The long-term prognosis of patients with a loss-of-function variant in the cardiac sodium channel gene SCN5A is unknown.

A LAmbre disc occluder (LifeTech Scientific, Shenzhen, China), size 24 to 30 mm (comprising a 24-mm fixed umbrella and a 30-mm sealing disc) was deployed in a wing-shaped left atrial appendage (LAA), with its sealing disc closely attached to the pulmonary ridge (PR; red dashed line) before release. Postrelease, as shown in Figure 1A and the Video, while the umbrella remained in place within the landing zone, the upper part of the sealing disc (yellow dotted line) shifted away from the PR, causing a 3-mm residual leak.

The autonomic nervous system (ANS) is critical to atrial fibrillation (AF) pathophysiology, but it is often difficult to differentiate vagal and adrenergic AF due to complex physiological interactions.1 Early repolarization patterns (ERPs) on electrocardiograms are associated with idiopathic ventricular fibrillation, which often develops in association with increased vagal tone.2 We previously reported that ERPs were associated with increased susceptibility to AF.3 In this study, we evaluated the association between ERP and vagally-mediated AF by assessing the autonomic function using heart rate variability (HRV) and the efficacy of catheter ablation (CA).

Thyroid hormones play a crucial role in cardiovascular physiology. Subclinical thyroid dysfunction has been associated with adverse cardiovascular outcomes, but evidence is mixed regarding causality.