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Mashup Score: 0Variation in Endpoints in FDA Medication Approvals: A Review of Acute and Preventive Migraine Medications - 2 year(s) ago
Background and Objective: To assess the characteristics and extent of variation of the endpoints used in trials supporting FDA approval of medications treating migraine. Methods: Using the Drugs@FDA online database, we identified novel prescription medications approved by the FDA between January 2001 and September 2022, for migraine with or without aura, for both acute and preventive treatment,…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 4Economic Cost of Functional Neurologic Disorders - 2 year(s) ago
Background and Objectives Functional neurologic disorder (FND) represents genuine involuntary neurologic symptoms and signs including seizures, weakness, and sensory disturbance, which have characteristic clinical features, and represent a problem of voluntary control and perception despite normal basic structure of the nervous system. The historical view of FND as a diagnosis of exclusion can…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
Economic Cost of Functional Neurologic Disorders: A Systematic Review https://t.co/fwswHzMxMY #NeuroTwitter
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Mashup Score: 1
A 61-year-old woman presented with subacute excessive sweating, dizziness, and cognitive impairment. Neurologic examination was unremarkable, and Mini-Mental State Examination score was 13 with disorientation and dyscalculia. Extensive workup revealed only mild hyponatremia (sodium 132 mmol/L) and dysautonomia with hyperhidrosis and orthostatic hypotension. Brain MRI fluid-attenuated inversion…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
Teaching NeuroImage: Glucose Hypermetabolism in the Basal Ganglia—The Decisive Clue to the Diagnosis of an Unusual Anti-LGI1 Encephalitis https://t.co/GYR9msYcuH #NeurologyRF #NeuroTwitter https://t.co/8vhqtTm7Qk
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Mashup Score: 0Association of Performance on Olfactory and Cognitive Screening Tests With Conversion to Dementia in a Biracial Cohort of Older Adults - 2 year(s) ago
Background and Objectives: Odor identification deficits are associated with transition to dementia, whereas intact odor identification and global cognition test performance may identify lack of transition. The purpose of this study is to examine intact odor identification and global cognition as prognostic indicators of lack of transition to dementia in a biracial (Black and White)…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
Via @GreenJournal: Tests for odor identification and cognition together identified people at low risk for #dementia, which could reduce the need for extensive diagnostic testing: https://t.co/nXtvEQQkfu #neurotwitter #Alzheimers @AANMember https://t.co/9kv1u4fe4i
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Mashup Score: 1Effects of Cerebrovascular and Lewy Body Pathology on Parkinsonian Signs in Community-Dwelling Older Adults - 2 year(s) ago
Background and Objectives: The roles of Lewy body (LB) and separately of cerebrovascular disease (CVD) pathologies in the severity of parkinsonian signs are well recognized in old age. We investigated whether the two pathologies act synergistically to further potentiate the severity of parkinsonism beyond their separate effects. Methods: We employed postmortem data of decedents from 3…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
"These findings suggest that atherosclerosis and macroscopic infarcts interact with Lewy body pathology to increase the severity of parkinsonism beyond their additive effects in older persons" https://t.co/X5vf6rNXOo
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Mashup Score: 11Associations of Blood Cardiovascular Biomarkers With Brain Free Water and Its Relationship to Cognitive Decline - 2 year(s) ago
Background and Objectives There is an increasing awareness of the “Heart-Brain Connection,” whereby cardiovascular function is connected with cognition. Diffusion-MRI studies reported higher brain free water (FW) was associated with cerebrovascular disease (CeVD) and cognitive impairment. In this study, we investigated whether higher brain FW was related to blood cardiovascular biomarkers and…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
Associations of Blood Cardiovascular Biomarkers With Brain Free Water and Its Relationship to Cognitive Decline: A Diffusion-MRI Study https://t.co/hTfEWYaeFt #NeuroTwitter https://t.co/YNQSZ79v8z
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Mashup Score: 0The Association between Ischemic Stroke Subtype and Stroke Severity: The Atherosclerosis Risk in Communities Study - 2 year(s) ago
Background and Objectives: Disability after stroke occurs across ischemic stroke subtypes, with a suggestion that embolic strokes are more devastating. Whether this difference is as a result of differences in comorbidities, or differences in severity at the time of the stroke event is not known. The primary hypothesis was that participants with embolic stroke would have more severe stroke at the…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
Via @GreenJournal: Embolic stroke was associated with increases in both #stroke severity and risk of death versus thrombotic stroke: https://t.co/s5AWS8dR7W #neurotwitter @AANMember https://t.co/XukFr6PjzD
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Mashup Score: 2Associations of CSF PDGFRβ With Aging, Blood-Brain Barrier Damage, Neuroinflammation, and Alzheimer Disease Pathologic Changes - 2 year(s) ago
Background and Objectives Injured pericytes in the neurovascular unit release platelet-derived growth factor β (PDGFRβ) into the CSF. However, it is not clear how pericyte injury contributes to Alzheimer disease (AD)–related changes and blood-brain barrier (BBB) damage. We aimed to test whether CSF PDGFRβ was associated with different AD-associated and age-associated pathologic changes leading to…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
This study found that pericyte damage, reflected by CSF PDGFRβ, may be involved in age-related blood-brain barrier disruption together with neuroinflammation, but it is not related to Alzheimer-related pathologic changes. Learn more: https://t.co/fGpOQufbJW #NeuroTwitter https://t.co/0RIQ55YU94
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Mashup Score: 0Global Burden, Risk Factor Analysis, and Prediction Study of Ischemic Stroke, 1990–2030 - 2 year(s) ago
Background and Objectives Ischemic stroke (IS), 1 of the 2 main subtypes of stroke, occurs because of brain ischemia caused by thrombosis of a cerebral blood vessel. IS is one of the most important neurovascular causes of death and disability. It is affected by many risk factors, such as smoking and a high body mass index (BMI), which are also critical in the preventive control of other…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
Global Burden, Risk Factor Analysis, and Prediction Study of Ischemic #Stroke, 1990–2030 https://t.co/CFOmDwImlS #NeuroTwitter https://t.co/6axdgty3FF
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Mashup Score: 4Pearls & Oy‐sters: Paroxysmal Exercise-Induced Dyskinesias Due to Pyruvate Dehydrogenase Deficiency - 2 year(s) ago
Paroxysmal exercise-induced movement disorders may be caused by energy metabolism disorders, such as Glut 1 deficiency, pyruvate dehydrogenase deficiency, or mitochondrial respiratory chain disorders. A 4-year-old boy with a history of febrile seizures presented with paroxysmal dystonia, triggered by exercise, or occurring at rest. Additional investigations demonstrated pallidal hyperintensities…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
Pearls & Oy‐sters: Paroxysmal Exercise-Induced Dyskinesias Due to Pyruvate Dehydrogenase Deficiency https://t.co/qCsyCZIuWY #NeurologyRF #NeuroTwitter https://t.co/9Gye7sG89e
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Via @GreenJournal: A study of 16 @US_FDA-approved drugs for acute or preventive treatment of migraine found that medication trial endpoints were inconsistent within the same indication, mechanistic class, and administration route: https://t.co/kILpy2EVYN #neurotwitter @AANMember https://t.co/gFcM7jQfPM