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Mashup Score: 1Associations of high-density lipoprotein cholesterol levels with the presence and severity of coronary atherosclerosis - 1 day(s) ago
Emerging evidence suggest a controversial relationship between high-density lipoprotein cholesterol (HDL-C) and adverse cardiovascular outcomes. We aimed to explore the associations of serum HDL-C levels with the presence and severity of coronary artery disease (CAD) in patients who underwent coronary angiography using a real-life clinical database.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 1Liver metabolism in human MASLD: A review of recent advancements using human tissue metabolomics - 1 day(s) ago
Global incidence of Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) is on the rise while treatments remain elusive. MASLD is a disease of dysregulated systemic and hepatic metabolism. Current understanding of disease pathophysiology as it relates to metabolome changes largely comes from studies on animal models and human plasma. However, human tissue data are crucial for transitioning from mechanisms to clinical therapies. The close relationship between MASLD and comorbidities like obesity, type 2 diabetes and dyslipidemia make it difficult to determine the contribution from liver disease itself.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 1Statin adherence in coronary outpatients: the relationship between a novel blood test and pharmacy registry data - 20 day(s) ago
An accurate and feasible method to assess adherence to statin therapy is needed. We developed a novel blood test to identify reduced statin adherence and compared statin adherence determined by a single blood test to pharmacy registry data.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 5Achieved Levels of Apolipoprotein B and Plaque Composition After Acute Coronary Syndromes: Insights from HUYGENS - 20 day(s) ago
Addition of the PCSK9 inhibitor, evolocumab, to statin therapy promoted coronary plaque stabilization after an acute coronary syndrome. While apolipoprotein B (ApoB) has been proposed as a goal for lipid-lowering therapy in the prevention of cardiovascular disease, its association with plaque stability has not been studied.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 3Causation and Association of Remnant Cholesterol with Cardiovascular Outcomes Do Not Imply Clinical Utility: A Call for Action - 1 month(s) ago
Remnant cholesterol (remnant-C) has emerged as a significant cardiovascular (CV) risk factor, complementing the traditional focus on low-density lipoprotein cholesterol (LDL-C). Recent years have witnessed an increased understanding of remnant-C’s atherogenicity, highlighting its prominent role in the residual risk of cardiovascular events, even after LDL-C reduction (1, 2). Interestingly, the widespread use of LDL-C-lowering drugs has overshadowed the understanding of remnant-C as a causal CV risk factor for over 30 years.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 50
What was known ?
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 21
Statins, ezetimibe and statins-ezetimibe combination therapy are recommended lipid-lowering therapies (LLTs) in children with heterozygous familial hypercholesterolaemia (HeFH). However, their relative effectiveness is not well understood. We aimed to compare the safety and efficacy of these therapies using direct and indirect comparisons.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 1
Lipoprotein(a) [Lp(a)] is a causal, genetically determined cardiovascular risk factor. Limited evidence suggests that dietary unsaturated fat may increase serum Lp(a) concentration by 10–15 %. Linoleic acid may increase Lp(a) concentration through its endogenous conversion to arachidonic acid, a process regulated by the fatty acid desaturase (FADS) gene cluster. We aimed to compare the Lp(a) and other lipoprotein trait-modulating effects of dietary alpha-linolenic (ALA) and linoleic acids (LA). Additionally, we examined whether FADS1 rs174550 genotype modifies Lp(a) responses.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, Partners & KOLsTweet
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Mashup Score: 50
What was known ?
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 29ApoB-100: The guardian of LDL stability - 2 month(s) ago
Low-density lipoprotein (LDL) particles are composed of a core containing cholesteryl esters and some triglycerides, surrounded by a monolayer of phospholipids and unesterified cholesterol. This structure is stabilized by a single apolipoprotein B-100 (apoB-100), which is anchored on the surface of the particle. This structure enables LDL particles to efficiently transport cholesterol through the bloodstream to peripheral tissues. However, once LDL particles are retained in the arterial intima, they become vulnerable to modifications—such as lipolysis—that promote particle aggregation1-3.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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