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Mashup Score: 0Comparative Proteomic Analysis Identifies Key Metabolic Regulators of Gemcitabine Resistance in Pancreatic Cancer - 1 year(s) ago
In BriefFor pancreatic cancer (PDAC) patients, gemcitabine resistance (GemR) represents a major clinical problem. Global quantitative differential proteomic analysis of highly GemR PDAC cells developed from relatively Gem-sensitive PDAC cell lines identified multiple networks within the thousands of quantified proteins that support adaptation to Gem-induced stress, and reveal the complexity of…
Source: Molecular & Cellular ProteomicsCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Phosphoproteome Analysis Identifies a Synaptotagmin-1-Associated Complex Involved in Ischemic Neuron Injury - 2 year(s) ago
In BriefTo investigate the role of protein modification in the hippocampus after cerebral ischemia onset, we used a quantitative proteomics approach to study proteome and phosphoproteome profiles of the acute cerebral ischemic hippocampus in middle cerebral artery occlusion mouse model. Bioinformatic analysis revealed that phosphoproteins fall into a variety of biological processes of synaptic…
Source: Molecular & Cellular ProteomicsCategories: Latest Headlines, NeurologyTweet-
Jiang et al.'s results reveal a mechanism underlying neuronal injury and may provide new targets for neuroprotection after acute cerebral ischemia onset ― Hunan University #neuro #ischemia #TeamMassSpec #hippocampus https://t.co/5NKeEiYMb4
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Mashup Score: 1Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression - 2 year(s) ago
In BriefThe tumor microenvironment (TME) features immunosuppressive regulatory T cells (Tregs) and areas of hypoxia. Given the importance of surface proteins in T cell antitumor function, we performed quantitative cell surface proteomics to determine how these factors affect the primary effector T cell surface proteome (surfaceome). We discovered that Treg coculture and hypoxia reduced expression…
Source: Molecular & Cellular ProteomicsCategories: Allergy-Immunology, Latest HeadlinesTweet-
Why is immune response in tumors so weak? Recently in @MolCellProt, researchers in @realJimWells lab studied tumor microenvironment effects on T cell surfaceome, reporting that hypoxia > Tregs. Read more: https://t.co/5cim5medqW
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Mashup Score: 0Comparative Analysis of T Cell Spatial Proteomics and the Influence of HIV Expression - 2 year(s) ago
As systems biology approaches to virology have become more tractable, highly studied viruses such as HIV can now be analyzed in new, unbiased ways, including spatial proteomics. We employed here a differential centrifugation protocol to fractionate Jurkat T cells for proteomic analysis by mass spectrometry; these cells contain inducible HIV-1 genomes, enabling us to look for changes in the…
Source: Molecular & Cellular ProteomicsCategories: Allergy-Immunology, Latest HeadlinesTweet-
Oom et al. findings illustrate important considerations for studies of the spatial proteome following viral infection or viral gene expression and provide a reference for future studies of HIV-gene-dropout viruses — @UCSDMedSchool @UCSDBMS #HIV1 https://t.co/fiidD3kNOA
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Mashup Score: 0Multidimensional Dynamics of the Proteome in the Neurodegenerative and Aging Mammalian Brain - 2 year(s) ago
In BriefNeurodegenerative diseases are characterized by the abnormal accumulation of aggregated proteins in the brain. Using in vivo pulse isotope labeling, we screened the proteome for changes in protein turnover and abundance in multiple mouse models of neurodegeneration. These data suggest that the disease state of pathologically affected tissue is characterized by a proteome-wide increase in…
Source: Molecular & Cellular ProteomicsCategories: Latest Headlines, NeurologyTweet-
Andrews et al.'s simple multidimensional approach enables the comprehensive mapping of proteome dynamics and identifies affected proteins in mouse models of disease and other live animal test settings — @MRC_LMB @UniversityLeeds @drrenefrank #neuro https://t.co/BIORq12tdT
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Mashup Score: 0Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease - 2 year(s) ago
Quantitative proteomics revealed differentially expressed proteins in paired colon tissues from 21 patients diagnosed with Hirschsprung disease (HSCR). Hierarchical clustering suggests that the protein abundancy and expression pattern in normal intestinal tissues are closely related to gender. Gene ontology enrichment analysis revealed spliceosome, axon guidance, and extracellular exosome as the…
Source: Molecular & Cellular ProteomicsCategories: Latest Headlines, NeurologyTweet-
Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With #Hirschsprung Disease These findings will shed new light on the pathogenesis of HSCR and facilitate the development of therapeutic targets. https://t.co/23pnInzmYl
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Mashup Score: 0Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis - 2 year(s) ago
In BriefThe article contains the first whole brain proteomic survey from a mouse model of Alexander disease (AxD). Several novel findings include activation of the PPAR signaling pathway, which has been reported to be protective in models of amyotrophic lateral sclerosis (ALS). Another finding related to the gliosis phenotype in AxD mice was the upregulation of fatty acid binding protein 7…
Source: Molecular & Cellular ProteomicsCategories: Latest Headlines, NeurologyTweet-
Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of #AlexanderDisease with Severe Reactive Gliosis @VTNeuro @ucdavis @UCDProteomics #neuro #AxD https://t.co/F1yo6TjKHA
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Mashup Score: 1Proteogenomic Analysis Unveils the HLA Class I-Presented Immunopeptidome in Melanoma and EGFR-Mutant Lung Adenocarcinoma - 2 year(s) ago
In BriefCancer immunotherapy is ineffective in low TMB EGFR-mutant lung adenocarcinoma. Qi et al. performed a comprehensive proteogenomic profiling of HLA class I-presented immunopeptides in high TMB melanoma and low TMB EGFR-mutant lung cancer. Similar numbers of immunopeptides were identified from both. Variant, CG antigen, PTM, and lncRNA-derived peptides were identified. A novel strategy to…
Source: Molecular & Cellular ProteomicsCategories: Allergy-Immunology, Latest HeadlinesTweet-
Qi et al. provide direct evidence of HLA Class I presentation of a large number of variant and tumor-associated peptides in both low and high TMB cancer ― @NIH #immunotherapy #lungcancer https://t.co/PrNh5Ixt4y
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Mashup Score: 0MSstatsTMT: Statistical Detection of Differentially Abundant Proteins in Experiments with Isobaric Labeling and Multiple Mixtures - 2 year(s) ago
MSstatsTMT implements a general statistical approach for relative protein quantification and tests for differential abundance in mass spectrometry-based experiments with TMT labeling. It is applicable to experiments with multiple conditions, multiple biological replicate runs and multiple technical replicate runs, and unbalanced designs. Evaluation on a controlled mixture, simulated datasets, and…
Source: Molecular & Cellular ProteomicsCategories: Genetics, Latest HeadlinesTweet-
MSstatsTMT: Statistical Detection of Differentially Abundant Proteins in Experiments with Isobaric Labeling and Multiple Mixtures https://t.co/6sY6tlo16k @molcellprot https://t.co/Ydr8zeHFoy
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Mashup Score: 0A Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients * - 2 year(s) ago
Orbitrap Exploris 480 MS with FAIMS Pro provides fast, sensitive and robust profiling of proteomes when combined with Evosep One. The combination of Data Independent Acquisition (DIA) and FAIMS with single compensation voltages enables analysis of up to 2000 peptides per LC gradient minute and more than 5000 protein groups in twenty minutes. DIA-FAIMS based label-free quantitation achieves…
Source: Molecular & Cellular ProteomicsCategories: Genetics, Latest HeadlinesTweet-
A Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients https://t.co/KjMcGTo813 @molcellprot https://t.co/83Z7yU2VHD
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Comparative Proteomic Analysis Identifies Key Metabolic Regulators of Gemcitabine Resistance in Pancreatic Cancer - Molecular & Cellular Proteomics https://t.co/GwpDwFeqhz