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Mashup Score: 18Subclinical atherosclerosis in young adults predicting cardiovascular disease: The Cardiovascular Risk in Young Finns Study - 1 day(s) ago
Atherosclerosis is accompanied by pre-clinical vascular changes that can be detected using ultrasound imaging. We examined the value of such pre-clinical features in identifying young adults who are at risk of developing atherosclerotic cardiovascular disease (ASCVD).
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 7
High coronary artery calcification (CAC) burden is a significant risk factor for adverse cardiovascular and kidney outcomes. However, it is unknown whether changes in the coronary atherosclerotic burden can accompany changes in kidney disease progression. Here, we evaluated the relationship between CAC progression and the risk of kidney failure with replacement therapy (KFRT).
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 17Remnant cholesterol, LDL cholesterol, and apoB absolute mass changes explain results of the PROMINENT trial. - 1 day(s) ago
The PROMINENT trial, a cardiovascular outcome trial of the triglyceride- and remnant cholesterol-lowering agent pemafibrate, has shown neutral results despite reduction in plasma triglycerides and remnant cholesterol. We tested the hypothesis that absolute mass changes in remnant cholesterol, LDL cholesterol, and apolipoprotein B explain the results of the PROMINENT trial.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 15Adiposity, type 2 diabetes and atherosclerotic cardiovascular disease risk: Use and abuse of the body mass index - 5 day(s) ago
The worldwide prevalence of individuals with an elevated body weight has increased steadily over the past five decades. Billions of research dollars have been invested to improve our understanding of the causes and consequences of having an elevated body weight. All this knowledge has however failed to influence populational body weight trajectories of most countries around the world. Research on the definition of “obesity” has also evolved. The body mass index (BMI), the tool most commonly used to make its diagnosis, has major limitations.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 16
Carriers of the E40K loss-of-function variant in Angiopoietin-like 4 (ANGPTL4), have lower plasma triglyceride levels as well as lower rates of coronary artery disease (CAD) and type 2 diabetes (T2D). These genetic data suggest ANGPTL4 inhibition as a potential therapeutic target for cardiometabolic diseases. However, it is unknown whether the association between E40K and human diseases is due to linkage disequilibrium confounding. The broader impact of genetic ANGPTL4 inhibition is also unknown, raising uncertainties about the safety and validity of this target.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 20
The effects of protein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on endothelial function as assessed by flow-mediated dilation (FMD) in patients with acute myocardial infarction (AMI) are unknown. Therefore, we aimed to investigate the effects of the PCSK9 inhibitor alirocumab added to high-intensity statin on FMD, and its association with coronary atherosclerosis in non-infarct related arteries using intracoronary intravascular ultrasound (IVUS), near-infrared spectroscopy (NIRS), and optical coherence tomography (OCT).
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 85
Coronary artery calcium (CAC) is validated for risk prediction among middle-aged adults, but there is limited research exploring implications of CAC among older adults. We used data from the Atherosclerosis Risk in Communities (ARIC) study to evaluate the association of CAC with domains of healthy and unhealthy aging in adults aged ≥75 years.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 85
Coronary artery calcium (CAC) is validated for risk prediction among middle-aged adults, but there is limited research exploring implications of CAC among older adults. We used data from the Atherosclerosis Risk in Communities (ARIC) study to evaluate the association of CAC with domains of healthy and unhealthy aging in adults aged ≥75 years.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 7
Hypercholesterolemia (HC) has previously been shown to augment the restenotic response in animal models and humans. However, the mechanistic aspects of in-stent restenosis (ISR) on a hypercholesterolemic background, including potential augmentation of systemic and local inflammation precipitated by HC, are not completely understood. CD47 is a transmembrane protein known to abort crucial inflammatory pathways. Our studies have examined the interrelation between HC, inflammation, and ISR and investigated the therapeutic potential of stents coated with a CD47-derived peptide (pepCD47) in the hypercholesterolemic rabbit model.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 11
High levels of lipoprotein(a) [Lp(a)] are associated with increased risk of acute coronary syndrome (ACS). We explored whether Lp(a) exhibits a stronger association with premature ACS.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
Subclinical atherosclerosis in young adults predicting cardiovascular disease. Interesting but #IMT is arterial remodelling and may be separate from #atherosclerosis in my view. https://t.co/luwFqJENd1