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Mashup Score: 8Short-term outcomes after third-time lung transplantation: A single institution experience - 1 day(s) ago
Reoperative lung transplantation (LTx) survival has improved over time such that a growing number of patients may present for third-time LTx (L3Tx). To understand the safety of L3Tx, we evaluated perioperative outcomes and 3-year survival after L3Tx at a high-volume US LTx center.
Source: www.jhltonline.orgCategories: General Medicine News, Cardiology News and JournTweet
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Mashup Score: 8Recurrent Pulmonary Hypertension After Balloon Pulmonary Angioplasty for Inoperable Chronic Thromboembolic Pulmonary Hypertension - 2 day(s) ago
Balloon pulmonary angioplasty improves the hemodynamics of patients with inoperable chronic thromboembolic pulmonary hypertension; however, the clinical impact of recurrent pulmonary hypertension after balloon pulmonary angioplasty remains unclear.
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Mashup Score: 16
To date, no pediatric studies have highlighted the impact of center’s ventricular assist device (VAD) volumes on post implant outcomes.
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Mashup Score: 12
Cardiac metabolism is altered in heart failure and ischemia-reperfusion injury states. We hypothesized that metabolomic profiling during ex situ normothermic perfusion before heart transplantation (HT) would lend insight into myocardial substrate utilization and report on subclinical and clinical allograft dysfunction risk.
Source: www.jhltonline.orgCategories: General Medicine News, Cardiology News and JournTweet-
Metabolomic Profiling During Ex-situ Normothermic Perfusion Prior to Heart Transplantation Defines Patterns of Substrate Utilization & Correlates w Markers of Allograft Injury @laurentrubymd @_adevore @jacobniall @SvatiShah cc @ahajduczok @rachkataria đź”—: https://t.co/7jCkMAQpbf https://t.co/nOGrC0HVf4
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Mashup Score: 1
Adult T-cell leukemia/lymphoma (ATLL) is a rare disease caused by the human T-lymphotropic virus (HTLV). Only 4% of patients infected with HTLV contract ATLL, and most take decades to present with malignancy. Herein, we present a rare case of ATLL following a heart transplantation.
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Acute T cell leukemia in a stable recipient of a heart transplantation. The authors recommend preop survey & regular monitoring of HTLV-1/2 carrier recipients after ❤️tx, given lack of established chemotherapy/antivrial agents for such patients. 🔗 https://t.co/vgbqZ90yrZ https://t.co/bBIhj1JAMH
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Mashup Score: 2
To verify whether the new hemodynamic definition of pulmonary hypertension (PH) has any implication in treatment of Chronic Thrombo-Embolic Pulmonary Disease (CTEPD) patients without PH, we retrospectively analysed the clinical and functional changes determined by pulmonary endarterectomy (PEA) in 63 CTEPD patients without PH who underwent surgery at our center, comparing those in whom the hemodynamic diagnosis of PH met recent guideline recommendations versus those in whom the diagnosis only met previous hemodynamic thresholds.
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Mashup Score: 6Recipient Outcomes with Extended Criteria Donors Using Advanced Heart Preservation: An Analysis of the GUARDIAN Heart Registry - 13 day(s) ago
The prevalence of end stage heart failure and patients that could benefit from heart transplantation requires an expansion of the donor pool, relying on the transplant community to continually re-evaluate and expand the use of extended criteria donor organs. Introduction of new technologies such as the Paragonix SherpaPak Cardiac Transport System aids in this shift. We seek to analyze the impact of the SherpaPak system on recipient outcomes who receive extended criteria organs in the GUARDIAN Heart Registry.
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Mashup Score: 2Leukotriene B4: A Potential Mediator and Biomarker for Cardiac Allograft Vasculopathy - 15 day(s) ago
Cardiac allograft vasculopathy (CAV) remains the leading cause of long-term graft failure and mortality after heart transplantation. Effective preventive and treatment options are not available to-date, largely because underlying mechanisms remain poorly understood. We studied the potential role of leukotriene B4 (LTB4), an inflammatory lipid mediator, in development of CAV.
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Mashup Score: 7Blockade of BLyS inhibits B-cell responses and antibody production for the prevention of chronic transplant rejection - 15 day(s) ago
Chronic rejection, closely related to the activation of B cells and donor-specific antibody (DSA) production, has unsatisfactory therapeutic outcomes. B lymphocyte stimulator (BLyS) is a major regulatory factor that controls the activation and differentiation of B cells. However, it remains unclear whether BLyS blockade can regulate B and plasma cells in the transplantation setting and affect chronic rejection. Here, we investigated the efficacy of the BLyS inhibitors belimumab and telitacicept in controlling B-cell response and preventing chronic rejection.
Source: www.jhltonline.orgCategories: General Medicine News, Cardiology News and JournTweet-
BLyS inhibitors were effective in inhibiting B-cell activation/differentiation, reducing antibody production & prolonging allograft survival. BLyS inhibitors could be used for prevention of chronic rejection in practice. cc @ahajduczok @rachkataria đź”— https://t.co/4jzVWBwp8e https://t.co/uooq3wUYCd
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Mashup Score: 3
Dear Editor,
Source: www.jhltonline.orgCategories: General Medicine News, Cardiology News and JournTweet
Third-time lung transplantation recipients, despite increased operative complexity, demonstrate similar three-year survival compared to matched first-time and repeat lung transplant recipients. @VikramFGupta đź”—: https://t.co/SpoinpKzlu