diseased or intact joint tissues of OA patients.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
The loss of a chromatin silencing marker, H3K9me3, is associated with joint aging and OA progression. H3K9me3 loss causes chromatin relaxation, the activation of endogenous retroviruses (ERVs) and increased inflammatory signaling @V_Molchanov1 Learn more: https://t.co/5NPIWNSZTy https://t.co/AaxDAX8dvf
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Mashup Score: 12
Proteolytic cartilage extracellular matrix breakdown is a major mechanism of articular cartilage loss in osteoarthritis (OA) pathogenesis. We sought to determine the overlap of proteolytic peptides in matched knee OA cartilage and synovial fluid on a proteome-wide scale to increase the prospective biomarker repertoire and to attribute proteolytic cleavages to specific secreted proteases.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
More #BasicScience in #OAC in this work, Bhutada et al. determines the overlap of proteolytic peptides in matched knee OA cartilage and synovial fluid on a proteome-wide scale to increase the prospective biomarker repertoire.🧪 🥼 Read more 📑 https://t.co/BspuPUFXsq https://t.co/WCJwX8lJJd
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Mashup Score: 1Zoledronate alleviates subchondral bone collapse and articular cartilage degeneration in a rat model of rotator cuff tear arthropathy - 2 month(s) ago
To evaluate the humeral head bone volume of patients with cuff tear arthropathy (CTA) and examine the therapeutic effect of zoledronate in a rat modified model of CTA (mCTA).
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
New #BasicScience in #OAC this work by Tawaratsumida et al. evaluates the humeral head bone volume of patients with cuff tear arthropathy (CTA) and examines the therapeutic effect of zoledronate in a rat modified model of CTA (mCTA). Read more 📖 https://t.co/R9Sqdxt7pY https://t.co/sgmvJN5bg7
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Mashup Score: 8
To assess the longitudinal stability of biomarker-based molecular endotypes of knee osteoarthritis (KOA) participants from APPROACH and to evaluate the consistency of findings in an independent KOA population.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
Interested in why these @monicahannani et al. support the use of #biomarkerbased endotyping in #DMOADs #clinicaltrials? Read (free!) in this month's @OACJournal - https://t.co/tz3RJidUVJ @Nordic_Bio @uni_copenhagen https://t.co/OyKuuXhRL4
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Mashup Score: 3A major functional role of synovial fluid is to reduce the rate of cartilage fatigue failure under cyclical compressive loading - 2 month(s) ago
Based on our recent study, which showed that cartilage fatigue failure in reciprocating sliding contact results from cyclical compressive forces, not from cyclical frictional forces, we hypothesize that a major functional role for synovial fluid (SF) is to reduce the rate of articular cartilage fatigue failure from cyclical compressive loading.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
And the first #EditorsChoice #BasicScience of 2025 is this work by Sise et al. Read more about the lubricating role of synovial fluid on cartilage! 🎇 Read more 📑https://t.co/F5b9q8F8A3 https://t.co/EUrlL8oujX
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Mashup Score: 0
Distal radius fractures (DRFs) with dorsal malunion increase the risk of osteoarthritis (OA), although the cause of post-DRF OA is yet to be elucidated. To clarify the abnormal effects of a post-DRF dorsal radius deformity, we evaluated the bone density (BD) and stress-distribution patterns of the articular surface in dorsally malunited DRFs.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
What is the association of dorsal malunion in #distalradius fractures with wrist #osteoarthritis? Read about this and more from Kazui et al. in this month's @OACJournal issue! https://t.co/k8oaQoCXN3 https://t.co/uiyEaFKok4
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Mashup Score: 25When ‘synovitis’ is not synovitis - 2 month(s) ago
Although osteoarthritis (OA) is still clinically referred to as a ‘noninflammatory’ arthritis, because physical signs of overt inflammation at the patient level are often absent or mild, both cellular and molecular inflammation are widely recognized to be active components of OA pathogenesis. Moreover, osteoarthritic processes have been proposed to be conceptually similar to those in a chronic wound, whereby constant stimulation of innate inflammatory pathways by tissue damage leads to a chronic remodeling response by the entire synovial joint organ.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
New in this month's @OACJournal 🤔 When ‘synovitis’ is not synovitis @carla_scanzello @ScanzelloLab @SungYeon___Kim encouraging researchers to "consider the complexity of the #synovial response, and the aspects of damage and inflammation separately" - https://t.co/uDbqbkxMXO https://t.co/zjsTrB9AhC
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New this month 🤩 Children vs adults - are the effects of #ACL injuries the same? This study by Howe et al. found the presence of early degenerative differences in immature porcine models that might lead to joint instability Read more: https://t.co/BEIByYbma7 https://t.co/BYMR0NqbEE