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Mashup Score: 1Long-acting lenacapavir acts as an effective pre-exposure prophylaxis in a rectal SHIV challenge macaque model - 10 month(s) ago
Long-acting lenacapavir acts as an effective pre-exposure prophylaxis in a rectal SHIV challenge macaque model Last Modified: 08:03 AM, Thu Jul 13, 2023 Bekerman E., Yant S.R., VanderVeen L.A., Hansen D., Lu B., Rowe W. The Journal of clinical investigation. 13 July 2023PrEP_alert Study assessed the efficacy of LEN for PrEP in a…
Source: infodisplay.infodesk.comCategories: Latest Headlines, ManniTweet-
LENACAPAVIR: Now have oral pills (TDF/FTC, TAF/FTC) for pre-exposure prophylaxis (PrEP) & long-acting option (cabotegravir, CAB). Next long-acting option (being tested in large PURPOSE studies) could be lenacapavir 1 shot every 6 months! Works in primates https://t.co/Xbnh4LODTS
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Mashup Score: 44Pfizer, Moderna and Novavax gear up for fall Covid vaccine rollout with an important head start - 10 month(s) ago
The FDA’s strain selection puts Pfizer, Moderna and Novavax on track to deliver updated coronavirus shots in time for the fall.
Source: CNBCCategories: Latest Headlines, ManniTweet-
UPDATED VACCINES: Vaccine makers rush to produce XBB1.15 specific boosters for fall but T/B cell immunity (threads below) persist; most countries only targeting boosters for older, those on immunosuppressants; proportion of XBB1.15 subvariant declining now https://t.co/FD4Le8b9fv https://t.co/etPYhwwTuz
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Mashup Score: 14
Do you know some people who almost never get sick and bounce back quickly when they do, while other people frequently suffer from one illness or another? NIAID-supported researchers have pinpointed an attribute of the immune system called immune resilience that helps explain why some people live longer and healthier lives than others.
Source: www.niaid.nih.govCategories: Latest Headlines, ManniTweet-
IMMUNE RESILIENCE: "Based on the relative quantities of two types of white blood cells, CD8+ T cells and CD4+ T cells, which coordinate the immune system’s response to pathogens and kill other cells that have been infected" & genetics (longevity) https://t.co/gkw27ebgHD
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Mashup Score: 606Detecting Selection Bias in Observational Studies—When Interventions Work Too Fast - 11 month(s) ago
This Viewpoint discusses the limitations that observational studies have in drawing causal inferences.
Source: jamanetwork.comCategories: Latest Headlines, ManniTweet-
Our paper in @JAMAInternalMed helps recognize confounding/biases in obs studies. https://t.co/qhptGVAIev Look at image on left-a randomized study in which K better than V (slow separation of curves, plausible). On right-retrospective obs study of VRD vs KRd.Early separation!! https://t.co/mma9vGpueQ
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Just out in @JAMAInternalMed, we highlight a mechanism to detect selection bias/confounding in observational studies by looking at Kaplan Meier curves. If the curves separate implausibly early, the findings are too good to be true! https://t.co/qhptGVAIev @VPrasadMDMPH https://t.co/HAu9CNIIgh
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Mashup Score: 93Updated Covid vaccines need to target XBB omicron variants this fall, FDA staff says - 11 month(s) ago
Vaccine manufacturers Pfizer, Moderna and Novavax will be expected to update their shots according to the strain the FDA selects for the fall.
Source: CNBCCategories: Latest Headlines, ManniTweet-
FDA says fall boosters (Novavax, Moderna, or Pfizer) need to be updated for XBB subvariants. However (next tweet) https://t.co/2NlhBFIZpq
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Mashup Score: 73JAMA IM Early sep curves.pdf - 11 month(s) ago
Page 2 of 2observational study that compared the use of left atrial appendage occlusion and direct oral anticoagulation found that the Kaplan- Meier curves for all-cause mortality separated at day 0 after the de- vices were inserted and the size of the effect increased over time.9,10 However, it is biologically impossible for a stroke prevention device to save lives soon after it is inserted; in…
Source: Google DocsCategories: Latest Headlines, ManniTweet-
Non-paywalled link: https://t.co/5ZSrVZB9OU
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Non-paywalled link to this paper: https://t.co/5ZSrVZB9OU https://t.co/XnwicRcuKx
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Mashup Score: 9Program Overview | UCSF Infectious Diseases - 11 month(s) ago
The University of California, San Francisco offers outstanding fellowship training in Infectious Diseases.
Source: infectiousdiseases.ucsf.eduCategories: Latest Headlines, ManniTweet-
Applying to ID Fellowship? @UCSF_ID offers outstanding clinical training; ranked #5 in ID of universities GLOBALLY (US News). We have strong research mentorship & @UCSF is the No. 1 Public Recipient of NIH funding in 2022. Check out our program here! https://t.co/XGpIL9bjDQ
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Mashup Score: 317Covid-19: UK’s pandemic inquiry prepares to hear from witnesses - 11 month(s) ago
More than three years after the first UK-wide lockdown was ordered in March 2020, and more than a year after Sweden produced its final covid commission report in February 2022, the UK’s covid inquiry is due to hear its first oral evidence, reports Clare Dyer The UK inquiry was set up in June 2022 under Heather Hallett, a retired Court of Appeal judge and crossbench peer.1 It was established…
Source: The BMJCategories: Latest Headlines, ManniTweet-
COVID COMMISSIONS: Most European countries have enacted COVID commissions to see what worked & what didn't; to increase trust in public health. UK launching now; US should; Children should have voice due to school closures; need increased trust, good plan https://t.co/tdUB1UIIls
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Mashup Score: 16Obamacare Mandate for Preventive Care Is Restored, for Now - 11 month(s) ago
Health plans must pay for all types of preventive care, including a pill to prevent H.I.V., while an appeals court deliberates whether to strike down part of the Affordable Care Act.
Source: www.nytimes.comCategories: Latest Headlines, ManniTweet-
PREVENTATIVE CARE: Covered (so important for HIV prevention). "Lawyers reached a deal on Monday to keep the Affordable Care Act’s mandate requiring health plans to cover preventive care at no cost to patients" https://t.co/XE4UsPhYeb
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Mashup Score: 606Detecting Selection Bias in Observational Studies—When Interventions Work Too Fast - 11 month(s) ago
This Viewpoint discusses the limitations that observational studies have in drawing causal inferences.
Source: jamanetwork.comCategories: Latest Headlines, ManniTweet-
Our paper in @JAMAInternalMed helps recognize confounding/biases in obs studies. https://t.co/qhptGVAIev Look at image on left-a randomized study in which K better than V (slow separation of curves, plausible). On right-retrospective obs study of VRD vs KRd.Early separation!! https://t.co/mma9vGpueQ
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Just out in @JAMAInternalMed, we highlight a mechanism to detect selection bias/confounding in observational studies by looking at Kaplan Meier curves. If the curves separate implausibly early, the findings are too good to be true! https://t.co/qhptGVAIev @VPrasadMDMPH https://t.co/HAu9CNIIgh
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LEN)ACAPAVIR: Now have oral pills (TDF/FTC, TAF/FTC) for pre-exposure prophylaxis (PrEP) & long-acting option (cabotegravir, CAB). Next long-acting option (being tested in large PURPOSE studies) could be lenacapavir 1 shot every 6 months! Works in primates https://t.co/Xbnh4LODTS