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Mashup Score: 3Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers - 12 day(s) ago
Biological sciences; Cell biology; Biophysics
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 3
Plastic offers a new niche for microorganisms, the plastisphere. The ever-increasing emission of plastic waste makes it critical to understand the microbial ecology of the plastisphere and associated effects. Here, we present a global fingerprint of the plastisphere, analyzing samples collected from freshwater, seawater, and terrestrial ecosystems. The plastisphere assembles a distinct microbial community that has a clearly higher heterogeneity and a more deterministically dominated assembly compared to natural habitats.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet-
Ecology and risks of the global plastisphere as a newly expanding microbial habitat https://t.co/DF4FNMFBWu Top cited 2024 paper from @The_InnovationJ https://t.co/ZxiMWfbg47
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Mashup Score: 4Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress - 12 day(s) ago
Cardiomyocytes exhibit characteristic prominent spatial organizations of heterochromatin (SOH). Fujiwara et al. found that the replacement of endogenous H2B with H2B-mCherry disrupts SOH, leading to extreme elongation of ventricular cardiomyocyte nuclei, resulting in severe heart failure, demonstrating that SOH play a structural role in maintaining nuclear shape against mechanical stress.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet-
Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress. Read more from Kansai Medical University's Maretoshi Hirai & colleagues in @CellReports #bps2025 https://t.co/8wqxmOnhkV
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Mashup Score: 10
In this issue of Cancer Cell, Acha-Sagredo et al. reveal an interferon-high immunophenotype in colorectal cancer that predicts responsiveness to immune checkpoint inhibitors across both mismatch repair-deficient and mismatch repair-proficient subtypes. They identify CD74 as a biomarker and establish the importance of epithelial interferon levels in regulating immune responses.
Source: www.cell.comCategories: General Medicine News, Oncologists1Tweet-
Immunosensitivity cuts across mismatch repair status in colorectal cancer https://t.co/QRdDgp33hJ https://t.co/SacVIR6GYn
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Mashup Score: 4In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313 - 15 day(s) ago
Generating genetically engineered mouse strains for in vivo studies can be a challenging and lengthy process. Nyberg, Wang, Ark, et al. present a method for gene transfer to mouse T cells in vivo using an evolved adeno-associated virus variant and demonstrate the advantages of this method by performing gene delivery, gene editing, and targeted integrations in vivo in immunocompetent mouse model.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Online now: In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313 https://t.co/ke6Irpdu3a
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Mashup Score: 9
Passini et al. found that mice lacking Runx3/PV sensory neurons or lacking Piezo2 in these neurons exhibit a systemic metabolic phenotype with browning/beiging of adipose tissues. Finding Runx3/PV innervation of these tissues suggests a model where mechanoregulation by Piezo2 in sensory neurons protects energy storage and prevents systemic metabolic imbalance.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet-
RT @Cell_Metabolism: New! Online now: Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism https://t.co/7oO1cPxC8s h…
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Mashup Score: 1Squamous cell cancers of the aero-upper digestive tract: A unified perspective on biology, genetics, and therapy - 15 day(s) ago
Henick et al. review aero-upper digestive squamous cell cancers (SCCs) emerging from the head/neck, esophagus, and lung. These SCCs share environmental exposures, dietary/lifestyle factors and genetic features. Patient-derived xenografts, 3D-culture systems, and genetically engineered models recapitulate cardinal disease features to drive translational applications. Emerging therapeutic strategies transcend standard-of-care for these patients.
Source: www.cell.comCategories: General Medicine News, Oncologists1Tweet-
Squamous cell cancers of the aero-upper digestive tract: A unified perspective on biology, genetics, and therapy https://t.co/D6QQ3oL56C https://t.co/mmzngjBk4C
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Mashup Score: 59NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression - 15 day(s) ago
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibition of NLRP3 increases glutamine utilization and α-ketoglutarate, which triggers downstream epigenetic changes allowing acetylation of target phagocytic and metabolic genes. This microglial reprogramming has implications for dementia and AD therapies.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Online now: NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression https://t.co/tIHZT1VO0D
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Mashup Score: 4Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination - 16 day(s) ago
Liver tissue-resident memory T (Trm) cells are important for liver-stage malaria immunity. Chua et al. demonstrate that optimal generation of long-lived liver Trm cells requires priming by cDC1, post-priming exposure to antigen and inflammation, and consideration of the timing and types of vaccine boosters. These findings inform future vaccine design.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet-
Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination https://t.co/YCUfrh1YAL
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Mashup Score: 61Recirculating regulatory T cells mediate thymic regeneration through amphiregulin following damage - 16 day(s) ago
Thymic injury leads to reduced T cell production and makes patients more vulnerable to infections and cancers. Lemarquis et al. identify a population of recirculating regulatory T (Treg) cells that mediate regeneration in the injured thymus, partially through amphiregulin. An analogous population of Treg cells expressing CD39 and ICOS is found in humans, suggesting therapeutic avenues for boosting thymic regeneration to address aging- and treatment-induced immunosuppression.
Source: www.cell.comCategories: General Medicine News, Allergy-ImmunologyTweet-
Online now: Recirculating regulatory T cells mediate thymic regeneration through amphiregulin following damage https://t.co/55LFz85lIi
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Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers. A study by Kanazawa Institute of Technology's Hiroaki Hirata & others in @iScience_CP #bps2025 https://t.co/bCEwoIfmbh