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Mashup Score: 0
Idiopathic pulmonary fibrosis (IPF) is an aggressive and, thus far, incurable disease characterized by aberrant fibroblast-mediated extracellular matrix deposition. Our understanding of the disease…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 3Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis - 3 day(s) ago
The mortality associated with acute lung injury (ALI) increases with age. Alveolar epithelial type II (AEII) cells are the progenitor cells of the alveolar epithelium and are crucial for repair aft…
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Mashup Score: 0Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis - 4 day(s) ago
The biological mediators that initiate lung injury in extremely preterm infants during early postnatal life remain largely unidentified, limiting opportunities for early treatment and diagnosis. In…
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Mashup Score: 2Piecing Together the Role of IL-4 Receptor Alpha in Allergic Asthma One Cell at a Time - 6 day(s) ago
IL-4 receptor ฮฑ (IL-4Rฮฑ) has become a main target of allergic disease therapy since the initial studies of blocking antibodies to IL-4Rฮฑ in mice over 20 years ago, yet which patients will benefit from treatment and how modulating IL-4Rฮฑ alters disease activity are unknown. In this issue of the Journal, Choudhary and colleagues (pp. 702โ717) report on their work that takes steps toward exploring this question by recapitulating key experiments over the past 2 decades to explore the cell typeโspecific roles
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Mashup Score: 2
The American Journal of Respiratory Cell and Molecular Biology (AJRCMB) is issuing a call for papers: โDevelopmental Origins of Lung Disease Across the Life Span.โ This call aligns with the Basic Science Core topic for the 2025 ATS International Conference. We aim to showcase work that investigates the mechanisms for early-life origins of lung diseases, including genetics and in utero or early-life exposures that regulate inflammation, tissue development, repair, and fibrosis, and that shape lung structure
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Mashup Score: 3ATS Red Journal (@ajrcmb.bsky.social) - 9 day(s) ago
Posting content from the American Journal of Respiratory Cell and Molecular Biology; follows do not indicate endorsement. #ATS #AJRCMB #RedJournal https://www.atsjournals.org/journal/ajrcmb
Source: bsky.appCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 0
Chronic kidney disease (CKD), a progressive condition affecting millions globally, is characterized by the irreversible loss of kidney function. This results in a decreased ability to excrete phosphate, leading to hyperphosphatemia, a condition marked by systemically elevated phosphate concentrations in the blood (1). Hyperphosphatemia is associated with increased inflammation and cardiovascular and pulmonary diseases, including fibrotic interstitial lung diseases (2). Historically, however, the focus of
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Mashup Score: 2Enzymatic Modulation of the Pulmonary Glycocalyx Enhances Susceptibility to Streptococcus pneumoniae - 10 day(s) ago
The pulmonary epithelial glycocalyx is rich in glycosaminoglycans such as hyaluronan and heparan sulfate. Despite their presence, the importance of these glycosaminoglycans in bacterial lung infect…
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Mashup Score: 2Respiratory Epithelial Cell Surface Decoration Provides Defense against Bacterial Damage during Infection - 10 day(s) ago
Pneumonia kills people. In 2017, the World Health Organization reported that pneumonia was responsible for 15% of all deaths of children < 5 years of age (1). A healthy respiratory epithelial layer provides a physical barrier to withstand assault by inhaled foreign particles and microbes, while being thin enough to support respiration. Extending apically into the lung from the surface of respiratory epithelial cells is a mesh-like glycocalyx composed of proteoglycans, glycoprotei ns, and glycosaminoglycans
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Mashup Score: 0Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis - 11 day(s) ago
“.” American Journal of Respiratory Cell and Molecular Biology, 71(6), pp.
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
A Redox-Shifted Fibroblast Subpopulation Emerges in the Fibrotic Lung ๐ Open Access ๐ https://t.co/KFmJDfNvuy https://t.co/gwEe8ZtYFt