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Mashup Score: 12
Haas, Velten and colleagues use single-cell multiomics of human blood and bone marrow to generate a reference map allowing the quantitative linking of cytometry and proteo-genomic information.
Source: Nature ImmunologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 28
Peng et al. find that immunodominant cytotoxic T lymphocytes (CTLs) specific for NP105–113-B*07:02 are associated with reduced COVID-19 severity. Mechanistically, NP105–113-B*07:02-specific CTLs show potent antiviral functionality and may represent rational T cell vaccine targets.
Source: Nature ImmunologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A study in @NatImmunol identifies a specific CD8+ T cell associated with reduced COVID-19 severity. It shows potent antiviral functionality and may represent rational T cell vaccine targets, according to the paper. https://t.co/XbLxpYvG2c https://t.co/hbhoPjwRQV
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Mashup Score: 0Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses - Nature Immunology - 2 year(s) ago
Mutations in the RNA-binding proteins Roquin-1 or Regnase-1 cause systemic autoimmunity. Heissmeyer and colleagues show that Roquin-1 and Regnase-1 physically interact and thereby regulate CD4+ and CD8+ T cell metabolism and functionality.
Source: Nature ImmunologyCategories: Latest Headlines, Oncologists2Tweet-
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses | Nature Immunology https://t.co/iKxqWjRoSi
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Mashup Score: 1
Haas, Velten and colleagues use single-cell multiomics of human blood and bone marrow to generate a reference map allowing the quantitative linking of cytometry and proteo-genomic information.
Source: Nature ImmunologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A study in @NatImmunol uses single-cell multiomics of human blood and bone marrow to generate a reference map allowing the quantitative linking of cytometry and proteo-genomic information. https://t.co/iR6IiOcDln https://t.co/lazHjsVId8
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Mashup Score: 3High-throughput and high-dimensional single-cell analysis of antigen-specific CD8+ T cells - Nature Immunology - 2 year(s) ago
Jiang and colleagues describe a high-dimensional, high-throughput tetramer-associated TCR sequencing (TetTCR-SeqHD) method to simultaneously profile TCR sequences, cognate antigen specificities, targeted gene expression and surface-protein expression from tens of thousands of single cells.
Source: Nature ImmunologyCategories: Future of Medicine, Latest HeadlinesTweet-
TetTCR-SeqHD, a tetramer-based method for TCR sequencing, enables profiling of antigen specificities, targeted gene expression and surface-protein expression at the single cell level and at high throughput. #NBThighlight https://t.co/TKo8u0XWMq
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Mashup Score: 31
The extreme diversity of the human immune system, forged and maintained throughout evolutionary history, provides a potent defense against opportunistic pathogens. Liston and colleagues review the current state of play in the field, identify the key unknowns in the causality of immune variation and identify the multidisciplinary pathways toward an improved understanding.
Source: Nature ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
Liston et al review the diversity of the human immune system, which provides a potent defense against opportunistic pathogens. They discuss the key drivers and pathways in the causality of immune variation. https://t.co/gruRxJrPl6 https://t.co/TTAcA4VI2p
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Mashup Score: 38Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells - Nature Immunology - 3 year(s) ago
During homeostasis TH1 cells activate a cell-intrinsic inflammatory shutdown program and shift to IL-10 production. Chauss et al. find that this TH1 homeostatic program is dependent on vitamin D signaling and is disrupted in severe COVID-19.
Source: Nature ImmunologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
During homeostasis TH1 cells activate a cell-intrinsic inflammatory shutdown program and shift to IL-10 production. A study in @NatImmunol find that this TH1 homeostatic program is dependent on vitamin D signaling and is disrupted in severe COVID-19. https://t.co/xCOnvK7ilN https://t.co/zebfLPTOVq
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Mashup Score: 28A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection - Nature Immunology - 3 year(s) ago
In this Perspective, Spaan and colleagues propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.
Source: Nature ImmunologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A Perspective in @NatImmunol proposes a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection. https://t.co/RgSH1xjdqz https://t.co/9bRXryq25N
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Mashup Score: 34Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations - Nature Immunology - 3 year(s) ago
Krebs and colleagues identify multiple mAbs that recognize either the RBD or the NTD of SARS-CoV-2 spike protein that have potent cross-neutralizing activities against variants of concern. Combinatorial mAb cocktails have complementary effects on viral neutralization and Fc effector functions and can protect against SARS-CoV-2 escape mutants.
Source: Nature ImmunologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A study in @NatImmunol identifies multiple monoclonal antibodies that recognize either the RBD or the NTD of SARS-CoV-2 spike protein that have potent cross-neutralizing activities against variants of concern. https://t.co/aOvgT05ZRw https://t.co/Lw11sdgGEf
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Mashup Score: 7Nature Immunology - 3 year(s) ago
Nature Immunology, ranked first out of more than 100 primary immunology research journals, brings together the most significant immunology research from every …
Source: Nature ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
See the discussion arising from a recent NIAID virtual workshop on the topic of secondary vaccine effects, potential immunological mechanisms and associated public health implications. Online now in the Nov issue (https://t.co/B6wez0mFvd) https://t.co/1th0ANFBBT
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A study in @NatImmunol uses single-cell multiomics of human blood and bone marrow to generate a reference map allowing the quantitative linking of cytometry and proteo-genomic information. https://t.co/UgkTKm1BDn https://t.co/yjn5aVGqKa