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Mashup Score: 90Understanding T-cell responses to COVID-19 is essential for informing public health strategies - 3 year(s) ago
Assessing T-cell immunity and antibody levels in surveillance studies could provide a better profile of adaptive immunity to SARS-CoV-2.
Source: Science ImmunologyCategories: Expert Picks, Latest HeadlinesTweet
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Mashup Score: 24Understanding T-cell responses to COVID-19 is essential for informing public health strategies - 3 year(s) ago
Assessing T-cell immunity and antibody levels in surveillance studies could provide a better profile of adaptive immunity to SARS-CoV-2.
Source: Science ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
A Viewpoint by @SantoshVardhana @LanceBaldoMD @moricemdphd and @EJohnWherry explains how #Tcell testing can help research on population-level #SARSCoV2 #AdaptiveImmunity and inform public health policies. https://t.co/D1kyMWLBrX https://t.co/bgoPtn7ePb
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Mashup Score: 11Transforming growth factor–β1 in regulatory T cell biology - 3 year(s) ago
TGF-β1 is a pleiotropic cytokine that modulates Treg biology and function, with critical roles in the etiology of cancer and fibrosis.
Source: Science ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
Manipulating the way TGF-β interacts with regulatory T cells to develop disease therapies will be a goal for future research, predict @MoreauJoshua, @Treg_Mike and @Zihai in a new Review. https://t.co/d0KVEXCLYJ https://t.co/W4Z6oTeUYk
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Mashup Score: 15Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood - 3 year(s) ago
Human MZB cell subsets differ in cell surface, transcriptome, clone relatives, mutation burden, microanatomy, and relevance to disease.
Source: Science ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
A new study by @BemarkMats and colleagues used #scRNAseq to characterize 2 new subsets of human marginal zone #Bcells in matched samples across #lymphoid organs. https://t.co/mpEQgQPk8L https://t.co/lz4zH2XHb6
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Mashup Score: 11
We review the compartment-specific identities of the various types of tissue-embedded and fluid-immersed CNS macrophages.
Source: Science ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
Researchers @EdinburghUni and @VUBrussel summarize what’s known about central nervous system #macrophages, proposing that cerebrospinal fluid macrophages are a distinct population. https://t.co/zcYdzAFjgu https://t.co/5BbpZe7TgE
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Mashup Score: 6Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells - 3 year(s) ago
PU.1, IRF8, and BATF3 cooperation and inflammatory signaling orchestrate efficient programming of human cDC1-like cells.
Source: Science ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
New study uses single cell transcriptomics to optimize reprogramming of human #fibroblasts into cross-presenting #DendriticCells with high efficiency. https://t.co/qo98aZbhyk https://t.co/pVZI9QMyrA
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Mashup Score: 12
Tuft cells in the biliary tree are bile-sensitive cells that, together with the microbiome, regulate biliary inflammatory tone.
Source: Science ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
Bile acids negatively regulate #TuftCells in the gallbladder, indicates new research in mice using #FlowCytometry and bulk #RNAsequencing. https://t.co/N5I3IQHZra https://t.co/e6mXrKDK0F
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Mashup Score: 33
Sensing of propionate by gallbladder tuft cells triggers innate responses by corelease of acetylcholine and cysteinyl leukotrienes.
Source: Science ImmunologyCategories: Future of Medicine, Latest HeadlinesTweet-
An #optogenetics model in mice suggests microbial metabolite propionate triggers #TuftCells in the gallbladder to mediate mucus secretion and smooth muscle contractions. https://t.co/kEhN7HQHhi @SciImmunology https://t.co/2itaJIc3zF
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Mashup Score: 5Contents | Science Immunology 7, 69 - 3 year(s) ago
Science Immunology Volume 7|Issue 69|Mar 2022 ONLINE COVER Tickling Tuft Cells with Photons. This month’s cover cover shows a pulse of blue light illuminating mouse gallbladder tissue mounted in an organ bath. Using tissue from transgenic mice expressing a…
Source: Science ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
The new March issue of Science #Immunology is out! The cover article identifies a microbial metabolite trigger for biliary #TuftCells immune responses. Related research suggests #BileAcids negatively regulates tuft cells in the gallbladder. Find more here: https://t.co/xRVB68luQK https://t.co/mhUlKeq1tt
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Mashup Score: 12An IL-9–pulmonary macrophage axis defines the allergic lung inflammatory environment - 3 year(s) ago
IL-9 promotes allergic inflammation by altering the heterogeneity and function of lung macrophages.
Source: Science ImmunologyCategories: Future of Medicine, Latest HeadlinesTweet-
New research on pulmonary #macrophages emphasizes the link between the protein IL-9 and #asthma, implicating interstitial macrophages as the cytokine’s key cellular target. https://t.co/5UB5zNQ8l4 @SciImmunology https://t.co/iz21zp7pLL
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Instead of antibody-centric guidance, the case for broad use of T-cell assays to "decrease our vulnerability to a virus that has proven to be a formidable adversary" https://t.co/ud5PnBqNQM @SciImmunology 💯 long overdue by @SantoshVardhana @LanceBaldoMD @moricemdphd @EJohnWherry