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Mashup Score: 5Frontiers | Don't be a nocebo! Why healthcare organizations should value patients' expectations - 7 hour(s) ago
1 MT3 Clinical Education and Consulting, Coon Rapids, MN, United States 2 Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada 3 Client Experience Company, Los Angeles, CA, United States 4 Department of Medical Sciences, University of Udine, Udine, Italy 5 School of Physiotherapy, University of Verona, Verona, Italy 6 Department of Human Neurosciences, University of Rome “Sapienza Roma”, Rome, Italy 7 Musculoskeletal Pain and Motor Control Research Group, Faculty of Sport
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Mashup Score: 110
Plasmablastic lymphoma (PBL) is an aggressive non-Hodgkin lymphoma associated with HIV infection and immunodeficiency. However, PBL can also be seen immunoco…
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Mashup Score: 10
Necrotizing enterocolitis (NEC) is a devastating disease of the neonatal intestine, causing widespread intestinal necrosis as well systemic illness that frequently results in death. Because the clinical onset of NEC is sudden and difficult to predict, NEC is considered an acute event. However, NEC does not occur in utero, meaning that postnatal exposures are required, and it does not typically occur right after birth, suggesting that longitudinal changes may be occurring before NEC can develop. In this perspective, the author considers whether NEC should be re-considered as a problem of disordered intestinal epithelial development, with required maladaptation over time prior to the onset of the necrotic event. This framework is similar to how bronchopulmonary dysplasia is currently conceptualized. They also advocate that NEC researchers incorporate this possibility into future studies on NEC susceptibility and pathogenesis. Department of Pediatrics, and the Harvard Digestive Disease Ce
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Mashup Score: 108Frontiers | Heterogeneity of macrophage activation syndrome and treatment progression - 2 day(s) ago
Macrophage activation syndrome (MAS) is a rare complication of autoimmune inflammatory rheumatic diseases (AIIRD) characterized by a progressive and life-thr…
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Mashup Score: 8Investigation of causal effects of blood metabolites on insomnia and circadian rhythm sleep wake disorders - 2 day(s) ago
BackgroundInsomnia (IS) and circadian rhythm sleep-wake disorders (CRSWD) are complex disorders with limited and unsatisfactory treatment options that can even cause some side effects. By analyzing blood metabolites to reveal underlying biological processes, studies of sleep and the complex interactions between its influencing factors can be elucidated. Therefore, we hope to bring new hope for the treatment of these diseases through blood metabolites.AimsInvestigating the causal link between blood metabolites and IS and CRSWD.MethodsA genome-wide association study (GWAS) for 486 metabolites was used as the exposure, whereas two different GWAS datasets for sleep disorders were the outcome, and all datasets were obtained from publicly available databases. We employed the standard inverse variance weighting (IVW) method for causal analysis, supported by the MR-Egger method, weighted median (WM) method, and MR-PRESSO method for sensitivity analysis to mitigate the impact of pleiotropy. Gen
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Mashup Score: 0Real-World Challenges for Long-Term Wearable Technologies - 2 day(s) ago
The use of wearable technologies and mobile digital health in neurosciences has shown great potential in advancing our understanding of brain function and improving the diagnosis and management of neurological conditions. However, there are significant challenges that must be addressed before these technologies can be widely adopted in clinical practice and in the real world. These challenges include data privacy and security, user acceptance and adoption, accuracy and reliability, and robustness against real-world artifacts and variability. Moreover, device miniaturization has improved the portability of wearable devices; however, it comes with reduced battery size, hence, there is an urge for wearable solutions that are energy efficient and consume low power to ensure a long battery lifetime. On the other hand, machine learning and deep learning algorithms have proven to be promising for accurate performance, but they are often too resource-demanding for small wearable solutions. The
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Mashup Score: 0Medical Neurohumanities: Sharing Insights from Medicine, Neuroscience and Music in Pediatric Care - 2 day(s) ago
Neurohumanities have long been debated but seldom applied in medicine, with the important relationship between music sciences, music therapy, and pediatric care remaining underexplored. As our understanding of the – young – brain continues to expand, it is crucial to create a shared lexicon that connects music, neuroscience, technological innovations, pediatrics, and healthcare. By fostering interdisciplinary collaboration, we can deepen our comprehension of the working mechanisms of music therapies and medical interventions for pediatric patients. Sharing insights, approaches, methods, and interventions promotes interdisciplinary understanding, enabling the development of more effective, patient-centered healthcare strategies that consider ethical aspects, shared therapeutic goals, and medical responsibilities.The goal is to synergistically integrate knowledge from pediatrics, music therapy, and music medicine to develop purposeful, socially and clinically validated treatments. By mer
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Mashup Score: 6Laparoscopic-assisted Distal Colon Excision and Proximal Colon Pull-through Anorectoplasty for Anorectal Malformation - 3 day(s) ago
Purpose: During the second stage surgery for anorectal malformations (ARM), patients whose distal intestine of the colostomy is particularly short underwent laparoscopic-assisted distal colon excision and proximal colon pull-through anorectoplasty (PCPARP). This study aimed to discuss the outcomes of PCPARP after colostomy in patients with ARM.Methods: This is a single-center propensity score-matched (PSM) study which was retrospectively initiated patients with intermediate- or high-type ARM who underwent laparoscopic surgery from June 2007 to December 2018. These patients were divided into PCPARP group and conventional laparoscopic-assisted anorectoplasty (LAARP) group according to specific surgical methods. The general data, surgical data, postoperative complications, and functional results were evaluated.Results: In total, 216 patients were included in this study: 190 (88.0%) undergoing LAARP approach and 26 (12.0%) undergoing PCPARP approach. After PSM, two well-balanced groups of
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Mashup Score: 0Sleepy and popular? The association between popularity, sleep duration, and insomnia in adolescents - 4 day(s) ago
IntroductionDuring adolescence, peers gain a central role and with the availability of technology, socializing can occur around the clock. Very few studies have focused on the role of peers in adolescents’ sleep using social network analyses. These analyses describe peer relationships and social positions in a defined context (e.g., school) based on friendship nominations. Adolescents who receive many nominations can be defined as “popular,” which has been found to have its costs (i.e., shorter sleep duration) but also benefits (i.e., fewer insomnia symptoms). The aim of this study was to partially replicate and expand previous findings in a large Swedish sample of adolescents.MethodThe sample included 1,394 adolescents (46% girls, Mage = 15.3, SD = 0.53, range 14–18) from 16 public schools in middle Sweden. Adolescents reported on their weekly sleep duration, insomnia symptoms, anxiety, depression, alcohol use, demographics, and nominated up to three friends in school. We used R to ca
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Mashup Score: 0Frontiers | Secondary Immunodeficiency in Hematological Malignancies: Focus on Multiple Myeloma and Chronic Lymphocytic Leukemia - 4 day(s) ago
Secondary immunodeficiency is reported in most patients with hematological malignancies such as chronic lymphocytic leukemia and multiple myeloma. The aim of…
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Don't be a nocebo! Why healthcare organizations should value patients' expectations https://t.co/hO57c9zSdP via @Retlouping et al https://t.co/48y2kTQ0hg