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Mashup Score: 7
Hypercholesterolemia (HC) has previously been shown to augment the restenotic response in animal models and humans. However, the mechanistic aspects of in-stent restenosis (ISR) on a hypercholesterolemic background, including potential augmentation of systemic and local inflammation precipitated by HC, are not completely understood. CD47 is a transmembrane protein known to abort crucial inflammatory pathways. Our studies have examined the interrelation between HC, inflammation, and ISR and investigated the therapeutic potential of stents coated with a CD47-derived peptide (pepCD47) in the hypercholesterolemic rabbit model.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 11High levels of lipoprotein (a) and premature acute coronary syndrome - 1 month(s) ago
High levels of lipoprotein(a) [Lp(a)] are associated with increased risk of acute coronary syndrome (ACS). We explored whether Lp(a) exhibits a stronger association with premature ACS.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 5Short-term air pollution exposure and mechanisms of plaque instability in acute coronary syndromes: An optical coherence tomography study - 1 month(s) ago
Air pollution is emerging as an important risk factor for acute coronary syndrome (ACS). In this study, we investigated the association between short-term air pollution exposure and mechanisms of coronary plaque instability evaluated by optical coherence tomography (OCT) imaging in ACS patients.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 7Use of heated tobacco products (IQOS) causes an acute increase in arterial stiffness and platelet thrombus formation - 2 month(s) ago
Heated tobacco products (HTPs) are novel alternative tobacco products being promoted as an alternative to cigarettes. To evaluate the impact of HTP use on vascular function, we investigated the effects of a brief HTP usage on arterial stiffness and platelet thrombus formation in healthy volunteers.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet-
Brief HTP (IQOS 3 Multi) use in healthy young adults had immediate adverse effects on vascular function resulting in increased arterial stiffness and platelet thrombus formation, known risk factors for atherosclerosis https://t.co/A8zpfjMUQE #HEETS #IQOS @ATHjournal @InsidePMI https://t.co/EMuznMPaf0
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Mashup Score: 29Rosuvastatin effect on atherosclerotic plaque metabolism: A subclinical atherosclerosis imaging study with 18F–NaF PET-CT - 2 month(s) ago
Atherosclerotic plaque fluorine-18 sodium fluoride (18F–NaF) uptake on positron emission tomography with computed tomography (PET-CT) identifies active microcalcification and has been shown to correlate with clinical instability in patients with cardiovascular (CV) disease. Statin therapy promotes coronary macrocalcification over time. Our aim was to investigate rosuvastatin effect on atheroma 18F–NaF uptake.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 32Impact of optimal cholesterol levels on subclinical atherosclerosis in the absence of risk factors in young adults - 2 month(s) ago
To assess the association of blood lipids with the prevalence, incidence, and progression of subclinical atherosclerosis among young individuals without dyslipidemia and other traditional cardiovascular risk factors (CVRFs).
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 82Coronary artery calcium as a marker of healthy and unhealthy aging in adults aged 75 and older: The Atherosclerosis Risk in Communities (ARIC) study - 2 month(s) ago
Coronary artery calcium (CAC) is validated for risk prediction among middle-aged adults, but there is limited research exploring implications of CAC among older adults. We used data from the Atherosclerosis Risk in Communities (ARIC) study to evaluate the association of CAC with domains of healthy and unhealthy aging in adults aged ≥75 years.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 5Engineering blood and lymphatic microvascular networks - 2 month(s) ago
The human vasculature plays a crucial role in the blood supply of nearly all organs as well as the drainage of the interstitial fluid. Consequently, if these physiological systems go awry, pathological changes might occur. Hence, the regeneration of existing vessels, as well as approaches to engineer artificial blood and lymphatic structures represent current challenges within the field of vascular research. In this review, we provide an overview of both the vascular blood circulation and the long-time neglected but equally important lymphatic system, with regard to their organotypic vasculature.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 11
Inclisiran, an siRNA therapy, consistently reduces low-density lipoprotein cholesterol (LDL-C) with twice-yearly dosing. Potential cardiovascular benefits of implementing inclisiran at a population level, added to statins, were evaluated through simulation.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 3
Hypercholesterolemia (HC) has previously been shown to augment the restenotic response in animal models and humans. However, the mechanistic aspects of in-stent restenosis (ISR) on a hypercholesterolemic background, including potential augmentation of systemic and local inflammation precipitated by HC, are not completely understood. CD47 is a transmembrane protein known to abort crucial inflammatory pathways. Our studies have examined the interrelation between HC, inflammation, and ISR and investigated the therapeutic potential of stents coated with a CD47-derived peptide (pepCD47) in the hypercholesterolemic rabbit model.
Source: www.atherosclerosis-journal.comCategories: General Medicine News, Cardiology News and JournTweet
Hypercholesterolemia exacerbates in-stent restenosis #ISR - #Atherosclerosis https://t.co/9vKZoJREEs