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Mashup Score: 3
Scheiermann and colleagues show that circadian clocks control the infiltration of dendritic cells into skin lymphatics in mice and humans, with a peak migration to the lymph nodes during the rest phase.
Source: Nature ImmunologyCategories: Hematologists1, Latest HeadlinesTweet
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Mashup Score: 4The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate - Nature Immunology - 3 year(s) ago
Many babies have now been born to mothers who were exposed to SARS-CoV-2 during their pregnancy. Here the authors look at the effect of this exposure on the immunology of human neonates, showing immune changes and increased neonatal cytokine responses despite limited evidence of vertical transmission.
Source: Nature ImmunologyCategories: Infectious Disease, Latest HeadlinesTweet-
Published in @NatImmunol: Scientists characterized the immunology of neonates born to mothers with confirmed #SARS-CoV-2 infection during #pregnancy. They showed that maternal SARS-CoV-2 infection affected the neonatal #ImmuneSystem. https://t.co/tP3BEhOe7M https://t.co/bk3GH0Iy4u
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Mashup Score: 2Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation - Nature Immunology - 3 year(s) ago
Adipose tissue macrophages are intimately involved with adipocytes to orchestrate whole-body energy metabolism. Qiu and colleagues show that myeloid-specific deletion of the homeobox protein IRX3 protects against diet-induced obesity, excessive proinflammatory cytokine secretion and metabolic diseases via increasing adaptive thermogenesis.
Source: Nature ImmunologyCategories: Healthcare Professionals, Latest HeadlinesTweet-
RT @Derpology: "Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation | Nature Immunology" https://t.co/Cxnd5PBKSh
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Mashup Score: 1
Understanding the mechanistic basis of vaccine efficacy is crucial to the development of next-generation vaccines. Sekaly and colleagues find that activation of the transcription factor CREB1 by the RV144 HIV-1 vaccine underpins the induction of robust adaptive immunity.
Source: Nature ImmunologyCategories: Infectious Disease, Latest HeadlinesTweet-
Published in @NatImmunol: This integrated systems biology approach has validated #CREB1 as a critical driver of #vaccine efficacy and highlights that adjuvants that trigger CREB1 signaling may be critical for efficacious #HIV-1 vaccines. 💉 https://t.co/p6UeM4pvC7 https://t.co/0SLZxg3aVc
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Mashup Score: 1An updated guide for the perplexed: cytometry in the high-dimensional era - Nature Immunology - 3 year(s) ago
High-dimensional cytometry experiments measuring 20–50 cellular markers have become routine in many laboratories. The increased complexity of these datasets requires added rigor during the experimental planning and the subsequent manual and computational data analysis to avoid artefacts and misinterpretation of results. Here we discuss pitfalls frequently encountered during high-dimensional…
Source: Nature ImmunologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In an article published in @NatImmunol, Florian Mair of the @PrlicLab at Fred Hutch and collaborators provide updated guidelines for generating and analyzing high parameter #cytometry data. https://t.co/05tiawNaco https://t.co/Glli2BYEig
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Mashup Score: 4An updated guide for the perplexed: cytometry in the high-dimensional era - Nature Immunology - 3 year(s) ago
High-dimensional cytometry experiments measuring 20–50 cellular markers have become routine in many laboratories. The increased complexity of these datasets requires added rigor during the experimental planning and the subsequent manual and computational data analysis to avoid artefacts and misinterpretation of results. Here we discuss pitfalls frequently encountered during high-dimensional…
Source: Nature ImmunologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In an article published in @NatImmunol, Florian Mair of the @PrlicLab at Fred Hutch and collaborators provide updated guidelines for generating and analyzing high parameter #cytometry data. https://t.co/05tiax4L3W https://t.co/oeeqSOIubQ
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Mashup Score: 6An updated guide for the perplexed: cytometry in the high-dimensional era - Nature Immunology - 3 year(s) ago
High-dimensional cytometry experiments measuring 20–50 cellular markers have become routine in many laboratories. The increased complexity of these datasets requires added rigor during the experimental planning and the subsequent manual and computational data analysis to avoid artefacts and misinterpretation of results. Here we discuss pitfalls frequently encountered during high-dimensional…
Source: Nature ImmunologyCategories: Hem/Oncs, Latest HeadlinesTweet-
An updated guide for the perplexed: cytometry in the high-dimensional era | Nature Immunology https://t.co/znMHLhFdXr
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Mashup Score: 1TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer - Nature Immunology - 3 year(s) ago
Khazaie and colleagues show that TCF-1 cooperates with FOXP3 to differentially regulate independent suppressive activities of Treg cells. Treg cell–specific deficiency of TCF-1 increases tumor load in mice predisposed to polyposis. Functionally, TCF-1-deficient Treg cells suppress viral antigen–specific CD8+ T cell cytotoxicity, but TCF-1-deficient Treg cells fail to suppress TH1 or TH17…
Source: Nature ImmunologyCategories: Latest Headlines, Oncologists2Tweet-
TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer | Nature Immunology https://t.co/ZLKlK9Iirb
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Mashup Score: 45The dual-function CD150 receptor subfamily: the viral attraction - Nature Immunology - 3 year(s) ago
The CD150 subfamily within the CD2 family is a growing group of dual-function receptors that have within their cytoplasmic tails a characteristic signaling motif. The ITSM (immunoreceptor tyrosine-based switch motif) enables these receptors to bind to and be regulated by small SH2 domain adaptor proteins, including SH2D1A (SH2-containing adaptor protein SH2 domain protein 1A) and EAT-2…
Source: Nature ImmunologyCategories: Infectious Disease, Latest HeadlinesTweet-
We hypothesized then that measles was destroying B cells and plasma cells responsible for retaining immune memory. This is bc the measles virus specifically attacks immune memory cells via attachment to CD150 - a protein enriched on memory cells. 3/ https://t.co/tK6Zw0MAqs 3/
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Mashup Score: 36mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates - Nature Immunology - 3 year(s) ago
The beta variant (B.1.351) is to date the most resistant to neutralization of the SARS-CoV-2 variants. Using nonhuman primates, Seder and colleagues demonstrate that double vaccination with a high dose of the lipid nanoparticle vaccine mRNA-1273 protects against infection with the beta variant.
Source: Nature ImmunologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Double vaccination with a high dose of Moderna's COVID-19 vaccine protects against Beta variant infection in nonhuman primates, reports a study in @NatImmunol. Higher neutralizing responses against Delta were also observed after two doses compared to one. https://t.co/D9gd2YgywZ https://t.co/d8YkzEdUYu
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Fascinating new publication in @NatImmunol re: our immune system's circadian ⏰ Raise your hand if you think autologous or allogeneic #BMT might disrupt this phenomenon? 👋🏽 Would be interesting to find out! https://t.co/FQzwcNVcpk