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Mashup Score: 5
To evaluate the efficacy and safety of intra-articular injections of a novel aggrecan mimetic, SB-061, in subjects with knee osteoarthritis (OA).
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 16
To monitor serum concentrations of the aggrecan alanine-arginine-glycine-serine (ARGS) neoepitope in a clinical trial of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5 inhibition as disease-modifying therapy of knee osteoarthritis, and to investigate relationships between reduction in ARGS and change in cartilage thickness, knee-related pain and function.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
🆕 NOV's #editorschoice is from @lunduniversity What are the effects of systemic inhibition of ADAMTS-5 in knee #osteoarthritis? Read more from the #ROCCELLA trial and Larsson et al. as they investigate further - https://t.co/jKNUVg0uQM https://t.co/8YSBdWPy87
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Mashup Score: 7IL-23p19 in osteoarthritic pain and disease - 6 day(s) ago
We have previously reported that the interleukin-23 p19 subunit (IL-23p19) is required for experimental inflammatory arthritic pain-like behavior and disease. Even though inflammation is often a characteristic feature of osteoarthritis (OA), IL-23 is not usually considered as a therapeutic target in OA. We began to explore the role of IL-23p19 in OA pain and disease utilizing mouse models of OA and patient samples.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
🌟Our #BasicScience #EditorsChoice for November is this brief report from Lee et al. 🌟 Great work to all authors: @TLupancu @AdrianAchuthan Access this work: https://t.co/sUXh1L50H9 https://t.co/QLJGb2Eako
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Mashup Score: 13
To assess whether patient reported outcome measures (PROMs) improve after autologous conditioned serum (ACS) administration in patients with osteoarthritis.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
🌶️ in this month's @OACJournal "There is currently insufficient data to support the use of autologous conditioned serum injections in #osteoarthritis" Read for free from Curtis et al @BristolBRC - https://t.co/1vnT1hl2ws https://t.co/9JSIaD7KrK
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Mashup Score: 7
We here explore whether observed treatment effects of a putative disease-modifying osteoarthritis drug (DMOAD) are greater when cartilage morphometry is performed with rather than without knowledge of magnetic resonance imaging (MRI) acquisition order (unblinded/blinded to time point).
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
Are #DMOAD treatment effects greater when MRIs are read unblinded to order? #kneeosteoarthritis Read more in this month's @OACJournal issue from Eckstein at al. here - https://t.co/g1oCbnexah https://t.co/dBsOWJtdzS
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Mashup Score: 14
To investigate relationships between static foot posture, dynamic plantar foot forces and knee pain in people with medial knee osteoarthritis (OA).
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
NEW this month @OACJournal ✅ Higher plantar foot forces when walking 🚶♂️ seen in those with knee #osteoarthritis Read more from @KadePaterson @KimBennell @AnurikaDeSilva @HinmanRana @CHESM_unimelb @UniMelbMDHS at https://t.co/dvqy2nQ9R3 https://t.co/9Wp1FXkEop
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Mashup Score: 3Effect of isometric quadriceps exercise on local microcirculation of the infrapatellar fat pad in female patients with knee osteoarthritis - 29 day(s) ago
To elucidate the local microcirculation of the infrapatellar fat pad (IFP) in patients with knee osteoarthritis (KOA) by determining the changes in IFP hardness and hemoglobin concentration during isometric quadriceps exercise (IQE).
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
⚡️ Just published!⚡️ Local #fatpad #microcirculation may be impaired in those with knee #OA due to a lack of mechanical stress Read more from authors Nakanishi et al @Takapon_PT_PhD @morinomiya_univ at https://t.co/cs1tadd7fb https://t.co/pxefHcFDvJ
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Mashup Score: 8
It has been recognized that imaging findings associated with osteoarthritis (OA) are common in asymptomatic healthy joints, including the knee,1 hip2 and spine3,4 as shown in Figure 1. These incidental imaging findings, if not interpreted in the appropriate clinical context, may result in unnecessary and possibly harmful additional imaging tests and treatments.5 In addition, when an osteoarthritic joint is symptomatic, the extent of radiographic markers of osteoarthritis does not always correlate well with the severity of patient symptoms.
Source: www.oarsijournal.comCategories: General Medicine News, Hem/OncsTweet-
Prevalence of OA-related imaging abnormalities in asymptomatic healthy adults https://t.co/9ncg8FsBHL via @JimLink65 et al Another good editorial for @rcgp #Overdiagnosis Group @DrDavidSpitzer @mgtmccartney https://t.co/BeOixAuPOi
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Mashup Score: 1Stem cell injections for knee osteoarthritis: Time for a reality check and some strategic thinking - 1 month(s) ago
Every reader of this journal knows that novel therapies for osteoarthritis (OA) are sorely needed. Many of us have spent decades doing rigorous trials of new therapies and have had many more failures than successes. Thus, myself and many others were excited by the 2003 initial report in a young goat model with post traumatic OA suggesting mesenchymal stem cells injected into the knee appeared to have both symptom and structure modifying properties.1 There were a number of obvious questions in translating this result to humans.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
⚠️ In this month's @OACJournal "Stem cell injections for knee #osteoarthritis: Time for a reality check and some strategic thinking" Graeme Jones @ResearchMenzies https://t.co/mKySpS0skU
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Mashup Score: 9
Osteoarthritis is a common and complex joint disorder that shows higher prevalence and greater disease severity in women. Here, we investigate genome-wide methylation profiles of primary chondrocytes from osteoarthritis patients.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
Last up for our #September #OAC #SpecialEdition This study by Krietmaier et al. provides the largest genome-wide #methylation profiles of primary #cartilage with sex-specific insights into epigenetic processes underlying #OA progression. @EleZeggini 🔗 https://t.co/XdqlqFvpKD https://t.co/UZs6aNgt2A
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NEW @OACJournal 📢 Do intra-articular injections with SB-061 (aggrecan mimetic) improve structural changes in knee #OA? That and more by Bihlet et al. in https://t.co/am6XFizhOo https://t.co/fe5DILiVxM