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Mashup Score: 6Engineering blood and lymphatic microvascular networks - 8 day(s) ago
The human vasculature plays a crucial role in the blood supply of nearly all organs as well as the drainage of the interstitial fluid. Consequently, if these physiological systems go awry, pathological changes might occur. Hence, the regeneration of existing vessels, as well as approaches to engineer artificial blood and lymphatic structures represent current challenges within the field of vascular research. In this review, we provide an overview of both the vascular blood circulation and the long-time neglected but equally important lymphatic system, with regard to their organotypic vasculature.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 11Sex differences in lipids: A life course approach - 8 day(s) ago
Differences between men and women in lipids and lipoproteins are observed in distribution and trajectory from infancy to adulthood in the general population. However, these differences are more pronounced in hereditary lipid disorders such as familial hypercholesterolemia (FH) when absolute cholesterol levels are higher from birth onwards. In the early life course, girls compared to boys have higher low-density lipoprotein cholesterol (LDL-C) levels and total cholesterol, while high-density lipoprotein cholesterol (HDL-C) levels are similar.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 19Subclinical atherosclerosis in young adults predicting cardiovascular disease: The Cardiovascular Risk in Young Finns Study - 12 day(s) ago
Atherosclerosis is accompanied by pre-clinical vascular changes that can be detected using ultrasound imaging. We examined the value of such pre-clinical features in identifying young adults who are at risk of developing atherosclerotic cardiovascular disease (ASCVD).
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 7
High coronary artery calcification (CAC) burden is a significant risk factor for adverse cardiovascular and kidney outcomes. However, it is unknown whether changes in the coronary atherosclerotic burden can accompany changes in kidney disease progression. Here, we evaluated the relationship between CAC progression and the risk of kidney failure with replacement therapy (KFRT).
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 17Remnant cholesterol, LDL cholesterol, and apoB absolute mass changes explain results of the PROMINENT trial. - 12 day(s) ago
The PROMINENT trial, a cardiovascular outcome trial of the triglyceride- and remnant cholesterol-lowering agent pemafibrate, has shown neutral results despite reduction in plasma triglycerides and remnant cholesterol. We tested the hypothesis that absolute mass changes in remnant cholesterol, LDL cholesterol, and apolipoprotein B explain the results of the PROMINENT trial.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 15Adiposity, type 2 diabetes and atherosclerotic cardiovascular disease risk: Use and abuse of the body mass index - 16 day(s) ago
The worldwide prevalence of individuals with an elevated body weight has increased steadily over the past five decades. Billions of research dollars have been invested to improve our understanding of the causes and consequences of having an elevated body weight. All this knowledge has however failed to influence populational body weight trajectories of most countries around the world. Research on the definition of “obesity” has also evolved. The body mass index (BMI), the tool most commonly used to make its diagnosis, has major limitations.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 16
Carriers of the E40K loss-of-function variant in Angiopoietin-like 4 (ANGPTL4), have lower plasma triglyceride levels as well as lower rates of coronary artery disease (CAD) and type 2 diabetes (T2D). These genetic data suggest ANGPTL4 inhibition as a potential therapeutic target for cardiometabolic diseases. However, it is unknown whether the association between E40K and human diseases is due to linkage disequilibrium confounding. The broader impact of genetic ANGPTL4 inhibition is also unknown, raising uncertainties about the safety and validity of this target.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 20
The effects of protein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on endothelial function as assessed by flow-mediated dilation (FMD) in patients with acute myocardial infarction (AMI) are unknown. Therefore, we aimed to investigate the effects of the PCSK9 inhibitor alirocumab added to high-intensity statin on FMD, and its association with coronary atherosclerosis in non-infarct related arteries using intracoronary intravascular ultrasound (IVUS), near-infrared spectroscopy (NIRS), and optical coherence tomography (OCT).
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 85Coronary artery calcium as a marker of healthy and unhealthy aging in adults aged 75 and older: The Atherosclerosis Risk in Communities (ARIC) study - 1 month(s) ago
Coronary artery calcium (CAC) is validated for risk prediction among middle-aged adults, but there is limited research exploring implications of CAC among older adults. We used data from the Atherosclerosis Risk in Communities (ARIC) study to evaluate the association of CAC with domains of healthy and unhealthy aging in adults aged ≥75 years.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 85Coronary artery calcium as a marker of healthy and unhealthy aging in adults aged 75 and older: The Atherosclerosis Risk in Communities (ARIC) study - 1 month(s) ago
Coronary artery calcium (CAC) is validated for risk prediction among middle-aged adults, but there is limited research exploring implications of CAC among older adults. We used data from the Atherosclerosis Risk in Communities (ARIC) study to evaluate the association of CAC with domains of healthy and unhealthy aging in adults aged ≥75 years.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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