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Mashup Score: 9Serine catabolism generates liver NADPH and supports hepatic lipogenesis - Nature Metabolism - 3 year(s) ago
Liver and adipose tissue are shown to use different metabolic routes to generate NADPH for de novo lipogenesis, with the liver relying on a unique cytosolic serine catabolic pathway involving the enzyme SHMT1.
Source: Nature MetabolismCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 3Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice - Nature Metabolism - 3 year(s) ago
Pak et al. show that prolonged fasting is required for the effects of calorie restriction on insulin sensitivity, fuel utilization and ageing in mice.
Source: Nature MetabolismCategories: Latest Headlines, Oncologists1Tweet-
Dangit. Another study showing that fasting increases life span and metabolic health. My frequent snacks are going to kill me. https://t.co/w6iHx0I1Rf
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Mashup Score: 68Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication - Nature Metabolism - 3 year(s) ago
Pharmacological inhibitors of fatty acid synthase, including the approved anti-obesity drug orlistat, are shown to inhibit replication of SARS-CoV-2 in vitro and in a mouse model of infection in vivo.
Source: Nature MetabolismCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Pharmacological inhibitors of fatty acid synthase, including the approved anti-obesity drug orlistat, are shown to inhibit replication of SARS-CoV-2 in vitro and in a mouse model of infection in vivo, according to a paper in @NatMetabolism. https://t.co/JaAEoAifpx https://t.co/Iwah8QgFS3
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Mashup Score: 38Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication - Nature Metabolism - 3 year(s) ago
Pharmacological inhibitors of fatty acid synthase, including the approved anti-obesity drug orlistat, are shown to inhibit replication of SARS-CoV-2 in vitro and in a mouse model of infection in vivo.
Source: Nature MetabolismCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Pharmacological inhibitors of fatty acid synthase, including the approved anti-obesity drug orlistat, are shown to inhibit replication of SARS-CoV-2 in vitro and in a mouse model of infection in vivo, according to a paper in @NatMetabolism. https://t.co/B3HRLRergs https://t.co/dlyw05GMRG
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Mashup Score: 11Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075 - Nature Metabolism - 3 year(s) ago
Ji and Luo et al. show that miR-3075 in hepatocyte-derived exosomes from mice at early stages of obesity improves insulin sensitivity in chronically obese mice, while hepatocyte exosomes from chronically obese mice induce insulin resistance.
Source: Nature MetabolismCategories: Endocrinology, Latest HeadlinesTweet-
Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075 https://t.co/a1ZvZYhvJJ via @NatMetabolism
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Mashup Score: 33Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity - Nature Metabolism - 3 year(s) ago
Hild et al. find that a wild-derived microbiome protects against weight gain through early postnatal metabolic programming and brown adipose tissue activation.
Source: Nature MetabolismCategories: Healthcare Professionals, Latest HeadlinesTweet-
RT @jfcryan: Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity https://t.co/8FpAO9xt6I
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Mashup Score: 3
Wigger, Barovic and Brunner et al. perform a multidimensional analysis of islets from metabolically characterized patients who had undergone pancreatectomy, observing remarkable heterogeneity between samples from individuals with type 2 diabetes, thus arguing against models of linear beta-cell dedifferentiation in diabetes.
Source: Nature MetabolismCategories: Endocrinology, Latest HeadlinesTweet-
@msanderlab And the original paper from @NatMetabolism is here -> https://t.co/UhFAcSjnoY
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Mashup Score: 7Mitochondrial pyruvate carriers are required for myocardial stress adaptation - Nature Metabolism - 4 year(s) ago
Metabolic substrate partitioning underlies myocardial homeostatic capacity and adaptation to stress. Zhang et al. show that decreasing mitochondrial pyruvate carrier expression redirects glycolytic intermediates and leads to heart failure, which is prevented or reversed with a high-fat or ketogenic diet.
Source: Nature MetabolismCategories: Endocrinology, Latest HeadlinesTweet-
@IowaMed @IntMedatIowa @uihealthcare @DaretoDiscover @AHA_Research @AHAScience @Mitoverse @IowaPSTP Congratulations @Ruloyy (Yuan) on receiving an @AHAScience @AHA_Research Career Development Award to follow up your beautiful work on novel metabolic regulators of heart failure! Thanks @Mitoverse for your spport. https://t.co/Qs3pP0MF5d
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Mashup Score: 15
Diabetes therapeutic approaches continue to expand and to be refined. As the field moves toward more intensive insulin- and cell-based therapies, care must be taken to mimic healthy physiological insulin dynamics and avoid hyperinsulinemia, with its deleterious downstream complications.
Source: Nature MetabolismCategories: Hem/Oncs, Latest HeadlinesTweet-
Avances en la sustitución de células beta del páncreas con células madre para el tratamiento de la Diabetes. Grandes avances pero también retos importantes como los costos, verdadera eficacia y retos en su fabricación. Por Nature: https://t.co/MRT5a2V9jI https://t.co/KTkbDol9Rx
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Mashup Score: 2Journal milestones - 4 year(s) ago
Since the publication of its first issue in January 2019, Nature Metabolism has come a long way. Here, we reflect on watching our journal develop and grow, highlighting some of the important milestones on our journey.
Source: Nature MetabolismCategories: Endocrinology, Latest HeadlinesTweet-
RT @NatMetabolism: Online now! Journal milestones https://t.co/CTQ4Bl4nHb
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RT @NatMetabolism: Online now! Serine catabolism generates liver NADPH and supports hepatic lipogenesis https://t.co/A6bpnQzFVF https://t.c…