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Mashup Score: 0
Rationale: Idiopathic pulmonary fibrosis (IPF) causes progressive lung scarring and high mortality. Reliable and accurate prognostic biomarkers are urgently needed. Objectives: To identify and vali…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 0Zinpentraxin Alfa for Idiopathic Pulmonary Fibrosis: The Randomized Phase III STARSCAPE Trial - 3 hour(s) ago
Rationale: A phase II trial reported clinical benefit over 28βweeks in patients with idiopathic pulmonary fibrosis (IPF) who received zinpentraxin alfa. Objectives: To investigate the efficacy and …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 0Gazing into the Proteomic Crystal Ball: Predicting Survival in Idiopathic Pulmonary Fibrosis - 12 hour(s) ago
In many respects, idiopathic pulmonary fibrosis (IPF) is a predictable disease. It is a condition characterized by inevitable and usually inexorable progression with an untreated median survival of between 3 and 5 years (1). However, a look beyond population-level statistics and examination of the disease behavior of individual patients reveals considerable heterogeneity. Some individuals have rapidly progressive disease and die within months of diagnosis, whereas others have relatively indolent disease,
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 2Validation of Constant Work Rate Cycling Endurance Time for Use in Chronic Obstructive Pulmonary Disease Clinical Trials - 14 hour(s) ago
Rationale: A COPD Foundation working group sought to identify measures of exercise endurance, a meaningful aspect of physical functioning in everyday life among patients with chronic obstructive pu…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 14
Rationale: Oral microbiota associate with diseases of the mouth and serve as a source of lung microbiota. However, the role of oral microbiota in lung disease is unknown. Objectives: To determine a…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 1Mandibular Jaw Movement Automated Analysis for Oral Appliance Monitoring in Obstructive Sleep Apnea: A Prospective Cohort Study - 1 day(s) ago
Rationale: Oral appliances are second-line treatments after continuous positive airway pressure for obstructive sleep apnea (OSA) management. However, the need for oral appliance titration limits t…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 1
Rationale: Computed tomography (CT) enables noninvasive diagnosis of usual interstitial pneumonia (UIP), but enhanced image analyses are needed to overcome the limitations of visual assessment. Obj…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 16
Few observations in the field of the airway microbiome have been as consistently replicated as the one in which high bacterial burden in the lower airways is associated with poor prognosis in idiopathic pulmonary fibrosis (IPF) (1 β 4). The excitement around that observation led the NIH to support a clinical trial using antibiotics as a potential approach to this condition. The hope was so great that even the name of the trial was optimistic: CleanUP-IPF. It was a multicenter, randomized placebo-controlled
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 2When a DEAD-Box Protein Is the Key: A Novel Role for DDX5 in Lung Pericyte Dysfunction - 2 day(s) ago
Intrauterine growth restriction (IUGR) is characterized by fetal weight below the 10th percentile per gestational age, increased risk for various conditions, and premature death (1). Infants with IUGR are at an increased risk of the development of pulmonary hypertension (PH), a devastating condition characterized by increased pulmonary artery pressures and remodeling of the pulmonary vasculature (1). Among the potential causes of IUGR-associated PH is the arrested development of the pulmonary vascular
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 0
Oral appliances such as mandibular advancement devices (MADs) form a core treatment of obstructive sleep apnea (OSA). These devices treat OSA by increasing the size of the upper airway and are recommended for patients with OSA who do not tolerate continuous positive airway pressure or prefer another treatment option (1). To effectively treat OSA, MADs must be tailored to the individual. Beyond customization to the patientβs oropharyngeal anatomy, the degree of mandibular protrusion must also be tailored
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
The Blue Journal thanks Christopher Ting, MD, for his contribution to the May 1 issue Proteomic Biomarkers of Survival in Idiopathic Pulmonary Fibrosis @RachelZemans @MichiganPulmCC https://t.co/kxdikOHOWl https://t.co/FQ7d3lTOoW