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Mashup Score: 6
Mendelson et al1 should be congratulated on their pulmonary artery banding (PAB) study in a large animal model. They showed that messenger RNA expression in freshly harvested, pressure-loaded right ventricles (RVs) is different in PAB-piglets vs monocrotaline-exposed rats with pulmonary arterial hypertension (PAH). However, the authors’ claim that the presented PAB-piglet messenger RNA expression signature of fatty acid oxidation (FAO) and electron transport chain (ETC) genes in RV pressure load was more similar to the human expression pattern than the rodent transcriptome is questionable.
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Mashup Score: 32Race, substance use, and evaluation for heart transplantation: insights from a large urban medical center - 2 day(s) ago
It is unknown whether racial disparities in access to heart transplantation (HT) are amplified when coupled with substance use. We examined patients evaluated for HT over eight years at an urban transplant center. We evaluated substance use and race/ethnicity as independent and interactive predictors of HT and left ventricular assist device (LVAD) implantation. Of 1148 patients evaluated for HT, substance use was cited as an ineligibility factor in 151 (13%) patients, 16 (11%) of whom ultimately received HT.
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Mashup Score: 4Exploring a postoperative alternative to intraoperative therapeutic plasma exchange for sensitized lung transplant recipients - 4 day(s) ago
We read with interest the analysis from Saddoughi et al from the Toronto group on the association between intraoperative therapeutic plasma exchange (iTPE) and bleeding in patients undergoing lung transplant when crossing known donor-specific antibodies (DSA).1 Their group is well positioned to tackle this question, having published pioneering work in this area in 2015.2 The present report addresses a perennial concern about the use of iTPE among surgeons, specifically that, in addition to the logistical challenges of coordinating iTPE with intraoperative support modalities, that it could increase intraoperative bleeding and blood product use, and potentially intraoperative complications or the need for return to the operating room to control bleeding.
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Mashup Score: 0Comment on: Detection and management of HLA sensitization in candidates for adult heart transplantation - 7 day(s) ago
Dear Editors,
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Mashup Score: 12Creating superior lungs for transplantation with next-generation gene therapy during ex vivo lung perfusion - 9 day(s) ago
Engineering donor organs to better tolerate the harmful non-immunological and immunological responses inherently related to solid organ transplantation would improve transplant outcomes. Our enhanced knowledge of ischemia-reperfusion injury, alloimmune responses and pathological fibroproliferation after organ transplantation, and the advanced toolkit available for gene therapies, have brought this goal closer to clinical reality. Ex vivo organ perfusion has evolved rapidly especially in the field of lung transplantation, where clinicians routinely use ex vivo lung perfusion (EVLP) to confirm the quality of marginal donor lungs before transplantation, enabling safe transplantation of organs originally considered unusable.
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Mashup Score: 18Impact of anticoagulation intensity on blood transfusion for venoarterial extracorporeal membrane oxygenation during lung transplantation - 10 day(s) ago
Venoarterial extracorporeal membrane oxygenation is increasingly used for mechanical circulatory support during lung transplant. Optimal intensity of intraoperative anticoagulation would be expected to mitigate thromboembolism without increasing bleeding and blood product transfusions. Yet, the optimal intensity of intraoperative anticoagulation is unknown. We performed a retrospective cohort study of 163 patients who received a bilateral lung transplant at a single center. We categorized the intensity of anticoagulation into 4 groups (very low to high) based on the bolus dose of unfractionated heparin given during lung transplant and compared the rates of intraoperative blood transfusions and the occurrence of thromboembolism between groups.
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Mashup Score: 10Advanced hemodynamic and cluster analysis for identifying novel RV function subphenotypes in patients with pulmonary hypertension - 14 day(s) ago
Quantifying right ventricular (RV) function is important to describe the pathophysiology of in pulmonary hypertension (PH). Current phenotyping strategies in PH rely on few invasive hemodynamic parameters to quantify RV dysfunction severity. The aim of this study was to identify novel RV phenotypes using unsupervised clustering methods on advanced hemodynamic features of RV function.
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Mashup Score: 84
Molecular testing with gene expression profiling (GEP) and donor-derived cell-free DNA (dd-cfDNA) is increasingly used in the surveillance for acute cellular rejection (ACR) after heart transplant. However, the performance of dual testing over each test individually has not been established. Further, the impact of dual non-invasive surveillance on clinical decision-making has not been widely investigated.
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Mashup Score: 3Usage of older donors is associated with higher mortality after heart transplantation: A UNOS observational study - 15 day(s) ago
Utilization of heart from older donors is variable across centers with uncertain outcomes of recipients. We sought to utilize a national registry to examine the usage and outcomes of heart transplant (HT) recipients from older donors. We also explored the impact of current donor heart allocation scheme on the outcomes of hearts from older donors.
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Mashup Score: 44
Molecular testing with gene expression profiling (GEP) and donor-derived cell-free DNA (dd-cfDNA) is increasingly used in the surveillance for acute cellular rejection (ACR) after heart transplant. However, the performance of dual testing over each test individually has not been established. Further, the impact of dual non-invasive surveillance on clinical decision-making has not been widely investigated.
Source: www.jhltonline.orgCategories: General Medicine News, CardiologistsTweet
An interesting Letter to the Editor in #JHLT on Mendelson et al. JHLT Feb 2024 - Multi-omic and multispecies analysis of right ventricular dysfunction. cc @SBhattacharyaMD @JasonGoldbergMD @ahajduczok @rachkataria @SSaddoughi @JCFernandezMD 🔗: https://t.co/pCEHNOGVZg