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Mashup Score: 43Dose-dependent COVID-19 symptoms - Nature Reviews Microbiology - 3 year(s) ago
A monkey challenge study shows that infections with a low virus dose can lead to asymptomatic COVID-19.
Source: Nature Reviews MicrobiologyCategories: Expert Picks, Latest HeadlinesTweet
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Mashup Score: 18Dose-dependent COVID-19 symptoms - Nature Reviews Microbiology - 3 year(s) ago
A monkey challenge study shows that infections with a low virus dose can lead to asymptomatic COVID-19.
Source: Nature Reviews MicrobiologyCategories: Expert Picks, Latest HeadlinesTweet-
In summer of 2020, our group had proposed a hypothesis that SARS-CoV-2 viral dose or "inoculum" was associated with severity of symptoms in COVID (and proposed NPIs reduced the dose). There is now an experimental model showing this in cynomolgus monkeys: https://t.co/dXGDPyPBFZ
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Mashup Score: 2Human papillomaviruses: diversity, infection and host interactions - Nature Reviews Microbiology - 3 year(s) ago
Human papillomaviruses (HPVs) are a diverse group of viruses that replicate in specific anatomical niches of the stratified epithelia. Most HPVs cause asymptomatic infections, some cause benign, proliferative lesions on the skin and mucosa, and others are associated with the development of cancer. In this Review, McBride explores the diversity, evolution, infectious cycle, host interactions and…
Source: Nature Reviews MicrobiologyCategories: Infectious Disease, Latest HeadlinesTweet-
Review in @NatureRevMicro! Alison McBride from @NIAIDNews explores the diversity, evolution, infectious cycle, host interactions and disease association of human #papillomaviruses. https://t.co/DWyQ6vKyoo https://t.co/P5gybGR0LR
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Mashup Score: 20Structural biology of SARS-CoV-2 and implications for therapeutic development - Nature Reviews Microbiology - 3 year(s) ago
Elucidating the structure and function of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins is vital for understanding the molecular mechanisms of viral replication and COVID-19 pathogenesis, and could lead to the development of novel therapeutics. In this Review, Yang and Rao delineate the structural features of SARS-CoV-2 from the whole viral particle to the individual viral…
Source: Nature Reviews MicrobiologyCategories: Infectious Disease, Latest HeadlinesTweet-
RT @NatureRevMicro: Structural biology of SARS-CoV-2 and implications for therapeutic development https://t.co/SgHP84DMSI Rao & Yang deli…
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Mashup Score: 58The microbiota of the respiratory tract: gatekeeper to respiratory health - Nature Reviews Microbiology - 3 year(s) ago
The respiratory tract spans from the nostrils to the lung alveoli and these distinct niches host a diverse microbiota. In this Review, Man, de Steenhuijsen Piters and Bogaert discuss the role of the respiratory microbiota in the maintenance of human health.
Source: Nature Reviews MicrobiologyCategories: Latest Headlines, ManniTweet-
Nice article on how being exposed to a variety of mild pathogens, keeping our respiratory "microbiome" (pathogens colonizing upper respiratory tract) diverse is actually good for respiratory/lung health (though I recognize hard to tolerate colds right now) https://t.co/cevQLXZdQA
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Mashup Score: 0Prisoners of war — host adaptation and its constraints on virus evolution - Nature Reviews Microbiology - 3 year(s) ago
Studies of ancient DNA and endogenous viral elements have revealed extraordinary conservation of virus genome sequences over thousands or millions of years. In this Opinion article, Simmonds, Aiewsakun and Katzourakis describe a niche-filling model that describes how viruses can rapidly evolve to adapt to new host environments while their longer-term evolution is increasingly driven by their…
Source: Nature Reviews MicrobiologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Prisoners of war: host adaptation and its constraints on virus evolution https://t.co/RdsPIV29z6 via @ArisKatzourakis et al
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Mashup Score: 9SARS-CoV-2 variants, spike mutations and immune escape - Nature Reviews Microbiology - 3 year(s) ago
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been characterized by the emergence of mutations and so-called variants of concern that impact virus characteristics, including transmissibility and antigenicity. In this Review, members of the COVID-19 Genomics UK (COG-UK) Consortium and colleagues summarize mutations of the SARS-CoV-2 spike protein, focusing on…
Source: Nature Reviews MicrobiologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Variantes del SARS-CoV-2, mutaciones de la proteína pico y escape inmunológico. Nat Rev Microbiology 2021; DOI: https://t.co/4555PUDiOo https://t.co/1fwKVOXIYh
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Mashup Score: 2SARS-CoV-2 variants, spike mutations and immune escape - 3 year(s) ago
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been characterized by the emergence of mutations and so-called variants of concern that impact virus characteristics, including transmissibility and antigenicity. In this Review, members of the COVID-19 Genomics UK (COG-UK) Consortium and colleagues summarize mutations of the SARS-CoV-2 spike protein, focusing on…
Source: Nature Reviews MicrobiologyCategories: Healthcare Professionals, Latest HeadlinesTweet-
SARS-CoV-2 variants, spike mutations and immune escape | Nature Reviews Microbiology #covid19 https://t.co/y2u0iEN6aL
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Mashup Score: 7SARS-CoV-2 variants, spike mutations and immune escape - 3 year(s) ago
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been characterized by the emergence of mutations and so-called variants of concern that impact virus characteristics, including transmissibility and antigenicity. In this Review, members of the COVID-19 Genomics UK (COG-UK) Consortium and colleagues summarize mutations of the SARS-CoV-2 spike protein, focusing on…
Source: Nature Reviews MicrobiologyCategories: Healthcare Professionals, Latest HeadlinesTweet-
We can also create a mental map about the variants, assuming that certain variants behave similarly because they have functional similarities. But this is getting beyond my pay grade so I'll stop there. https://t.co/mlJ7MQM946
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Mashup Score: 23SARS-CoV-2 variants, spike mutations and immune escape - 3 year(s) ago
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been characterized by the emergence of mutations and so-called variants of concern that impact virus characteristics, including transmissibility and antigenicity. In this Review, members of the COVID-19 Genomics UK (COG-UK) Consortium and colleagues summarize mutations of the SARS-CoV-2 spike protein, focusing on…
Source: Nature Reviews MicrobiologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A Review in @NatureRevMicro summarizes mutations of the SARS-CoV-2 spike protein and discusses them in the context of observed mutation frequencies in global sequence datasets. https://t.co/ljlpelnpTN https://t.co/J3jV2kBpJq
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MODEL SUGGEST INOCULUM HYPOTHESIS: This important paper provides additional data for the inoculum related to severity of infection hypothesis. In cynomolgus monkey model, dose of SARS-CoV-2 given associated with both infection and severity of symptoms. https://t.co/dXGDPyPBFZ